Thyroid hormone as a temporal switch in mouse development

Flamant, Frédéric; Ren, Jing

doi:10.1530/etj-22-0225

Cited by 6 publications

(1 citation statement)

References 93 publications

(192 reference statements)

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“…GABAergic neurons, and notably PV-expressing neurons, are a main target of TH signaling during brain development. Although the precise instrumental role of TH in these neurons remains elusive, a widely accepted working hypothesis considers that TH promotes the transition from the embryonic to adult pattern of gene expression in the brain ( 94 , 104 ). For example, TH is involved in triggering the loss of axon regenerative capacity in Purkinje cells ( 99 ), such loss of axon regenerative capacity being a hallmark of brain maturation in rodents ( 105 ).…”

Section: Concluding Considerationsmentioning

confidence: 99%

Thyroid hormone action during GABAergic neuron maturation: The quest for mechanisms

Richard,

Ren,

Flamant

2023

Front. Endocrinol.

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Thyroid hormone (TH) signaling plays a major role in mammalian brain development. Data obtained in the past years in animal models have pinpointed GABAergic neurons as a major target of TH signaling during development, which opens up new perspectives to further investigate the mechanisms by which TH affects brain development. The aim of the present review is to gather the available information about the involvement of TH in the maturation of GABAergic neurons. After giving an overview of the kinds of neurological disorders that may arise from disruption of TH signaling during brain development in humans, we will take a historical perspective to show how rodent models of hypothyroidism have gradually pointed to GABAergic neurons as a main target of TH signaling during brain development. The third part of this review underscores the challenges that are encountered when conducting gene expression studies to investigate the molecular mechanisms that are at play downstream of TH receptors during brain development. Unravelling the mechanisms of action of TH in the developing brain should help make progress in the prevention and treatment of several neurological disorders, including autism and epilepsy.

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