Thyroid gland

Rosaí, Juan; Tallini, Giovanni

doi:10.1016/b978-0-323-06969-4.00015-5

Cited by 131 publications

(177 citation statements)

References 941 publications

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“…Differential diagnosis between FTA and FTC is based on presence of capsular or vascular invasion in carcinoma (Rosai, 2011;Bryson et al, 2008) which cannot be evaluated in material obtained from thyroid fine needle aspiration biopsy (Goldstein et al, 2002). Suspicious nodules must therefore be surgically removed in subtotal or total thyroidectomy.…”

Section: Discussionmentioning

confidence: 99%

“…Follicular thyroid adenoma (FTA), a benign encapsulated tumor with evidence of follicular cell differentiation, is the most common thyroid neoplasm (Rosai, 2011). True follicular thyroid carcinoma (FTC) (not including follicular variant of papillary carcinoma) is the malignant thyroid tumor exhibiting evidence of follicular cell differentiation (Rosai, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…One of the most challenging tasks in pathologic evaluation of thyroid lesions, is the differentiation between FTC and FTA. Diagnosis of FTC is dependent on the presence of capsular or vascular invasion (Rosai, 2011;Bryson et al, 2008) .Fine needle aspiration biopsy is not capable to discriminate between FTA and FTC based on the mentioned criteria (Goldstein et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

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Expression of Matrix Metalloproteinase-2, but not Caspase-3, Facilitates Distinction between Benign and Malignant Thyroid Follicular Neoplasms

Sanii¹,

Saffar²,

Tabriz³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Expression of Matrix Metalloproteinase-2, but not Caspase-3, Facilitates Distinction between Benign and Malignant Thyroid Follicular Neoplasms

Sanii¹,

Saffar²,

Tabriz³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Type IV: originate from the pharyngeal mucosa, deeply compared to the palatine tonsils and often can reach the base of the skull [12]. The anomalies of the third and fourth branchial cleft are rare and they are localized at the lower third of the neck [13]. The second branchial cleft cysts are often located between the first and second third of the front surface of the sternocleidomastoid muscle.…”

Section: Discussionmentioning

confidence: 99%

Cysts of the Second Branchial Cleft: Case Report and Surgical Notes

Ciuni¹,

Figuera²,

Spataro³

et al. 2012

J Thyroid Disord Ther

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“…MTCs invade regional lymph nodes and spread hematogenously to distant organs, particularly lungs, liver and bones, which are the major cause of death [2]. Machens and Dralle analyzed 715 cases of MTC and found that 10%, 8% and 5% were diagnosed with lung, liver and bone metastasis, respectively [3].…”

Section: Introductionmentioning

confidence: 99%

Tumor-Associated Lymphatic and Venous Vessels in Medullary Thyroid Carcinomas

Tomita

2015

OJPathology

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Objective: Medullary thyroid carcinomas (MTCs) invade local lymph node through lymphatic vessels and metastasize to distant organs hematogenously and account for a significant mortality. There are possibly increased lymphatic and venous vessels, through which the tumor spreads to lymph nodes and distant organs. Materials and Methods: By immunocytochemical staining for lymphatic and venous vessels, MTC lesions with adjacent normal thyroid and both normal and metastatic lymph nodes were studied for the peritumoral lymphatic and venous vessels, which were morphometrically compared with those of normal thyroid and lymph nodes. Sixteen cases of MTC cases with adjacent thyroid tissues and attached lymph nodes were immunocytochemically stained for lymphatic vessels using lymphatic vessel hyaluronan receptor (LYVE-1) and venous vessels for factor VIII (F-8). The immunostained sections of MTC lesions and metastatic lymph nodes were morphometrically compared for the number and sizes of the vessels with those of normal thyroid tissues and lymph nodes. Results: Significantly increased lymphatic vessels and markedly increased blood vessels were identified in many MTC cases at the peritumoral tissues and metastatic lymph nodes whereas a few lymphatic vessels and no venous vessels were identified in midst of MTCs. The irregular peritumoral lymphatic vessels resembled that of immature lymphatic vessels observed in papillary thyroid carcinomas and increased irregularly, entrapped venous vessels in peritumoral tissues resembled those observed in follicular thyroid carcinomas. Conclusion: The significantly increased lymphatic vessels and markedly increased venous vessels in the peritumoral thyroid tissue support a propensity of MTCs for providing an easy access of tumor cells to both lymphatic spread to the regional lymph nodes and venous spread to distant organs with further tumor spread through metastatic lymph nodes by moderately increased lymphatic and venous vessels.

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Thyroid gland

Cited by 131 publications

References 941 publications

Expression of Matrix Metalloproteinase-2, but not Caspase-3, Facilitates Distinction between Benign and Malignant Thyroid Follicular Neoplasms

Expression of Matrix Metalloproteinase-2, but not Caspase-3, Facilitates Distinction between Benign and Malignant Thyroid Follicular Neoplasms

Cysts of the Second Branchial Cleft: Case Report and Surgical Notes

Tumor-Associated Lymphatic and Venous Vessels in Medullary Thyroid Carcinomas

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