Thyroid Function and Prevalence of Anti-Thyroid Antibodies in Iranian Patients with Type 1 Diabetes Mellitus: Influences of Age and Sex

Sharifi, Faranak; Hashtroodi, Leila Ghasemi; Jaberi, Yahya

doi:10.1016/j.clim.2007.03.214

Cited by 15 publications

(19 citation statements)

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“…It is also believed that the sexual hormone receptors have an impact on the functions of inflammatory and immune cells (35). The results of this study are compatible with other studies who did not find any difference in the distribution of the groups studied by gender (13,17,32). The results of this study showed that the mean age of patients with diabetes type I was (17.9 ± 18.5) years while the mean age of patients with type II diabetes (56.3±10.2) years, while in the control group was (37.7 ± 10.9) years, with a significant difference was noticed between then , with the p-value (p < 0.0001).…”

Section: Discussionsupporting

confidence: 83%

Study a level of TNF-α and INF-Ƴ in patients with Type I and II Diabetes Mellitus in diayla governorate

Saleh¹,

Khalaf²

2017

DJPS

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The aim of this study was to determine a level of TNF-α and INF-Ƴ in patients with Type I and Type II Diabetes Mellitus, this cytokines measured by enzyme-linked immunosorbent assay (ELISA). A total of 70 patients and 20 healthy volunteers were included in this study, collected during the period from the beginning of August 2015 to the end of May 2016. The results showed a significant increase in the concentration of INF-Y in the serum of both types diabetes mellitus with the control group there were, the level of INF-Y in patients with type I and type II diabetes mellitus was 740.1, 738.5 pg / mL respectively while the level in control group was 431.9 pg / mL .As well as the results showed a significant increase in the concentration of TNF-α in the serum of both types diabetes mellitus than control group there were, the level of TNF-α in patients with type I and type II diabetes mellitus was 339.2 , 228.4 pg / mL respectively while the level in control group was107.8 pg / ml. Key word: Diabetes Mellitus , TNF-α , INF-Ƴ . Study a level of TNF-α and INF-Ƴ in patients with

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Section: Discussionsupporting

confidence: 83%

Study a level of TNF-α and INF-Ƴ in patients with Type I and II Diabetes Mellitus in diayla governorate

Saleh¹,

Khalaf²

2017

DJPS

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“…Increased anti-TG were associated with increased statistically significant different with normal TSH levels. This finding Sharifi et al [22] who found diabetic patients had positive anti anti-TG and also was associated high prevalence of anti-TPO American Hispanic patients [23]. al.…”

Section: Discussionmentioning

confidence: 67%

Thyroid Dysfunction and Morphological Abnormalities in Patients with Type 1 Diabetes Mellitus

Al-Din¹,

Mohamed²,

El-Sawy³

et al. 2015

AJIM

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Background: Type 1 diabetes mellitus is an autoimmune disease. Several studies have documented great variations in the prevalence of thyroid dysfunction and autoimmune thyroid disease (AITD) in type 1 diabetic patients. Undiagnosed thyroid dysfunction has negative impact on the metabolic control and will aggravate the cardiovascular disorders. Objectives: We aimed to investigate the presence of thyroid dysfunction and the associated morphological abnormalities in type 1 diabetes mellitus. Methods: 80 type 1 diabetic patients without overt thyroid disease attending the outpatient clinic of diabetes at Kasr Al Aini hospital, faculty of medicine, Cairo University were enrolled in the study. Thyroid functions (TSH, FT4, FT3), anti thyroid peroxidase (anti-TPO) and anti thyroglobulin (anti-TG) antibodies were measured in all patients. Thyroid ultrasound was performed in all patients and in 50 healthy control subjects. The data was analyzed and expressed in terms of mean ± SD. Pearson correlation was performed to establish the relationship between different variables. Results: 52 of 80 patients (65%) showed high TSH levels with mean (12.37±3.9 mIU/ml) and 25 patients (31.3%) showed positive anti-TG anti-TPO levels with mean (906 ± 184.3, 628 ±137.5 IU/ml) respectively. The high TSH levels were statistically significantly associated with high anti-TG levels and anti-TPO levels with (mean 570.23± 372.41, 366.52±281.34 IU/ml) respectively with P-value < 0.001. There was significant increase in the gland volume in diabetic patients with mean (3.4±1.5 ml) versus (2.9±0.9 ml) in the control group, P-value <0.046. Also 25% of patients showed heterogenous hypoechogenic gland texture versus 6 % in the control group which was statistically significantly different, P-value = 0.008 and 50% of the patients showed increase in gland vascularity versus 12% in the control group which was statistically significantly different with P-value <0.001. These morphological abnormalities were associated with high (TSH, anti-TPO and anti-TG) levels but weren't significant. High TSH levels were strongly positively correlated with anti-TPO and anti-TG, r = (0.84, 0.83) respectively, P-value <0.001. Conclusions: Type 1 diabetic patients had high incidence of thyroid dysfunction and AITD associated with morphological abnormalities of the thyroid gland. So we recommend screening for thyroid dysfunction in all patients with type 1 DM to avoid additional cardiovascular risk factors.

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“…In another study performed in Bratislava, 40-50% of patients with different types of diabetes had autoimmune thyroiditis (48). The incidence of histologic findings of autoimmune thyroid disease in diabetic patients increases with age (49). Several other studies have confirmed the coincidence of autoimmune thyroiditis and latent or overt diabetes (50) and relatives of patients with type I diabetes have an increased incidence of HT (51).…”

Section: Related Disordersmentioning

confidence: 70%

Hashimoto's Thyroiditis in Children and Adolescents

Sarı¹,

Karaoğlu²,

Yeşilkaya³

2011

Autoimmune Disorders - Current Concepts and Advances From Bedside to Mechanistic Insights

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Thyroid Function and Prevalence of Anti-Thyroid Antibodies in Iranian Patients with Type 1 Diabetes Mellitus: Influences of Age and Sex

Cited by 15 publications

References 0 publications

Study a level of TNF-α and INF-Ƴ in patients with Type I and II Diabetes Mellitus in diayla governorate

Study a level of TNF-α and INF-Ƴ in patients with Type I and II Diabetes Mellitus in diayla governorate

Thyroid Dysfunction and Morphological Abnormalities in Patients with Type 1 Diabetes Mellitus

Hashimoto's Thyroiditis in Children and Adolescents

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