Thyroid Gland Disease as a Comorbid Condition in COPD

Gümüş, Aziz; Özçelik, Neslihan; Kara, Bilge; Özyurt, Songül; Şahin, Ünal

doi:10.1155/2021/7479992

Cited by 7 publications

(4 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Literature findings previously reported a higher level of both anxiety and depression in the female population [47,48]. Thyroid gland dysfunction had been described as a comorbid condition in COPD [49], with possible higher prevalence in females compared to males [50].…”

Section: Plos Onementioning

confidence: 93%

Gender-specific disease trajectories prior to the onset of COPD allow individualized screening and early intervention

et al. 2023

View full text Add to dashboard Cite

Background Nation-wide hospitalization databases include diagnostic information at the level of an entire population over an extended period of time. Comorbidity network and early disease development can be unveiled. Chronic obstructive pulmonary disease (COPD) is an underdiagnosed condition for which it is crucial to identify early disease indicators. The identification of gender-specific conditions preceding the onset of COPD may reveal disease progression patterns allowing for early diagnosis and intervention. The objective of the study was to investigate the antecedent hospitalization history of patients newly diagnosed with COPD and to retrace a gender-specific trajectory of coded entities prior to the onset of COPD. Material and methods A population-wide hospitalization database including information about all hospitalizations in Switzerland between 2002 and 2018 was used. COPD cases were extracted from the database and comorbidities occurring prior to the onset of COPD identified. Comorbidities significantly over-represented in COPD compared with a 1:1, age- and sex-matched control population were identified and their longitudinal evolution was analyzed. Results Between 2002 and 2018, 697,714 hospitalizations with coded COPD were recorded in Switzerland. Sixty-two diagnoses were significantly over-represented before onset of COPD. These preceding comorbidities included both well-established conditions and novel links to COPD. Early pre-conditions included nicotine and alcohol abuse, obesity and cardiovascular diseases. Later comorbidities included atrial fibrillation, diseases of the genitourinary system and pneumonia. Atherosclerotic heart diseases were more prevalent in males, whereas hypothyroidism, varicose and intestinal disorders were more frequent in females. Disease trajectories were validated using an independent data set. Conclusions Gender-specific disease trajectories highlight early indicators and pathogenetic links between COPD and antecedent diseases and could allow for early detection and intervention.

show abstract

Section: Plos Onementioning

confidence: 93%

Gender-specific disease trajectories prior to the onset of COPD allow individualized screening and early intervention

et al. 2023

View full text Add to dashboard Cite

show abstract

“…As a result, both functional and anatomical thyroid gland disorders are commonly found as comorbid conditions in individuals with COPD. Additionally, the ongoing inflammation and hypoxemia experienced by COPD patients have an impact on thyroid function [ 13 ]. Given that COPD manifests with symptoms such as shortness of breath, weakness, loss of appetite, and weight loss, the clinical indicators of hyperthyroidism and/or hypothyroidism may be obscured, posing challenges in diagnosis.…”

Section: Reviewmentioning

confidence: 99%

“…Given that COPD manifests with symptoms such as shortness of breath, weakness, loss of appetite, and weight loss, the clinical indicators of hyperthyroidism and/or hypothyroidism may be obscured, posing challenges in diagnosis. Consequently, a delayed diagnosis of TGD can lead to adverse outcomes in COPD patients, as both hypothyroidism and hyperthyroidism negatively affect the respiratory system through distinct mechanisms [ 13 ]. A meticulous examination of the thyroid gland and the periodic measurement of thyroid function tests during the follow-up of COPD patients contribute to the early detection of TGD.…”

Section: Reviewmentioning

confidence: 99%

Prevalence and Impact of Thyroid Dysfunction in Patients With Chronic Pulmonary Obstructive Pulmonary Disorder: A Systematic Review and Meta-Analysis

Arrey Agbor,

Kari,

Chukka

et al. 2024

Cureus

View full text Add to dashboard Cite

Thyroid gland dysfunction (TGD) has been increasingly recognized as a potential comorbidity in patients with chronic obstructive pulmonary disease (COPD). This study was designed to determine the prevalence of TGD in COPD patients. This systematic review and meta-analysis was conducted according to the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). To comprehensively identify relevant studies, a systematic search was conducted in major electronic databases, including PubMed, Embase, and the Cumulative Index to Nursing and Allied Health Literature (CINAHIL). The search was limited to English-language studies published after 31 December 2000. To determine the prevalence of TGD and assess the impacts, we compared forced vital capacity (FVC) (%), forced expiratory volume in one second (FEV1) (%), partial pressure of oxygen (PaO2) (mmHg), and partial pressure of carbon dioxide (PaCO2) (mmHg) between patients with and without TGD. A total of nine articles were included in this meta-analysis. The sample size of included studies ranged from 50 to 309. The pooled prevalence of TGD in patients with COPD was 45% (95% CI: 25% to 65%). The most common form of TGD was hypothyroidism. The study identified a lack of significant associations between TGD and COPD severity or various characteristics, highlighting the need for future prospective multi-center research, particularly with larger sample sizes to determine the clinical factors and biomarkers affecting the development of thyroid dysfunction in this population.

show abstract

“…Both COPD and depressive disorder are characterized by disturbances in thyroid hormone levels [ 12 , 13 ] affected by iodothyronine deiodinases (DIOs), among other factors.…”

mentioning

confidence: 99%

Comparing chronic obstructive pulmonary disease and depressive disorder in terms of inflammation-related biomarkers

2023

View full text Add to dashboard Cite

IntroductionChronic obstructive pulmonary disease (COPD) is characterized by the presence of depressive symptoms.Material and methodsCytokine and deiodinase iodothyronines (DIOs) levels were evaluated in COPD patients and patients diagnosed with depressive disorder and control individuals. using enzyme-linked immunosorbent assays.ResultsInterleukin 1β (IL-1β), and tumor necrosis factor-a (TNF-a) levels were higher in COPD and depression patients than in control individuals. DIO2 were significantly lower in COPD and recurrent depressive disorder (rDD) patients than in controls.ConclusionsChanges in the levels of IL-1β, TNF-a and DIO2 in COPD patients may explain the presence of depression in COPD patients.

show abstract

Thyroid Gland Disease as a Comorbid Condition in COPD

Cited by 7 publications

References 17 publications

Gender-specific disease trajectories prior to the onset of COPD allow individualized screening and early intervention

Gender-specific disease trajectories prior to the onset of COPD allow individualized screening and early intervention

Prevalence and Impact of Thyroid Dysfunction in Patients With Chronic Pulmonary Obstructive Pulmonary Disorder: A Systematic Review and Meta-Analysis

Comparing chronic obstructive pulmonary disease and depressive disorder in terms of inflammation-related biomarkers

Contact Info

Product

Resources

About