Thyroid dysfunction in Down's syndrome: relation to age and thyroid autoimmunity

Posner, Ewa; Colver, Allan

doi:10.1136/adc.81.3.278o

Cited by 5 publications

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“…Considering the total universe of patients with DS, the frequency of autoimmune thyroid disease is described to be between 20% and 66%, depending on the type of study, sample size, region, age group and the inclusion of hypo-or hyperthyroidism cases (13)(14). It is possible that previous studies also included DS patients with TSH-nd, without TH and without hypothyroidism, producing a large number of false positive results.…”

Section: Discussionmentioning

confidence: 99%

TSH neurosecretory dysfunction (TSH-nd) in Down syndrome (DS): low risk of progression to Hashimoto's thyroiditis

Faria

Ribeiro

Kochi

et al. 2011

Arq Bras Endocrinol Metab

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INTRODUCTION: Patients with Down syndrome (DS) often have elevated TSH (hypothalamic origin), which is called TSH neurosecretory dysfunction (TSH-nd). In these cases, there is slight elevation in TSH (5-15 µUI/mL), with normal free T4 and negative thyroid antibodies (AB). OBJECTIVE: To recognize the risk of progression to Hashimoto's thyroiditis (HT). SUBJECTS AND METHODS: We retrospectively analyzed 40 DS patients (mean age = 4.5 years), followed up for 6.8 years. RESULTS: HT was diagnosed in 9/40 patients, three early in monitoring, and six during evolution. In 31/40 patients, TSH-nd diagnosis remained unchanged over the years, with maximum TSH values ranging from 5 to 15 µUI/mL. In this group, free T4 also remained normal and AB were negative. There was a significant TSH reduction (p = 0.017), and normal TSH concentrations (< 5.0 µUI/mL) were observed in 29/31 patients, in at least one moment. No patient had TSH > 15 µUI/mL. CONCLUSION: DS patients with TSH-nd present low risk of progression to HT (10% for females and 6% for males).

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Section: Discussionmentioning

confidence: 99%

TSH neurosecretory dysfunction (TSH-nd) in Down syndrome (DS): low risk of progression to Hashimoto's thyroiditis

Faria

Ribeiro

Kochi

et al. 2011

Arq Bras Endocrinol Metab

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“…(Cronk C, 1988). (Aumonier ME, 1983, McBride MC, 1987 (Saenz R, 1999 (Cronk C, 1988), ÛÙË ¢•Ó›• (Cremers MJ, 1996), ÛÙË ™Ô˘Ë‰›• (Myrelid A, 2002) Î•È ÛÙËÓ Ι•ˆÓ›• (Kimura J, 2003 (Cronk C, 1988 (Fort P, 1984 (Fort P 1984, Cutler AT 1985, Pozzan GB 1990 (Fort P 1984, Cutler AT 1985 (Cutler AT 1985, Jaruratanasirikul S 1998 (Peuschel SM 1985, Zori RT 1990, Karlsson B 1998 (Loudon MM 1985, Zori RT 1990, Kennedy RL 1992, Toledo 1997, Postner EB 1999 (Cutler AT, 1985, Loudon, MM 1985, Pozzan GB, 1990, Rubello D, 1995 (Sharav T 1988, Sharav T 1991 (Peuschel SM 1985, Pozzan GB 1990 Dias J, 1990, Storm W, 1990, Zubilaga P, 1993, George EK, 1995, Gale L, 1997, Carlsson A, 1998, Zachor DA, 2000, Fasano A, 2003. ∞Ó Û˘ÌÂÚÈÏËÊıÔ ‡Ó Î•È ÂÓ‹ÏÈÎÂ˜ ÌÂ DS Êı¿ÓÂÈ Ì¤¯ÚÈ 13,7% (Bentley MB, 1975 ...…”

Section: ∞èì•ùôïôáèî¤˜ ‰è•ù•ú•¯¤∏mentioning

confidence: 99%

Συμβολή στην πρωτοβάθμια φροντίδα παιδιών και εφήβων με σύνδρομο down

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Thyroid dysfunction in children with Down's syndrome

Tüysüz

Beker

2001

Acta Paediatrica

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The prevalence of congenital hypothyroidism was 1.8% in children with Down's syndrome while 25.3% of them had compensated hypothyroidism. It is suggested that Down's syndrome patients with normal thyroid functions and those with compensated hypothyroidism should be followed annually and every 3 mo, respectively. Besides congenital hypothyroidism cases, those with TSH levels between 11 and 20 mU l(-1) may benefit from treatment with low-dose thyroxine.

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Thyroid dysfunction in Down's syndrome: relation to age and thyroid autoimmunity

Cited by 5 publications

References 1 publication

TSH neurosecretory dysfunction (TSH-nd) in Down syndrome (DS): low risk of progression to Hashimoto's thyroiditis

TSH neurosecretory dysfunction (TSH-nd) in Down syndrome (DS): low risk of progression to Hashimoto's thyroiditis

Συμβολή στην πρωτοβάθμια φροντίδα παιδιών και εφήβων με σύνδρομο down

Thyroid dysfunction in children with Down's syndrome

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