1991
DOI: 10.1016/0891-4222(91)90013-i
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Thyroid function in down syndrome

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Cited by 56 publications
(27 citation statements)
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“…In addition to the increased risk of developing autoimmune hypothyroidism with age (2,6), children with DS have a higher chance of displaying a mild, isolated increase in thyroid-stimulating hormone (TSH) in the absence of low free thyroxine (FT4) or overt hypothyroid symptoms (7,8). This phenomenon, of uncertain etiology, can be referred to as subclinical hypothyroidism (SH) and seems usually to be transitory and self-limiting without treatment (9,10).…”
Section: T He Prevalence Of Medical Conditions In Individuals Withmentioning
confidence: 99%
“…In addition to the increased risk of developing autoimmune hypothyroidism with age (2,6), children with DS have a higher chance of displaying a mild, isolated increase in thyroid-stimulating hormone (TSH) in the absence of low free thyroxine (FT4) or overt hypothyroid symptoms (7,8). This phenomenon, of uncertain etiology, can be referred to as subclinical hypothyroidism (SH) and seems usually to be transitory and self-limiting without treatment (9,10).…”
Section: T He Prevalence Of Medical Conditions In Individuals Withmentioning
confidence: 99%
“…The most common endocrine disorder associated with DS involves the thyroid gland. 3 Individuals with DS exhibit a wide range of thyroid dysfunction. In general, thyroid disorders have been reported to have a prevalence of 3-54% in people with DS, with the frequency of thyroid dysfunction increasing with age.…”
Section: Introductionmentioning
confidence: 99%
“…The most common endocrine disorder associated with DS involves the thyroid gland. [5] Individuals with DS exhibit a wide range of thyroid dysfunction. The forms of hypothyroidism found in individuals with DS include congenital hypothyroidism (CHT), subclinical or 'compensated' hypothyroidism (SCH), transient and primary hypothyroidism, central hypothyroidism, thyroxin-binding globulin deficiency and chronic lymphocytic thyroiditis.…”
mentioning
confidence: 99%