Thyroid function among women with gestational trophoblastic diseases. A cross-sectional study

Düğeroğlu, Harun; Özgenoğlu, Murat

doi:10.1590/1516-3180.2018.0481090519

Cited by 9 publications

(4 citation statements)

References 24 publications

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“…The women's clinical state was not assessed in this study, which solely looked at biochemical hyperthyroidism. 12 The discovery of greater incidence of biochemical hyperthyroidism in CM supports the findings of the previously mentioned 2015 US study. 20 Several research have investigated GTD hyperthyroidism's pathophysiology.…”

Section: Discussionsupporting

confidence: 79%

Hyperthyroidism Secondary to Gestational Trophoblastic Disease : A Literature Review

Bagus Sentosa

2023

JARMHS

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Gestational trophoblastic disease (GTD) is a rare form of pregnancy-related cancer that is effectively treatable. GTD is accompanied by the potentially fatal complication of hyperthyroidism. We created a review consisting of five case reports. This case report was conducted on women who became pregnant when they were >35 years old. They showed consistent laboratory results, in which there was an increase in hCG levels. TSH and thyroid stimulating antibodies cannot account for the hyperthyroidism associated with GTD. The source of the thyroid stimulating agent is trophoblastic tissue. The thyrotropic effects of ?-hCG mediate GTD hyperthyroidism. Other research examined the prevalence of hyperthyroidism in women with normal pregnancy, hydatidiform mole, and choriocarcinoma who had ?-hCG serum levels below 100,000 IU/ml. Early prenatal screening may significantly reduce hyperthyroidism rates. Thyroid hormone synthesis inhibitors treat hyperthyroidism in pregnancy. Thioamides, propylthiouracil (PTU), and methimazole (MMI) are the most prevalent U.S. antithyroid medications (ATD). Plasmaphoresis may be an option for people who are resistant to therapy or need emergency surgery. GTD can cause fatal hyperthyroidism. Anti-thyroid medicines can handle most GTD hyperthyroidism. Surgery may be a possibility for patients refractory to medical treatment.

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Section: Discussionsupporting

confidence: 79%

Hyperthyroidism Secondary to Gestational Trophoblastic Disease : A Literature Review

Bagus Sentosa

2023

JARMHS

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“…According to previous several studies, hyperthyroidism is one of complications of GTN. In this study, 8 (5%) GTN patients had hyperthyroidism and this was attributed to the molecular similarity of hCG with Thyroid-Stimulating Hormone (TSH), causing crossreactivity with the TSH receptor and leading to the stimulation of the thyroid gland [12,13].…”

Section: Discussionmentioning

confidence: 90%

Characteristics of Referral Patients with Gestational Trophoblastic Neoplasia in Dr. Hasan Sadikin General Hospital Bandung

Mantilidewi,

Zaenudin,

Harsono

et al. 2023

Indonesian Journal of Cancer

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Background: : Gestational trophoblastic disease (GTD) is a heterogeneous group of lesions caused by abnormal trophoblast proliferation and the malignant form is called gestational trophoblastic neoplasia (GTN). Dr. Hasan Sadikin General Hospital, located in Bandung, West Java, is one of the main cancer referral hospitals in Indonesia. Consequently, the characteristics of GTN patients in this hospital can represent the general population in the province. This study aimed to elaborate on the characteristics of referral patients with GTN in Dr. Hasan Sadikin General Hospital.Methods: : Medical records of post-molar GTN patients in Dr. Hasan Sadikin General Hospital from between January 2019 to December 2020 were collected and analyzed. GTN was diagnosed according to the International Federation in Gynecology and Obstetrics (FIGO) criteria. Additionally, both the sociodemographic and clinical characteristics of patients were evaluated.Results: The results showed that among the 160 participants in this study, the overall mean age was 33±8.7 years, with a mean βhCG level of 241,461.81±630,557.90 mIU/mL. Moreover, approximately 16.3% had gestosis and 5% were diagnosed with hyperthyroidism. The majority of post-molar observations at the hospital were not carried out according to standards, with only 8.1% of patients receiving optimal surveillance. About 56.8% visited the hospital due to vaginal bleeding, while most histopathological results showed complete hydatidiform moles (44.4%), and choriocarcinomas (16.3%). Most of the patients were diagnosed as stage I (81.9%), had lowrisk FIGO scores (80.6%), and were treated with methotrexate (80.6%).Conclusions: GTN patients in Dr. Hasan Sadikin General Hospital showed clinical characteristics consistent with previous studies. The low percentage of patients receiving optimal post-molar surveillance could cause delayed referral. This suboptimal surveillance might be due to the high cost of βhCG testing, lack of facilities, and low patient compliance in West Java

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“…The difference between hyperthyroidism in whole moles and partial moles illustrates how hyperthyroidism in GTD can be missed in the absence of routine biochemical screening. In a Turkish cross-sectional study [17], thyroid function was evaluated in women with GTD, and outcomes in PM and CM were compared. When compared to women with a pathologically confirmed diagnosis of PM, women with CM had greater total T4 (mean 17.04 vs 2.04), higher free T4 (mean 2.15 vs 1.64), and lower TSH (mean 0.28 vs 0.91).…”

Section: Temporal Trends Of Hyperthyroidism In Gtdmentioning

confidence: 99%

Hyperthyroidism in Gestational Trophoblastic Disease: Review Article

Sanjaya

2023

Int J Res Rev

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Gestational trophoblastic disease (GTD) is a collection of illnesses connected to pregnancy that result from aberrant placental trophoblast growth. Some GTD patients experience the rare but possibly fatal consequence of hyperthyroidism, which calls for prompt diagnosis and treatment. There is very little research on hyperthyroidism in GTD. This review examines the epidemiology, pathogenesis, and treatment of this phenomenon. The pathogenesis of hyperthyroidism in GTD has received extensive research. The trophoblastic tissue of the placenta secretes an excessive amount of hCG, which is structurally related to thyroid-stimulating hormone and has increased thyrotropic activity. Worldwide, there are different rates of hyperthyroidism in GTD, with lower rates related to high prenatal screening uptake and early GTD discovery. We were unable to pinpoint any specific risk factors for hyperthyroidism in GTD. Although surgical removal of the uterus can definitively treat hyperthyroidism, serious consequences in GTD have been recorded, including thyroid storm-induced multi-organ failure, ARDS, and pulmonary hypertension. To stop the onset of hyperthyroidism and the difficulties that go along with it, early GTD identification is essential. Women receiving surgery for GTD should be aware of hyperthyroidism as a critical postoperative factor that needs to be adequately managed. Future research should examine the elements contributing to hyperthyroidism in GTD as this may help identify high-risk female patients early. Keywords: [Gestational trophoblastic disease, Molar pregnancy, Hyperthyroidism, Hydatidiform mole, Pregnancy]

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Thyroid function among women with gestational trophoblastic diseases. A cross-sectional study

Cited by 9 publications

References 24 publications

Hyperthyroidism Secondary to Gestational Trophoblastic Disease : A Literature Review

Hyperthyroidism Secondary to Gestational Trophoblastic Disease : A Literature Review

Characteristics of Referral Patients with Gestational Trophoblastic Neoplasia in Dr. Hasan Sadikin General Hospital Bandung

Hyperthyroidism in Gestational Trophoblastic Disease: Review Article

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