Thyroid Function and Plasma Concentrations of Polyhalogenated Compounds in Inuit Adults

Dallaire, Renée; Dewailly, Éric; Pereg, Daria; Déry, Steve; Ayotte, Pierre

doi:10.1289/ehp.0900633

Cited by 192 publications

(166 citation statements)

References 40 publications

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“…So far, epidemiologic studies have focused on the potential effect of PFCs on human thyroid functions. Several large-scale surveys of Nunavik permanent residents (Dallaire et al 2009), US. general adult population (Melzer et al 2010), and children living near a chemical plant of USA (Lopez-Espinosa et al 2012) suggested the association of increased serum PFCs with abnormal THs levels and thyroid diseases.…”

Section: Introductionmentioning

confidence: 99%

Structure–activity relations in binding of perfluoroalkyl compounds to human thyroid hormone T3 receptor

et al. 2014

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Section: Introductionmentioning

confidence: 99%

Structure–activity relations in binding of perfluoroalkyl compounds to human thyroid hormone T3 receptor

et al. 2014

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“…It has been reported in other publications that TH concentrations could correlate positively or negatively with PBDE or PCB concentrations, and the actual relationship may be dependent on the exposure level, population characteristics, the specific congeners that are measured, and other study characteristics [79][80][81][82][83].…”

Section: Relationships Between Th Concentrations and Pbde Pcb And Dmentioning

confidence: 99%

“…It has been observed in rats and seals that PCBs can disturb thyroid homeostasis and TH functions [30]. PCBs can also disturb TH homeostasis in humans, but the reports regarding this are few and their results have not been consistent [31][32][33][34].…”

Section: Introductionmentioning

confidence: 99%

Polybrominated diphenyl ether, polychlorinated biphenyl, and dechlorane plus concentrations in human serum, and their relationships with thyroid hormones.

Wang¹,

Xu²,

Li³

et al. 2017

Environ Risk Assess Remediat

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Persistent halogenated organic compounds, including polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), and dechlorane plus (DP), were determined in human serum collected in Weifang and Nanning, China, and the relationships between their concentrations and thyroid hormone concentrations were determined. The total PBDE (∑ 10 PBDEs), total PCB (∑ 14 PCBs), and total DP (∑DP) concentrations were higher in Weifang (medians 220, 4.3, and 2.2 ng/g lipid, respectively) than in Nanning (medians 180, 1.9, and 1.5 ng/g lipid, respectively). The donors' ages correlated with ∑ 14 PCBs but not with ∑ 10 PBDEs or ∑DP in Weifang. Age positively correlated with ∑ 10 PBDEs but not ∑ 14 PCBs and ∑DP in Nanning. The correlations between the individual PBDE, PCB, and DP congener and thyroid hormone concentrations were analyzed by stepwise multiple linear regression after log 2 -transforming the variables. Triiodothyronine (T3) concentrations were associated with BDE-99 concentrations and ∑DP in Weifang but with BDE-153 concentrations and ∑ 10 PBDEs in Nanning. A positive correlation was found, for the first time, between anti-DP and free-T3 concentrations in Weifang, but free-T3 concentrations correlated with PCB-118 and PCB-170 concentrations in Nanning. Thyroxine (T4) concentrations correlated with total dioxin-like PCB concentrations in Weifang but with PCB-156 concentrations in Nanning. No significant correlations were found between the analyte and free-T4 concentrations in Weifang, but negative correlations were found between free-T4 and total dioxin-like PCB and BDE-190 concentrations in Nanning. No significant correlations were found between the analyte and thyroid-stimulating hormone (TSH) concentrations in Weifang but negative correlations were found between ∑ 10 PBDEs and the TSH concentrations in Nanning. The correlations between the analyte and thyroid hormone concentrations followed different trends in Weifang and Nanning but were similar to those that have been found in animal and epidemiological studies. AbstractPolybrominated diphenyl ether, polychlorinated biphenyl, and dechlorane plus concentrations in human serum, and their relationships with thyroid hormones.

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“…Many epidemiological studies that evaluate associations of PBDEs exposure and thyroid hormones in adults and newborns have been published previously, but their results are not consistent (Hagmar et al, 2001;Mazdai et al, 2003;Herbstman et al, 2008;Turyk et al, 2008;Dallaire et al, 2009;Kim et al, 2009;Roze et al, 2009;Chevrier et al, 2010;Zhang et al, 2010;Chevrier et al, 2011;Eggesbø et al, 2011;Gascon et al, 2011;Lin et al, 2011). A few studies report the negative impact of cord blood PBDEs on levels of human thyroid hormones after in utero exposure (Herbstman et al, 2008;Lin et al, 2011), but most studies conducted in humans have found no correlations.…”

Section: Pbdes and Thyroid Hormonesmentioning

confidence: 99%

Impact of Brominated POPs on the Neurodevelopment and Thyroid Hormones of Young Children in an Indoor Environment—A Review

Chao

Huang

Hsu

et al. 2014

Aerosol Air Qual. Res.

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The goal of this report is to evaluate brominated persistent organic pollutants (POPs) in the indoor air and dust to further assess their health effects on thyroid hormones and neurodevelopment in infants, toddlers, and young children. This category of brominated POPs includes polybrmonated diphenyl ethers (PBDEs), hexabromocyclododecanes (HBCDs), polybrominated biphenyls (PBBs), and polybrominated dibenzo-p-dioxins (PBDD/DFs). These organobromines are lipophilic compounds which resist physical and chemical degradation in the environment and biota, and so easily bioaccumulate in adipose tissue. Brominated POPs, particularly in brominated fire retardants (BFRs) such as PBDEs, HBCDs, and PBBs, are ubiquitous in indoor environments due to their inadvertent release from certain consumer products. Some of these organobromines have been recognized in some in-vitro and in-vivo studies to be neurotoxins and disrupt thyroid hormones, although the evidence from actual epidemiological studies is contradicted and inconsistent, especially for infants, toddlers, and young children, who are particularly vulnerable to these substances as they spend most of their time in the home. This report focuses on exposure to PBDEs, HBCDs, PBBs, and PBDD/DFs in the indoor dust and on the indoor aerosol, to explore their association with human health, particularly the disruption of thyroid hormones and neurodevelopment in early childhood.

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Thyroid Function and Plasma Concentrations of Polyhalogenated Compounds in Inuit Adults

Cited by 192 publications

References 40 publications

Structure–activity relations in binding of perfluoroalkyl compounds to human thyroid hormone T3 receptor

Structure–activity relations in binding of perfluoroalkyl compounds to human thyroid hormone T3 receptor

Polybrominated diphenyl ether, polychlorinated biphenyl, and dechlorane plus concentrations in human serum, and their relationships with thyroid hormones.

Impact of Brominated POPs on the Neurodevelopment and Thyroid Hormones of Young Children in an Indoor Environment—A Review

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