Thyroid Hormone Binding Inhibitor (THBI) Mainly Associated with Serum Oleic Acid Concentration

Herrmann, Jörg; Alasso, G.; Beyer, Mathias; Heinen, E.; Römisch, Jürgen; Weyer, Peter J.

doi:10.1055/s-2007-1013565

Cited by 17 publications

(5 citation statements)

References 1 publication

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“…Concerning T4, our data are qualitatively in agreement with previous reports (Chopra et al 1984;Hermann et al 1985;Stock¬ igt Lim 1985), whereas it has not previously been demonstrated that FFA also are able to displace T3 and rT3 from their serum binding proteins.…”

Section: Discussionsupporting

confidence: 93%

“…It seemed that the potency increased with increasing chain length of the FFA, whereas the number of double bonds apparently was without any significance. A similar increase in inhibitory potency (oleic acid, linoleic acid, and arachidonic acid) was found by Hermann et al (1985). However, they concluded that this was due to a decreasing number of double bonds not taking different chain length into account.…”

Section: Discussionsupporting

confidence: 56%

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The influence of free fatty acids on the free fraction of thyroid hormones in serum as estimated by ultrafiltration

Bregengård

Kirkegaard

Faber

et al. 1987

Acta Endocrinologica

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Thyroid hormones are displaced from their binding proteins in serum during nonthyroidal somatic illness, and FFA have been claimed to contribute. It seems mandatory to evaluate this effect using techniques for the measurements of serum free thyroid hormones in which serum remains undiluted. We measured the effect of 7 common human FFA on the free fraction of T4, T3 and rT3 in serum from healthy subjects using an ultrafiltration technique by which serum is diluted only minimally. In addition we measured the effect of oleic acid on the free fractions of the iodothyronines in pooled serum from healthy subjects and in pooled serum from patients with nonthyroidal illness. All FFA tested were able to displace both T4, T3 and rT3, but to a varying degree, arachidonic and linoleic acid being the most potent ones. A 20% increase in the free fractions of T4, T3 and rT3, respectively, was obtained by adding between 1.7\p=n-\3.3mmol/l, 1.3\p=n-\4.6 mmol/l and 1.0\p=n-\2.4mmol/l of the different FFA. A serum pool obtained from patients with nonthyroidal somatic illness was more sensitive to oleic acid than a serum pool obtained from healthy subjects, since 2\p=n-\3 times less oleic acid was necessary to induce a 20% increase in the free fractions of thyroid hormones. It is concluded that FFA are able to displace both T4, T3 and rT3 from their serum binding proteins in healthy subjects as well as in patients with nonthyroidal illness. However, serum from patients with nonthyroidal illness was more sensitive to the displacing activity of oleic acid than serum from healthy subjects. This was possibly due to reduced affinity of the serum binding proteins to thyroid hormones, and it could be argued that a factor different from FFA seemed responsible.It is well known that patients suffering from nonthyroidal somatic illness (NTI) often have reduced serum total T4 and T3 concentrations, whereas the serum free non-protein bound frac¬ tions of the iodothyronines T4, T3 and rT3 are increased. This seems not totally explained by the concomitant reduction in the concentrations of the thyroid hormone binding proteins in serum (thyroxine binding globulin (TBG), thyroxine binding prealbumin (TBPA) and albumin), since the reduction in the concentration of the binding proteins is less pronounced than the increase in the free fractions of thyroid hormones (FFT)

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 56%

The influence of free fatty acids on the free fraction of thyroid hormones in serum as estimated by ultrafiltration

Bregengård

Kirkegaard

Faber

et al. 1987

Acta Endocrinologica

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“…THBI activity was measured by the method of Herrmann et al 30 Briefly, after extraction of the THBI from the serum by ether, solid phase TBG antibody, labeled T4, and T4‐free serum were added. Both THBI positive sera and merthiolate inhibited T4 binding in a competitive manner; thus THBI activity was calculated in μg merthiolate/μL units.…”

Section: Methodsmentioning

confidence: 99%

Factors Affecting the Serum Free Thyroxine Levels in Hospitalized Chronic Geriatric Patients

Szabolcs¹,

Ploenes

Beyer

et al. 1993

J American Geriatrics Society

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“…T he nature of IEC and THBI has not been completely clarified, but it has been proposed that FFA was the most possible candidate for both IEC and THBI [2,5]. The present study showed a significant correlations among FFA, IEC and THBI and this result indicates that FFA might act as both IEC and THBI at least in vitro.…”

Section: Discussionmentioning

confidence: 48%

Plasma Free Fatty Acids, Inhibitor of Extrathyroidal Conversion of T4 to T3 and Thyroid Hormone Binding Inhibitor in Patients with Various Nonthyroidal Illnesses.

et al. 1992

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Thyroid Hormone Binding Inhibitor (THBI) Mainly Associated with Serum Oleic Acid Concentration

Cited by 17 publications

References 1 publication

The influence of free fatty acids on the free fraction of thyroid hormones in serum as estimated by ultrafiltration

The influence of free fatty acids on the free fraction of thyroid hormones in serum as estimated by ultrafiltration

Factors Affecting the Serum Free Thyroxine Levels in Hospitalized Chronic Geriatric Patients

Plasma Free Fatty Acids, Inhibitor of Extrathyroidal Conversion of T4 to T3 and Thyroid Hormone Binding Inhibitor in Patients with Various Nonthyroidal Illnesses.

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