Thyroid function tests in metabolic syndrome

Chugh, Kiran; Goyal, Sandeep; Shankar, Vijay; Chugh, SN

doi:10.4103/2230-8210.102999

Cited by 22 publications

(15 citation statements)

References 14 publications

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“…Chugh K et al in a similar study reported high TSH levels in subjects with MetS and attributed the rise to thyroid receptor resistance, which may be a part of MetS. [15] There have been enough reports which support a correlation between TSH levels and components of MetS and thus substantiate our findings. Abdominal obesity is the major risk factor for the development of metabolic syndrome and in the assessment of cardiovascular disease.…”

Section: Discussionsupporting

confidence: 81%

A Study on Association between Thyroid Stimulating Hormone Levels and Metabolic Syndrome Components

2016

AIMDR

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Background: Since metabolic syndrome (MetS) and thyroid dysfunction (TD) are both characterized by a cluster of common abnormalities, it is possible that patients suffering from both disease entities might have compounded risk. This study was aimed to evaluate the pattern of TD in subjects with MetS and its relationship with components of the MetS. Methods: One hundred cases defined according to the International Diabetic Federation (IDF) criteria were evaluated for vital parameters, lipid and thyroid profile, along with other routine laboratory parameters. Results: There was a significant association of various metabolic syndrome parameters viz. body mass index(BMI), systolic blood pressure (SBP),diastolic blood pressure (DBP), total cholesterol(TC), triglycerides (TG) and fasting blood sugar(FBS) with TD (P<0.05). It was found that BMI, waist circumference (WC), SBP, total cholesterol (TC), triglyceride (TG) and FBS had significant (P<0.05) positive linear correlation whereas age and high density lipoprotein (HDL) had non-significant (P>0.05) negative correlation with thyroid stimulating hormone (TSH) levels. Conclusion: The prevalence of TD in patients with MetS was high; while subjects with SCH and elderly females were at increased risk.

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Section: Discussionsupporting

confidence: 81%

A Study on Association between Thyroid Stimulating Hormone Levels and Metabolic Syndrome Components

2016

AIMDR

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“…This differs from findings by some authors working in different regions and with different races. Workers in India [ 5 , 16 ], Taiwan [ 19 ] and Korea [ 18 ], found a high prevalence of sub clinical hypothyroidism in people with metabolic syndrome. Heima et al [ 23 ] working in Amsterdam also found an association between higher TSH levels and metabolic syndrome in euthyroid subjects.…”

Section: Discussionmentioning

confidence: 99%

Thyroid function in adult Nigerians with metabolic syndrome

2014

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IntroductionMetabolic syndrome and thyroid dysfunction are two common disorders encountered in the metabolic clinic. Recently, there has been increased interest in the association between the two disorders because of the similarities between symptoms of hypothyroidism and components of the metabolic syndrome. While some reports suggest that metabolic syndrome is associated with subclinical hypothyroidism, this concept is largely under investigated in Nigerian adults with metabolic syndrome. The aim of this study is to determine the thyroid function status of adult Nigerians with metabolic syndrome and determine the association, if any, between metabolic syndrome and thyroid function.MethodsThis was a cross sectional study of one hundred and fifty adults, members of staff of the College of Medicine of the University of Lagos. The participants were recruited using a cluster random sampling method. The Ethical Research & Review Committee of the institution approved the study protocol and signed informed consent was obtained from the participants. The statistics was analysed using the IBM SPSS Software of version 19.0. The Student's t test, Chi square test and multivariate regression analysis were employed for the analysis. Statistical significance was set at p < 0.05.ResultsThirty nine (twenty-six percent) of the study participants had metabolic syndrome and one hundred and eleven (seventy-four percent) of the study participants did not have metabolic syndrome, served as controls. Those who had metabolic syndrome group were significantly older (p = 0.03), metabolic syndrome was significantly associated with the female gender (p = 0.0002), higher systolic blood pressure (p = 0.0034), diastolic blood pressure (p = 0.0009), waist circumference (p < 0.0001), body mass index (p < 0.0001), waist-hip ratio (p = 0.003), fasting serum glucose (p = 0.0457) and free thyroxine (fT4) levels (p = 0.0496). Those with metabolic syndrome had significantly lower HDL (P = 0.004) and free triiodothyronine (fT3) levels (p = 0.037). There was no statistically significant difference in the thyroid stimulating hormone (TSH) levels between individuals with and without metabolic syndrome. Thirty-three percent of the metabolic syndrome cases had sick euthyroid syndrome (p= < 0.0001). In multivariate regression, waist circumference was significantly and inversely associated with the sick euthyroid syndrome (p = 0.011).ConclusionMetabolic syndrome is associated with the sick euthyroid syndrome in adult Nigerians. Abdominal obesity appears to be the link between metabolic syndrome and the sick euthyroid syndrome.

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“…In a large Chinese case control study, all components of the metabolic syndrome were associated with systematically higher TSH levels (Lai et al) (70). In a study done by Chugh et al,(2012) evaluating the thyroid function tests in individuals with metabolic syndrome to explore the possibility of thyroid receptor resistance, a significant increase was found in TSH levels in patients as compared to controls, while T 3 and T 4 levels were comparable in patients and controls concluding that raised TSH in patients with metabolic syndrome independent of lowered T 3 and T 4 suggests it to be a part and parcel of this syndrome (71). Another study done by Meher et al, (2013) found that body mass index, waist circumference, mean systolic pressure, diastolic pressure, fasting blood sugar, total cholesterol, LDL-C, triglycerides, and TSH were significantly higher, and FT3, free thyroxine (FT4) and HDL-C were significantly lower in the metabolic syndrome patients compared to the control group concluding that there is a significant association between subclinical hypothyroidism and metabolic syndrome, and it highlights the importance of thyroid function tests in patients with metabolic syndrome.(64,72).…”

Section: Discussionmentioning

confidence: 99%

The Prevalence of Metabolic Syndrome in Yemeni Patients with Hypothyroidism

Atef¹,

Bamashmos²

2016

ME-JFM

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Background: Yemen faces major challenges in improving the health status of its population as it is entering an epidemiological transition with rising non-communicable diseases e.g. obesity, diabetes and cardiovascular diseases (CVDs). We designed this study to find out the prevalence of Metabolic Syndrome (MS) and its components among Yemeni patients with hypothyroidism. Methods: 350 patients with past history or newly diagnosed hypothyroidism (diagnosed as having high TSH, and or low FT4 and FT3) (patients group) and 100 healthy euthyroid volunteers as (control group) attending the outpatients medical clinics at Al-Kuwait University hospital in Sana'a city. The patients and control groups underwent complete history and clinical examination including measurement of blood pressure and waist circumference. The laboratory parameters that were analyzed included fasting samples of plasma glucose, triglycerides, and HDL cholesterol The diagnosis of MS was based on the Adult Treatment Panel III criteria as the presence of at least 3 of the following: systolic BP >130 mm Hg and/or diastolic BP >85 mm Hg or on treatment for high BP, waist circumference >102 cm for men and >88 cm for women, fasting glucose >110 mg/dl or on diabetes treatment, triglycerides ?150 mg/dl, and HDL cholesterol <40 mg/dl in men and <50 mg/dl in women. Results: from 350 hypothyroid patients and 100 euthyroid volunteers included in this study 233 (66.6%) of hypothyroid patients had subclinical and 117 (33.4%) had overt hypothyroidism. MS was significantly higher in hypothyroid (37.4%), (76.3%) in patients with subclinical and 31 (23.6%) in patients with overt hypothyroidism, than in the euthyroid group (17%). The commonest occurring metabolic syndrome defined criterion in hypothyroid patients was central obesity 89 (67.9%), high blood pressure 88 (67.1%), reduced high density lipoprotein (61%), high serum triglyceride (59.5%) and raised fasting blood glucose (54.9%). Conclusion: Prevalence of MS is high among Yemeni patients with hypothyroidism and central obesity was the commonest co-morbidity. These findings highlight an urgent need to develop strategies for prevention, detection, and treatment of MS that could contribute to decreasing the prevalence of cardiovascular morbidity and mortality in hypothyroid patients.

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Thyroid function tests in metabolic syndrome

Cited by 22 publications

References 14 publications

A Study on Association between Thyroid Stimulating Hormone Levels and Metabolic Syndrome Components

A Study on Association between Thyroid Stimulating Hormone Levels and Metabolic Syndrome Components

Thyroid function in adult Nigerians with metabolic syndrome

The Prevalence of Metabolic Syndrome in Yemeni Patients with Hypothyroidism

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