Thyroid function and interferon treatment in chronic hepatitis C.

Abstract

8 Gibson GR, Cummings JH, Macfarlane GT. Use of a three-stage continuous culture system to study the effect of mucin on dissimilatory sulfate reduction and methanogenesis by mixed populations of human gut bacteria. Appl Environ Microbiol 1988; 54: 2750-5. 9 Christl SU, Gibson GR, Cummings JH. Role of dietary sulphate in the regulation of methanogenesis in the human large intestine. Gut 1992; 33: 1234-8. 10 Oremland RS, Taylor BF. Sulfate reduction and methanogenesis in marine sediments. Geochimica et Cosmochimica Acta 1978; 42: 209-14. 11 Kristjansson JK, Schonheit P, Thauer RK. Different K, values for hydrogen of methanogenic bacteria and sulfate reducing bacteria: an explanation for the apparent inhibition of methanogenesis by sulfate.

Exacerbation of Thyroid Autoimmunity by Interferon .ALPHA. Treatment in Patients with Chronic Viral Hepatitis: Our Studies and Review of the Literature.

“…There are, however, contradictory data indicating that leukocyte-derived IFNa does not lead to HLA-DR antigen expression on thyrocytes [2]. The ability of recombinant IFNa to induce thyroid autoimmunity in vivo [11,12,14,19,[21][22][23][24][25][26][27][28] suggests that IFNy contamination may not be the sole reason. Furthermore, according to the report by Burman et al [9] 6 X 106 U of natural IFNa contains approximately 10 U of IFNy.…”

Transient Hypothyroidism in a Child Treated With Alpha-Interferon for Chronic Hepatitis B Infection

“…In some cases, where antithyroid antibodies have not been detected, a direct inhibition of thyroid hormone production by alpha-interferon may have occurred. 3,14,15 In addition, studies suggest that autoimmune thyroid disease is more common with chronic hepatitis C, and therefore these patients may be especially predisposed to developing thyroid dysfunction during treatment with alpha-interferon. Nevertheless, thyroid dysfunction may develop during treatment of patients with chronic hepatitis B.…”

An Underdiagnosed Hypothyroidism and Its Clinical Significance in Patients with Advanced Hepatocellular Carcinoma

“…Many factors could contribute to the increase in hypothyroidism incidence in patients with advanced HCC. Interferon therapy, previously used regularly in patients with chronic hepatitis C, can cause hypothyroidism [8–13]. Transarterial chemoembolization (TACE), a standard treatment for intermediate‐stage HCC, can also cause thyroid function disorders, although temporarily in most patients [14].…”