Background: Cirrhosis of the liver may be compensated with no obvious complications or decompensated which accompanied by ascites, hematemesis, or renal impairment. Liver disease affects thyroid hormone metabolism, thyroid problems can impair liver functions, and several systemic diseases can affect both organs. Objectives: The aim of the current work was to study level of thyroid hormones in patients with liver cirrhosis and to evaluate the significance of thyroid hormone level and severity of liver cirrhosis. Patients and methods: This case control study included a total of 25 cirrhotic patients and equal number of age and gender matched controls, attending at