Thyroid hormonal status among children with obesity

Ghergherehchi, Robabeh; Hazhir, Nazanin

doi:10.1177/2042018815571892

Cited by 41 publications

(46 citation statements)

References 29 publications

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“…A recently published study by Ghergherehchi and Hazhir [61] also concludes that TSH levels were significantly higher in obese children compared with the control group (14.7% vs. 6.8%), but in contrast with the earlier mentioned studies, they found that total T4 was also significantly higher in children with obesity (9.5% vs. 3.8% in controls). Among children with obesity…”

Section: Thyroid Function In Overweight and Obese Childrenmentioning

confidence: 82%

“…The authors also found a significantly positive correlation between TSH and T4 level and BMI z-score, but the correlations between fT3 and fT4 and BMI z-score were not significant [61].…”

Section: Prace Poglądowementioning

confidence: 89%

“…Niedawno opublikowane badanie Ghergherehchi i Hazhir [61] także potwierdziło istotnie wyższe stężenia TSH u dzieci otyłych w porównaniu z grupą kontrolną (14,7% vs. 6,8%), ale w przeciwieństwie do wspomnianych wcześniej badań, autorzy stwierdzili także istotnie wyższe stężenie T4 w grupie dzieci otyłych w porów-naniu z grupą kontrolną (9,5% vs. 3,8%). Wśród dzieci otyłych z podwyższonym stężeniem TSH, jedynie u 10,7% stwierdzono obecność przeciwciał przeciwtarczycowych.…”

Section: Przyczyny Zaburzeń Czynności Tarczycy W Otyłościunclassified

“…Wśród dzieci otyłych z podwyższonym stężeniem TSH, jedynie u 10,7% stwierdzono obecność przeciwciał przeciwtarczycowych. Autorzy stwierdzili także istotną dodatnią korelację pomiędzy stężeniami TSH i całkowitą T4 a BMI Z-score, jednocześnie stwierdzając, że korelacja pomiędzy fT3 i fT4 a BMI Z-score była nieistotna [61].…”

Section: Przyczyny Zaburzeń Czynności Tarczycy W Otyłościunclassified

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Zaburzenia funkcji tarczycy u dzieci z otyłością i nadwagą

Witkowska–Sędek

Kucharská

Rumińska

et al. 2017

Endokrynologia Polska

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Obesity and thyroid function are closely related. Thyroid hormones are involved in the regulation of metabolism, thermogenesis, food intake, and fat oxidation. In obese children the most frequent hormonal abnormalities are slight hyperthyrotropinaemia and moderate increases in total T3 and/or fT3 concentrations. Those abnormalities are usually considered a cause of obesity, but according to recent studies, they should actually be considered an adaptation process aimed at increasing resting energy expenditure and total energy expenditure. Those abnormalities do not require any treatment and normalise after substantial weight loss. The mechanisms of those changes are dependent on leptin, thyroid hormone resistance, and mitochondrial dysfunction. The present paper describes the abovementioned mechanisms based on the latest research. We also present a review of some recent original studies evaluating thyroid function in overweight and obese children, including thyroid ultrasound. A thyroid ultrasound scan in obese children frequently shows increased thyroid volume, which correlates with moderately increased TSH levels and a hypoechoic pattern typical of autoimmune thyroiditis, but without antithyroid autoantibodies. Alterations of thyroid function in overweight and obese patients cause an increase in energy expenditure, which facilitates weight loss and prevents further weight gain. Therefore, normalisation of TSH and fT3 after weight loss could explain difficulties in maintaining reduced weight. (Endokrynol Pol 2017; 68 (1): 54-60)

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Section: Thyroid Function In Overweight and Obese Childrenmentioning

confidence: 82%

“…The authors also found a significantly positive correlation between TSH and T4 level and BMI z-score, but the correlations between fT3 and fT4 and BMI z-score were not significant [61].…”

Section: Prace Poglądowementioning

confidence: 89%

Section: Przyczyny Zaburzeń Czynności Tarczycy W Otyłościunclassified

See 2 more Smart Citations

Zaburzenia funkcji tarczycy u dzieci z otyłością i nadwagą

Witkowska–Sędek

Kucharská

Rumińska

et al. 2017

Endokrynologia Polska

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“…TSH serum levels correlate positively with BMI in adults as well as in children, while SH is more frequent in obese subjects compared to non-obese subjects [15,16]. In obese subjects, TSH values consistent with mild SH may revert to normal after weight loss [17,18].…”

Section: General Medical Conditionsmentioning

confidence: 90%

Subclinical hypothyroidism: new trials, old caveats

Lamine¹,

Giorgi²,

Marino³

et al. 2018

Hormones

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The indications for levothyroxine replacement therapy for subclinical hypothyroidism (SH) remain a subject of debate, especially when prescribed for older adults. The results of the recent TRUST trial indicate that levothyroxine does not improve clinical symptom scores among elderly patients with SH. While there is much concern regarding the dilemma of introducing or withholding levothyroxine, less attention may be paid to the differential diagnosis of an elevated TSH level, which is the prerequisite for diagnosing SH. Herein, we review these issues facing endocrinologists and internists/generalists either in practice or in training. When a patient presents abnormal thyroid test results compatible with SH, a series of issues need to be addressed before the implementation of replacement therapy is considered: first, an isolated TSH elevation not linked to a primary thyroid pathology should be excluded; second, the persistent nature of the patient's TSH elevation and SH profile should be verified; third, SH symptoms and potential complications relevant for the specific patient should be documented; fourth, expectations from levothyroxine substitution therapy for SH in the specific patient should be clarified. Only then can the decision be made whether levothyroxine substitution should be introduced or not.

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Thyroid Function in Obese Children and Adolescents and Its Association with Anthropometric and Metabolic Parameters

Rumińska

Witkowska–Sędek

Majcher

et al. 2016

Advances in Experimental Medicine and Biology

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Fat accumulation leads to dysfunction of hypothalamic-pituitary-thyroid axis and to changes in thyroid function. A higher serum level of thyroid stimulating hormone (TSH), with normal levels of thyroid hormones, suggesting subclinical hypothyroidism, is often found in obese individuals. The influence on lipid and glucose metabolism of thyroid dysfunction in obese patients remains unclear. This retrospective study encompassed 110 obese children and 38 healthy non-obese children aged 5-18. Anthropometric measurements, including bioelectrical impedance, were taken in all children. Fasting TSH, fT4, glucose, lipid profile, and a glucose tolerance test in case of the obese individuals, were evaluated. The obese children demonstrated a significantly higher mean concentration of TSH compared with their peers with proper body weight: 2.1 ± 1.0 μIU/ml vs. 1.5 ± 0.6 μIU/ml, p = 0.001. The fT4 was not different between the two groups. In the obese children, TSH correlated with body mass index (BMI) and waist circumference after controlling for age and gender. A multivariate regression analysis showed a relationship of TSH with total cholesterol, LDL cholesterol, triglycerides, and non-HDL after adjusting for BMI. None of these relationships were revealed for fT4. The level of TSH correlated with the degree of abdominal obesity. We conclude that the serum TSH concentration, even remaining within the norm, could adversely affect the lipid profile, irrespective of obesity.

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Thyroid hormonal status among children with obesity

Cited by 41 publications

References 29 publications

Zaburzenia funkcji tarczycy u dzieci z otyłością i nadwagą

Zaburzenia funkcji tarczycy u dzieci z otyłością i nadwagą

Subclinical hypothyroidism: new trials, old caveats

Thyroid Function in Obese Children and Adolescents and Its Association with Anthropometric and Metabolic Parameters

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