Thyroid Function in Patients With Mammary Cancer

Edelstyn, G.A.; Lyons, Arnold R.; Welbourn, Richard

doi:10.1016/s0140-6736(58)91088-2

Cited by 41 publications

(13 citation statements)

References 5 publications

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“…This is in accord with the main findings of Edelstyn et al (1958) in cases of local disease. Indeed, we might on this evidence hazard the observation that thyroid dysfunction plays little part in the primary aetiology of mammary cancer, apart from the slight bias towards hypofunction demonstrated above.…”

Section: Discussionsupporting

confidence: 92%

“…From the diagram published in their paper, Edelstyn et al (1958) show an even greater bias towards hypofunction, for their group with local disease only the group most nearly comparable with our own. Of their 23 cases, 17 are in the Normal group, 4 in the Low, and 2 in the Very Low, making 26 per cent below Fraser's lower extremity of the Normal group.…”

Section: Resultssupporting

confidence: 76%

“…Between cholesterol and B or C the correlation was so small as to indicate no sensible relationship between these readings. The mean values of B (uptake 24th hour), C (excretion 6-24 hours), age, and cholesterol are given in Table III for each clinical stage, and in Table IV In the case of gland uptake, our experience (24th hour) corresponds very closely with that of Edelstyn et al (1958) For urinary excretion we have calculated the T-index of Fraser et al (1953) on 83 of our patients. Table V shows their distribution in terms of the five groupings used by Fraser.…”

Section: Resultsmentioning

confidence: 62%

“…He has lately been injecting solution of thyroid in and around the tumour, as well as giving thyroid combined with histidine (Loeser, 1960, personal communication). Recently, Edelstyn, Lyons, and Welbourn (1958) One hundred and nineteen women with various types of breast carcinoma were investigated by radioactive iodine (1311), and 98 of these had their blood cholesterol estimated also. In all these cases the neoplasm was still localised to the breast tissue or to regional glandular areas and had no distant metastases.…”

mentioning

confidence: 99%

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Thyroid Function in Relation to Mammary Cancer

Sicher¹,

Waterhouse²

1961

Br J Cancer

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THE direct or indirect influence of certain hormones, e.g. stilboestrol and testosterone, on the aetiology of malignancy has been well recognised for many years and has formed the basis of their extensive use in the management of this disease, particularly in attempting its control in advanced stages. Some of the cancers of breast and of prostate are good examples of tumours which are hormone dependent. But the role that the thyroid hormone plays is still uncertain. Beatson was the first, in 1896, to treat advanced carcinoma of breast with thyroid extract in addition to oophorectomy. Only in the last decade or so the result of a good deal of experimental work and clinical observation has been to suggest that thyroid secretion plays an important part in the evolution of cancer, particularly of the genitalia and the breast. Loeser (1954) states that the incidence of female breast carcinoma is far lower in allergic and hyperthyroid conditions than in hypothyroid women or after thyroidectomy. In his view, it is the low histamine content of the cells of hypothyroid women which increases the tendency to cancer formation. Spencer (1954), discussing iodine availability in cancer incidence, doubts whether a low metabolic rate or insufficiency of thyroid substance can be considered as a primary cause of cancer. He suggests, rather more vaguely, " that thyroid function (or dysfunction) may be associated with the susceptibility or immunity to cancer ". Sommers (1955), after examining autopsies of breast cancer cases and of about an equal number of adult women without cancer, found hyperplastic modification in one or more endocrine glands and their target organs. A noticeable exception was the thyroid gland, in which atrophy occurred more commonly with than without breast cancer. The thyroid atrophy was independent of the body weight. Dargent and Mayer (1955), surveying 71 cases of cancer of various sites, have attempted to demonstrate that thyroid secretion has a definite influence on the evolution of cancer, and warn that surgical treatment of goitre in a case of established malignancy should not be undertaken lightly. Dessaive (1956) in both his experimental work and clinical observations comes to a similar conclusion. From his study of 13,261 cancers seen in Liege it appears that simple thyroid conditions, particularly goitre, constitute a favourable element in the formation of cancer. The effect was found in women much more often than in men, and was especially noticeable in breast carcinoma. He also found that cancers which develop against a background of thyroid deficiency have a worse prognosis, and recommends full investigation before undertaking surgical or other treatment for simple thyroid disorder, in order to exclude the presence of a cancer which at -that time may be

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Section: Discussionsupporting

confidence: 92%

Section: Resultssupporting

confidence: 76%

Section: Resultsmentioning

confidence: 62%

mentioning

confidence: 99%

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Thyroid Function in Relation to Mammary Cancer

Sicher¹,

Waterhouse²

1961

Br J Cancer

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“…Edelstyn, Lyons and Welbourn (1958) observed such an association during routine studies with 1311 performed before hypophysectomy. It was noted that patients in whom the disease was confinied to the chest wall and local glandular areas had consistently higher indices of thyroid activity as judged by neck uptake, urinarv excretion and protein bound 1311 levels, than those patients in whom blood borne spread had taken place.…”

mentioning

confidence: 81%