Thyroid gland invasion in total laryngectomy: A systematic review and meta-analysis

Xie, Jiaxuan; Wu, Peiyan; Zhang, Siyi; Lu, Zhongming

doi:10.1016/j.ijsu.2022.106262

Cited by 8 publications

(7 citation statements)

References 29 publications

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“…Authors have proposed that the risk factors for PSR can be predicted by clinicopathological features, supporting previous evidence, such as advanced cancer [3,8,24] and positive surgical margins [45], including invasion of the thyroid gland [64–66]. The preventive measures based on the predicted risk of PSR may be a reasonable approach to improve the prognosis of advanced laryngeal cancer patients.…”

Section: Pre-treatment Tumor Debulking Vs Emergency Tracheostomymentioning

confidence: 56%

“…Additional evidences support that preoperative tracheostomy is more a reflection of tumor size impacting oncologic outcomes of patients with advanced-stage laryngeal SCC, as there was no significant difference in the development of PRS between the group having preoperative tracheostomy and the group without [44,61,62 && ,63]. Authors have proposed that the risk factors for PSR can be predicted by clinicopathological features, supporting previous evidence, such as advanced cancer [3,8,24] and positive surgical margins [45], including invasion of the thyroid gland [64][65][66]. The preventive measures based on the predicted risk of PSR may be a reasonable approach to improve the prognosis of advanced laryngeal cancer patients.…”

Section: Pre-treatment Tumor Debulking Vs Emergency Tracheostomymentioning

confidence: 69%

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Peristomal recurrence following primary total laryngectomy: the enigma of the central compartment neck lymph nodes

Bradley¹

2022

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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Purpose of reviewThe practice of primary total laryngectomy (TL) for advanced laryngo-hypopharyngeal cancer has significantly declined in the developed countries. The treatment options most frequently adopted have changed from open surgery to transoral laser or robotic approaches or nonsurgical (bio-chemo-) radiotherapy. Primary TL remains the treatment of choice in the developing world where healthcare resources are limited, especially for the treatment of cancer. Recent findingsPeristomal recurrence (PSR) is quite a serious complication, with an incidence of 6.6% from the published literature (mainly concerning the developed world), most diagnosed within 2 years, and associated with >80% mortality. The major risk factors include pretreatment tracheostomy, specific primary tumor subsites, positive surgical margins, and presence of nodal metastasis. The treatment options are limited and most success has been observed with surgery, especially when PSR is diagnosed at an early-stage, which is uncommon. Treatment of advanced-stage disease is usually palliative. Reduction and/or prevention of the known risk factors for PSR remain the goal when performing TL. In particular, central compartment (paraand pretracheal) lymph nodes dissection in case of large tumors with extra-laryngeal and/or subglottic extension or pretreatment tracheotomy plays a paramount role in PSR prevention. SummaryResearch is required to conclude the formulation of guidelines for proper dissection of the central compartment (level VI) lymph nodes as indicated either prophylactically or therapeutically during TL for preventing PSR.

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Section: Pre-treatment Tumor Debulking Vs Emergency Tracheostomymentioning

confidence: 56%

Section: Pre-treatment Tumor Debulking Vs Emergency Tracheostomymentioning

confidence: 69%

Peristomal recurrence following primary total laryngectomy: the enigma of the central compartment neck lymph nodes

Bradley¹

2022

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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“…The first two concern the single-center and retrospective design, a limitation however found in almost all the 21st century literature on TL. [8][9][10][11]18,[21][22][23][24][25][26][27][28][29][30][31][32][33][34] The third, and doubtless most important, point concerns to a variety of treatments detailed in the section describing the study population (Table I), with TL performed by 54 different headand-neck surgeons (see Acknowledgments) over a period of 4 decades. However, the local recurrence rate seemed not to vary from decade to decade (Table II), relativizing this bias and suggesting that oncologic results, and notably local recurrence, after TL for endolaryngeal cT3-4 SCC are not operator-dependent.…”

Section: Discussionmentioning

confidence: 99%

Primary Total Laryngectomy for Endolaryngeal cT3‐4M0 Squamous Cell Carcinoma: A STROBE Analysis

Laccourreye,

Garcia,

Haroun

et al. 2023

The Laryngoscope

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ObjectivesTo document 10‐year oncologic outcome of primary total laryngectomy (TL) for patients with cT3‐4M0 endolaryngeal squamous cell carcinoma (SCC).Study DesignObservational inception cohort of 531 patients with isolated untreated endolaryngeal cT3‐4M0 SCC review over 40 years using STROBE guideline. 94% of patients were followed until death or for a minimum of 10 years.SettingAcademic tertiary referral care center.MethodsAll patients underwent primary TL. Prior tracheotomy, induction chemotherapy, thyroid gland resection, level II‐IV neck dissection, level VI dissection, and postoperative radiation therapy were associated in 6%, 40%, 43%, 89%, 47%, and 74% of cases, respectively: The main objective was to determine the 10‐year actuarial local control estimate. Accessory objectives comprised screening for clinical variables increasing the risk of local recurrence, and analysis of long‐term oncologic consequences of local recurrence.ResultsThe 10‐year actuarial local control estimate was 89.7%. Local recurrence was salvaged in 11% of cases, resulting in 92% overall local control. On multivariate analysis, none of the study variables correlated with local recurrence. Local recurrence resulted in significantly reduced nodal control, distant metastasis control, and survival. Postoperative complications, persistent index SCC, intercurrent disease, and metachronous second primary cancer accounted for respectively 3%, 37%, 33%, and 28% of the 334 deaths noted during the 10 years following TL.ConclusionThe present study underscored the long‐term oncologic efficacy of primary TL, the dangers of local recurrence, the key role of local control for survival, and the importance of a long‐term oncologic watch policy.Level of Evidence3 Laryngoscope, 2023

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“…If a person's body lacks iodine, hypothyroidism occurs. This disease causes disturbances in water-salt balance and the synthesis of glycosaminoglycans, which affects many body functions [3].…”

Section: Introductionmentioning

confidence: 99%

Compensation for iodine deficiency conditions with drugs based on duckweed substrate

Sadulaev,

Usmanova,

Tataev

et al. 2023

BIO Web Conf.

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Currently, one of the important problems for the entire population of Russia is the problem of iodine deficiency. This pathology is of significant relevance for residents of the North Caucasus. The growth of the goiter epidemic was provoked by the abolition of iodine prophylaxis from salt iodization in the 70s of the 20th century. In order to avoid an increase in morbidity, they began to develop and introduce not only iodine-containing preparations of chemical origin, but also medicines developed from iodine-containing plants acquired particular relevance. Iodine found in plants is well absorbed by the human body, as it is close to it in biological structure. The most common and generally accepted medicinal plants for the treatment of iodine deficiency conditions are white cinquefoil, sugar kelp and bladderwrack. These plants have a high content of natural iodine, but at the same time, the problem is a significant limitation of raw materials. That is why the search for new plant substrates with a high iodine content and the possibility of restoring iodine deficiency states is so important.

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Thyroid gland invasion in total laryngectomy: A systematic review and meta-analysis

Cited by 8 publications

References 29 publications

Peristomal recurrence following primary total laryngectomy: the enigma of the central compartment neck lymph nodes

Peristomal recurrence following primary total laryngectomy: the enigma of the central compartment neck lymph nodes

Primary Total Laryngectomy for Endolaryngeal cT3‐4M0 Squamous Cell Carcinoma: A STROBE Analysis

Compensation for iodine deficiency conditions with drugs based on duckweed substrate

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