Thyroid dysfunction in chronic myeloid leukemia patients on nilotinib

Khaleel, Khaleed J; Matloob, Ahmed H; Hatim, Abdalsalam

doi:10.4103/ijh.ijh_39_17

Cited by 2 publications

(2 citation statements)

References 2 publications

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“…The International Randomized Study of Interferon and STI571 (IRIS) is considered a landmark clinical trial for CML treatment with TKIs. Imatinib selectively inhibits BCR-ABL competitively, as well as several other kinases, including stem cell factor receptor (KIT), platelet-derived growth factor receptor (PDGFR), and colony-stimulating factor receptor-1 (CSF-1R) [ 8 ]. Other TKIs, such as dasatinib, nilotinib, bosutinib have also been used in CML patients.…”

Section: Introductionmentioning

confidence: 99%

Tyrosine kinase inhibitors induced thyroid dysfunction: myth or reality?

Malhotra,

Gupta,

Mahajan

2023

Rep Pract Oncol Radiother.

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Background Chronic myelogenous leukemia (CML) is a hematopoietic stem cell disorder. It is associated with acquired genetic changes in the hematopoietic stem cells in the form of BCR-ABL fusion gene also known as Philadelphia chromosome. Materials and methods We prospectively studied thyroid function at baseline and at 6 months of imatinib treatment in 26 newly diagnosed BCR-ABL positive CML patients. Result The thyroid-stimulating hormone (TSH) levels increased significantly from baseline (3.20 ± 0.978 mIU/L vs . 3.724 ± 1.726 mIU/L, p < 0.05) after 6 months of treatment, 88.4% of the patients remained euthyroid. Only 2 patients had subclinical hypothyroidism, 1 had hypothyroidism after 6 months of tyrosine kinase inhibitors (TKI) therapy. Conclusion Imatinib did not have any significant effect on thyroid function in CML patients in this study.

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Section: Introductionmentioning

confidence: 99%

Tyrosine kinase inhibitors induced thyroid dysfunction: myth or reality?

Malhotra,

Gupta,

Mahajan

2023

Rep Pract Oncol Radiother.

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“…The impact of bacteria IAA‐producer on plants appeared varied from pathogenesis to phyto‐stimulation [3] . The coordination feature of HIAA hormone led to its use for preparing Co(II), Ni(II), Cu(II) and Pt(IV) complexes [4] . Such complexes were characterized and elucidated by analytical and spectral aspects.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Al(III), Bi(III), Sb(III), Sn(II) and Pb(II) Complexes Based on a Plant Auxin Hormone: Characterization; DFT, Pharmacokinetics and MOE‐Docking with Plant‐Cell Proteins

et al. 2021

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Series of complexes was prepared from some p‐block elements and indole‐3‐acetic acid (HIAA) as a plant hormone categorized from auxin class. Trivalent [Al(III), Bi(III)& Sb(III)] and divalent [Sn(II) & Pb(II)] ions, were used for complexation with indole‐3‐acetic acid. These complexes were analytically (elemental & EDX), spectrally (IR, Raman, UV‐Vis, SEM & XRD) and theoretically characterized. All complexes proposed having 1 : 2 molar ratio (M : L) through mono‐negative bi‐dentate binding mode. A tetrahedral geometry was proposed for Al(III) complex. While, the other complexes were suggested to be in distorted octahedral geometry due to presence of five bonds only and the sixth site inhabits by lone pair of electrons. Hirshfeld surface properties were obtained through Crystal explorer 3.1 software over structures oriented by VESTA package. The 3D‐crystals of Bi(III) and Sb(III) complexes displayed a noticeable red spots which point to the best contact site on their surfaces. Also, the conformational study reveals many physical characteristics that suggest the superiority of some complexes than the original ligand. Also, drug‐likeness outcomes clarify the lipophilic feature of Sn(II) and Pb(II) complexes. This feature may play a well bioactive behavior within living cells. Furthermore, pharmacokinetics as well as MOE‐docking simulation, were carried out versus 1lr5 & 3c6p proteins. Such proteins, were the co‐crystal forms of auxin‐class that act as hormone receiver inside plant cells. This study proposed the priority of Al(III), Sn(II) and Pb(II) complexes than the free hormone itself in the interaction with selected auxin proteins. We recommend these complexes for practical application in the field from specialist, they will improve the vital process within plant cells based on in‐silico results in this research.

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Thyroid dysfunction in chronic myeloid leukemia patients on nilotinib

Cited by 2 publications

References 2 publications

Tyrosine kinase inhibitors induced thyroid dysfunction: myth or reality?

Tyrosine kinase inhibitors induced thyroid dysfunction: myth or reality?

Synthesis of Al(III), Bi(III), Sb(III), Sn(II) and Pb(II) Complexes Based on a Plant Auxin Hormone: Characterization; DFT, Pharmacokinetics and MOE‐Docking with Plant‐Cell Proteins

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