Thyroid Fine-Needle Aspiration Cytology: Focusing on Adherence to Guidelines and Hospital Organization

Ammendola, Serena; Girolami, Ilaria; Bovo, Chiara; Paini, Marina; Castelli, Claudia; Bruno, Costanza; Schenal, Giacomo; Brazzarola, Paolo; Mezzetto, Luca; Veraldi, Gian Franco; Novelli, Luca; Brunelli, Matteo; Montemezzi, Stefania; Eccher, Albino

doi:10.12659/ajcr.920933

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…Newly discovered NTs in potential organ donors need to be investigated to rule out cancer and avert any subsequent risk of transmission. 40 However, there are no established protocols that clearly address the management of thyroid nodules in deceased donors for transplantation. 41 Our findings have some significance in the context of the donor population.…”

Section: Discussionmentioning

confidence: 99%

Detection of Thyroid Nodule Prevalence and Associated Risk Factors in Southwest China: A Study of 45,023 Individuals Undergoing Physical Examinations

Liu¹,

Li²,

Wang³

et al. 2023

DMSO

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Background Thyroid nodules (TNs) are among the most common thyroid lesions, and rates of these nodules have risen over the past three decades. As the majority of TN patients remain asymptomatic when these nodules are in the early stages of development, malignant nodules may continue to develop into thyroid cancer when not detected. As such, early screening and diagnosis-based strategies represent the most promising means of preventing or treating TNs and associated cancers. The present study was thus developed to explore TN prevalence among individuals in Luzhou, China. Methods Here, thyroid ultrasonography and metabolic-related indicators from 45,023 adults undergoing routine physical examinations in the Health Management Center of a large Grade A hospital in Luzhou over the last three years were retrospectively reviewed in an effort to identify factors associated with TN risk and the detection of these nodules through univariate and multivariate logistic regression analyses. Results In total, 13,437 TNs were detected in these 45,023 healthy adults for an overall 29.8% detection rate. This TN detection rate rose with age, and multivariate logistic regression analyses revealed that independent risk factors associated with TNs included greater age (≥31 years old), female (OR = 2.283, 95% CI: 2.177–2.393), central obesity (OR = 1.115, 95% CI: 1.051–1.183), impaired fasting glucose (OR = 1.203, 95% CI: 1.063–1.360), overweight status (OR = 1.085, 95% CI: 1.026–1.147), and obesity (OR = 1.156, 95% CI: 1.054–1.268), while low BMI was a protective factor associated with lower rates of TN incidence (OR = 0.789, 95% CI: 0.706–0.882). When results were stratified by gender, impaired fasting glucose was not an independent predictor of TN risk among males, while high LDL levels were an independent predictor of TNs among females, and other risk factors were not significantly changed. Conclusion TN detection rates were high among adults in Southwestern China. Female, elderly individuals, individuals exhibiting central obesity, and those with high levels of fasting plasma glucose are more likely to develop TN.

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Section: Discussionmentioning

confidence: 99%

Detection of Thyroid Nodule Prevalence and Associated Risk Factors in Southwest China: A Study of 45,023 Individuals Undergoing Physical Examinations

Liu¹,

Li²,

Wang³

et al. 2023

DMSO

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“…While the availability of images has simplified access and the protocols of consultations in radiology, with variable implications in different subspecialty areas [ 3 , 4 , 5 ], this has also become true in pathology, with some studies exploring the issue of discordance and impact on patients’ treatment [ 6 , 7 , 8 , 9 ] or legal issues [ 10 , 11 ]. Moreover, the innovation and development of digital pathology have increased opportunities for second opinion consultation when reviewing complex cases and more practically for routine activities or intraoperative frozen sections [ 12 ] and on-site diagnostics [ 13 , 14 ]. However, little is known about second opinion consultation activity in transplantation, and even less is known about it in donor assessment.…”

Section: Introductionmentioning

confidence: 99%

Second Opinion in the Italian Organ Procurement Transplantation: The Pathologist Is In

Eccher

Malvi

Novelli

et al. 2023

Clinics and Practice

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Second opinion consultation is a well-established practice in different clinical settings of diagnostic medicine. However, little is known about second opinion consultation activity in transplantation, and even less is known about it concerning donor assessment. The consultations provided by the second opinion service led to the safer and homogeneous management of donors with a history of malignancy or ongoing neoplasm by transplant centers. Indeed, two of the most important aspects are the reduction of semantic differences in cancer reporting and the standardization of procedures, which are mainly due to the different settings and logistics of different pathology services. This article aims to discuss the role and the future of the second opinion in Italy during organ procurement, highlighting the critical issues and areas for improvement.

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“…When chest CT or 18 F-FDG PET were arranged to survey malignancy [ 15 , 16 ], thyroid mass might be identified incidentally. Based on the current recommendations from American Thyroid Association (ATA), fine needle aspiration (FNA) was probably perceived to define the benign or malignant nature of the thyroid incidentaloma [ 17 , 18 ]. Once the patient was diagnosed of thyroid cancer, a decision had to be reached as to whether LT surgery should be delayed [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of Thyroid Incidentaloma on Liver Transplant: A Study of 1010 Recipients at a Single Center

et al. 2022

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Background Thyroid incidentalomas are typically nonpalpable thyroid nodules discovered during radiographic evaluation for a non-thyroid issue. Thyroid incidentalomas visualized by computed tomography (CT) and 18 F-flurodeoxyglucose (FDG) positron emission tomography (PET) before living donor liver transplantation (LDLT) are rare. The aim of the study was to analyze the clinical impact of thyroid incidentalomas discovered prior to transplantation. Material/Methods This retrospective study recruited 1010 patients undergoing LDLT between 2010 and 2019. CT was performed on each patient, whereas PET was performed on randomized patients (n=498). Results The prevalence and malignant risk of thyroid incidentaloma on CT was 2.3% (23/1010) and 13.0% (3/23), respectively. The prevalence of thyroid incidentaloma on PET was 3.0% (15/498). Approximately half of the FDG uptake on PET was diffuse uptake (n=7), whereas the other half was focal uptake (n=8). The malignant risk of PET incidentaloma with focal FDG uptake was 37.5% (3/8). Four asymptomatic thyroid cancers were identified incidentally. After total thyroidectomy followed by LDLT, these patients maintained cancer-free status. Conclusions Thyroid incidentalomas occurred at a rate of 2–3% in LDLT candidates. The malignant risk was 13.0% on CT incidentaloma, and 37.5% on PET incidentaloma with focal FDG uptake. Curative treatment of incidental thyroid cancer followed by LDLT without delay can achieve a favorable prognosis.

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Thyroid Fine-Needle Aspiration Cytology: Focusing on Adherence to Guidelines and Hospital Organization

Cited by 5 publications

References 28 publications

Detection of Thyroid Nodule Prevalence and Associated Risk Factors in Southwest China: A Study of 45,023 Individuals Undergoing Physical Examinations

Detection of Thyroid Nodule Prevalence and Associated Risk Factors in Southwest China: A Study of 45,023 Individuals Undergoing Physical Examinations

Second Opinion in the Italian Organ Procurement Transplantation: The Pathologist Is In

Impact of Thyroid Incidentaloma on Liver Transplant: A Study of 1010 Recipients at a Single Center

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