Thyroid Function after Radiotherapy and Total Laryngectomy in the Treatment of Carcinoma of the Larynx

Lavelle, R. J.

doi:10.1177/000348947108000424

Cited by 20 publications

(23 citation statements)

References 2 publications

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“…It coincides with the morphological evidence that dense bodies are increased in these thyroid tissues (Heymann, 1966;Bocker & Schofer, 1976). In Graves' thyroids, the excess iodide, which is known to inhibit the thyroidal hormone secretion, decreased the protease activities, as reported previously (Yoshinari et al, 1983), and the irradiated thyroids, which is known to elicit latent hypothyroidism (Labelle, 1971;Palmar et al, 1981), had low protease activities. These findings suggest that the thyroids with stimulated secretory activities had high protease activities.…”

Section: Discussionsupporting

confidence: 78%

Acid Thyroglobulin Protease Activities in Human Diseased Thyroid Glands

Yoshinari

Okamura

Shiroozu

et al. 1987

Clinical Endocrinology

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The lysosomal acid protease is thought to be a main enzyme in hydrolysis of thyroglobulin. The protease activity of lysosome-rich fractions of various diseased thyroid glands were assayed by the sensitive and reproducible method developed in our laboratory. They included 78 diseased thyroid glands; 37 thyrotoxic goitres, five irradiated thyroids, five Hashimoto's thyroiditis, one granulomatous thyroiditis, six multinodular goitres, 14 'cold' adenomas, four 'hot' adenomas with three paranodular tissues, and six carcinomas. Fifteen paranodular tissues of cold and solitary thyroid nodules were served as controls. The protease activities were significantly increased in thyroid tissues of thyrotoxic goitres, Hashimoto's thyroiditis, adenomas and adenocarcinomas. In thyrotoxic goitres, the protease activity correlated well with the mean area size of colloid follicles. The 'hot' adenomas had higher protease activity than 'cold' ones. The protease activity of multinodular goitres was nearly normal. Only the irradiated thyroid glands had low protease activities. Therefore the high protease activities in hyperfunctioning goitres seem to reflect hormone secretory activities. On the other hand, cold neoplastic goitres seem to have lysosomal protease activities which are not associated with thyroidal secretory process. The assay of acid protease activity will be useful to understand the pathophysiology of lysosomal system in diseased thyroid glands.

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Section: Discussionsupporting

confidence: 78%

Acid Thyroglobulin Protease Activities in Human Diseased Thyroid Glands

Yoshinari

Okamura

Shiroozu

et al. 1987

Clinical Endocrinology

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“…Hypothyroidism after laryngectomy with hemithyroidectomy and isthmusectomy is attributed to vascular compromise of the remaining thyroid lobe 12 . The long‐term incidence of postirradiation hypothyroidism in patients with head and neck cancer who did not undergo surgical resection has been reported as 20% and 27% at 5 and 10 year follow‐up 13 .…”

Section: Discussionmentioning

confidence: 99%

“…Hypothyroidism after laryngectomy with hemithyroidectomy and isthmusectomy is attributed to vascular compromise of the remaining thyroid lobe. 12 The longterm incidence of postirradiation hypothyroidism in patients with head and neck cancer who did not undergo surgical resection has been reported as 20% and 27% at 5 and 10 year follow-up. 13 Addition of surgery to radiation therapy significantly increases the overall risk of hypothyroidism, 13 and combined laryngectomy/hemithyroidectomy with subsequent radiation therapy has been shown to result in permanent hypothyroidism in as many as 70% of patients.…”

Section: Discussionmentioning

confidence: 99%

Predictors of Thyroid Gland Invasion in Glottic Squamous Cell Carcinoma

et al. 2005

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Preoperative assessment of TVC mobility and extent of SGE are significant correlates of thyroid gland invasion by SCC of the glottis. Distinct patterns of laryngeal spread are associated with thyroid gland invasion. Prophylactic hemithyroidectomy with isthmusectomy is indicated for glottic SCC in the preoperative setting of a fixed TVC and SGE greater than 15 mm. Additional study correlating patterns of laryngeal spread with thyroid gland invasion will add to these data in determining when to selectively perform thyroidectomy in this setting.

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“…Lavelle [2] reported a series of patients who had preoperative radiation therapy for carcinoma of the larynx followed by total laryngectomy and hemithyroidectomy on the side of the lesion. Four patients developed frank myxedematous changes which prompted him to advocate thyroid function tests on all patients undergoing this combined therapy.…”

Section: Discussionmentioning

confidence: 99%

Myxedema coma and inappropriate antidiuretic hormone secretion after deep neck irradiation: Clinical implications and report of a case

Formeister¹,

Sako²,

Razack³

et al. 1978

Journal of Surgical Oncology

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A case report is presented in which myxedema coma and inappropriate antidiuretic hormone secretion developed as a result of radiation therapy and surgery to the neck area in a patient with recurrent metastatic squamous cell carcinoma of the floor of the mouth. Laboratory findings of low thyroxine level and the findings of persistent hyponatremia and hypoosmolality of serum in spite of persistent sodium loss in the urine were helpful in diagnosing the problem. Treatment included thyroid hormone replacement and fluid restriction resulting in complete reversal of her condition. We believe that patients with head and neck cancer who have undergone a course of radiation to the neck, and particularly when thyroid function might have been altered by previous subtotal thyroidectomy as part of a curative resection, should be carefully followed with periodic thyroid function assays and serum electrolytes with particular attention to serum sodium values.

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Thyroid Function after Radiotherapy and Total Laryngectomy in the Treatment of Carcinoma of the Larynx

Cited by 20 publications

References 2 publications

Acid Thyroglobulin Protease Activities in Human Diseased Thyroid Glands

Acid Thyroglobulin Protease Activities in Human Diseased Thyroid Glands

Predictors of Thyroid Gland Invasion in Glottic Squamous Cell Carcinoma

Myxedema coma and inappropriate antidiuretic hormone secretion after deep neck irradiation: Clinical implications and report of a case

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