Thyroid function in patients with breast cancer

Rasmusson, Bente; Feldt‐Rasmussen, Ulla; Hegedüs, L; Perrild, Hans; Bech, K; Høier‐Madsen, Mimi

doi:10.1016/0277-5379(87)90319-1

Cited by 59 publications

(39 citation statements)

References 20 publications

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“…Since Beatson (1) first described the use of thyroid extracts to treat patients with metastatic breast cancer over a century ago, a number of studies have investigated the association between thyroid disorders and breast cancer (2)(3)(4)(5)(6)(7)(8). However, despite extensive population studies, the results as a whole have been inconsistent.…”

Section: Introductionmentioning

confidence: 99%

Antithyroid peroxidase antibody positivity is associated with lower incidence of metastasis in breast cancer

Kemal

Demirağ

Ekiz

et al. 2015

Molecular and Clinical Oncology

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Abstract. Thyroid extracts were first used to treat patients with metastatic breast cancer over a century ago. Since then, a number of studies have investigated the association between thyroid disorders and breast cancer. The presence of antibodies to thyroid peroxidase (TPOab) was recently reported to be associated with improved outcome in these patients. The aim of the present study was to evaluate the association between TPOab positivity and clinicopathological characteristics in breast cancer patients. The study included 318 newly diagnosed cases of breast cancer treated at Ondokuz Mayis University Hospital, Samsun, Turkey, between 2008 and 2012. Serum thyroid-stimulating hormone, free triiodothyronine and free thyroxine levels were measured at the time of diagnosis. Of the 318 patients, 253 were considered to be TPOab-negative (TPOab ≤34 IU/ml) and 65 TPOab-positive (TPOab >34 IU/ml). No cases with distant metastases were found in the TPOab-positive group. However, 20 (7.9%) of the 253 patients displayed distant metastases in the TPOab-negative group (P=0.01). Therefore, TPOab positivity was found to be associated with a lower incidence of metastasis in breast cancer patients.

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Section: Introductionmentioning

confidence: 99%

Antithyroid peroxidase antibody positivity is associated with lower incidence of metastasis in breast cancer

Kemal

Demirağ

Ekiz

et al. 2015

Molecular and Clinical Oncology

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show abstract

“…b) Some of the tumour-associated autoantibodies may exhibit different binding specifities from those of the primary thyroid disorders. This phenomenon has been shown with antibodies against thyroid peroxidase (18) and with the newly discovered anti-MIC-l antibody in patients with SLE and hyperthyroidism (25). There have been some reports of coexistence of breast, pancreatic and colon cancer with thyroid disease (26)(27)(28)(29), either of the type of Hashimoto thyroiditis (27) or of hypo-, hyperthyroidism (29,30).…”

Section: Discussionmentioning

confidence: 72%

“…The production of ATA autoantibodies has been demonstrated in many malignancies including the breast, lung, gastric and colon adenocarcinomas (9, [16][17][18]. There is also evidence of increased risk of pancreatic cancer in hyperthyroid women with a standardized mortality ratio from pancreatic cancer as high as 2.6 (19).…”

Section: Discussionmentioning

confidence: 99%

Thyroid Autoantibodies and Thyroid Function in Patients with Pancreatic Adenocarcinoma

et al. 1997

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Pancreatic adenocarcinoma (PA) patients often present high serum titres of several autoantibodies including autoantibodies against [j-islet cells and insulin. In the present study we examined with an hemagglutination method the sera of 33 patients with PA for the presence of both anti-mitochondria1 and anti-thyroglobulin antithyroid autoantibodies (ATA). Twenty-six surgical patients with other non-malignant gastrointestinal tract (GI) disease (chronic pancreatitis or hernia) and 40 healthy volunteers were used as controls. Eight of the 33 PA patients were found to have ATA autoantibodies. whereas only one patient with chronic pancreatitis and 2 normal individuals had high serum ATA titres. The difference between the PA patients and either of the control groups was statistically significant ( p < 0.05). The production of autoantibodies could be attributed to impaired immunoregulation caused by the malignant cells.

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“…Although several different researchers have proposed models for breast cancer survival, none have provided the considerable impact of chronic diseases on breast cancer patients' longevity. Some research such as Rasmusson and Shering [43,44], Maruchi et al [45], and Lemaire et al [46] have asserted the existence of several breast cancer patients who had chronic diseases such as thyroid. This comprehensive research revealed that a breast cancer patient's longevity is directly affected by the condition of chronic diseases (such as diabetes, hypertension, and endocrine gland disorders such as hypo and hyper-thyroidism).…”

Section: Discussionmentioning

confidence: 99%

Survival analysis of breast cancer patients with different chronic diseases through parametric and semi-parametric approaches

Atashgar

Sheikhaliyan

Tajvidi

et al. 2018

Multidiscip Cancer Investig

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Thyroid function in patients with breast cancer

Cited by 59 publications

References 20 publications

Antithyroid peroxidase antibody positivity is associated with lower incidence of metastasis in breast cancer

Antithyroid peroxidase antibody positivity is associated with lower incidence of metastasis in breast cancer

Thyroid Autoantibodies and Thyroid Function in Patients with Pancreatic Adenocarcinoma

Survival analysis of breast cancer patients with different chronic diseases through parametric and semi-parametric approaches

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