Thyroid Hormone Correlates of Sensation Seeking and Anxiety in Healthy Human Females

Balada, Ferran; Torrubia, Rafael; Arqué, Josep M.

doi:10.1159/000118839

Cited by 14 publications

(8 citation statements)

References 16 publications

(23 reference statements)

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“…Sensation-seeking levels are high in children of alcoholics, who are at increased genetic risk for drug abuse (Loukas et al , 2001). High and low sensation seekers exhibit differences in physiological responses to novel stimuli (Neary and Zuckerman, 1976; Netter et al , 1996), and differences in hormone and enzyme levels and neuro-transmitter system function have been reported as a function of sensation-seeking status (Schooler et al , 1978; Balada et al , 1992; Netter et al , 1996). Although evidence is mixed, studies suggest that variation in dopamine receptor genes may also be linked to individual differences in sensation-seeking status (Ebstein et al , 1996; Ekelund et al , 1999; Suhara et al , 2001).…”

Section: Introductionmentioning

confidence: 99%

Performance and subjective effects of diazepam and d-amphetamine in high and low sensation seekers

Kelly¹,

Delzer²,

Martin³

et al. 2009

Behavioural Pharmacology

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Although sensation-seeking status is associated with age of initiation and amount of drug use among adolescents, and sensitivity to the behavioral and reinforcing effects of drugs among young adults, it is unclear whether sensation-seeking status among adolescents is predictive of sensitivity to the pharmacological effects of drugs (i.e. abuse potential) as adults. This study examined the acute behavioral effects of oral diazepam and d-amphetamine in young adults, ages 18–21 years, who had consistently scored in the highest or lowest third of their grade-based cohort on a modified Sensation Seeking Scale that was completed annually between ages 10 and 14 years. Healthy participants completed 16 7.5-h test days, with test days separated by a minimum of 48 h. Each day, assessments consisting of computer task performance, verbal report of drug effects, and cardiovascular measures were completed 0, 50, 110, 170, 230, and 290 min after drug administration. Placebo and three active doses of diazepam and d-amphetamine (2.5, 5.0 and 10.0 mg/70 kg) were tested under double-blind conditions according to a randomized-block design. Typical stimulant and sedative effects were obtained with d-amphetamine and diazepam, respectively. Drug effects varied as a function of sensation-seeking status, with magnitude of effects on cardiovascular function, task performance, and report of positive drug effects being greater among high sensation seekers, and report of negative drug effects being greater among low sensation seekers. Adolescents who report high levels of sensation seeking on a consistent basis are more sensitive to pharmacological effects of stimulant and sedative drugs that are associated with abuse potential as young adults.

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Section: Introductionmentioning

confidence: 99%

Performance and subjective effects of diazepam and d-amphetamine in high and low sensation seekers

Kelly¹,

Delzer²,

Martin³

et al. 2009

Behavioural Pharmacology

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“…Plasma and urinary concentrations of beta-endorphin, cortisol (Cort), 17-beta-estradiol, thyrotropin and thyroxine, all hormones whose secretion is modulated by NE [25], correlate negatively with NS and SS scores, even though this has not always been consistent [18,24,[26][27][28]. The correlation between levels of androgens in general, testosterone (T) in particular and SS activity has been reported to be nonconsistent [29][30][31], while a U-shaped relationship has been observed for follicle-stimulating hormone levels [26].…”

Section: Introductionmentioning

confidence: 99%

Neurotransmitters, Neuroendocrine Correlates of Sensation-Seeking Temperament in Normal Humans

Gerra¹,

Avanzini

Zaimovic³

et al. 1999

Neuropsychobiology

103

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Correlations between sensation-seeking (SS) personality dimension and plasma concentrations of norepinephrine (NE), epinephrine, and NE-dependent testosterone (T), cortisol and prolactin (PRL) were studied in 74 physically and psychologically healthy male volunteers, in order to see whether or not the noradrenergic system is involved in the modulation of this personality trait. Novelty-seeking scores by the Temperament and Character Inventory and SS scores on a Visual Analog Scale were positively correlated with plasma NE, T and PRL levels, suggesting that NE and the downstream cascade of NE-dependent hormones, together with other monoaminergic changes, might be responsible for the development and the degree of this temperamental character.

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“…State Anxi ety Scale was included in order to detect anxiogenic effects produced by experimental situations. Subjects and procedures of the present study were the same as those in the study by Balada et al [22] on thyroid hormone corre lates of sensation seeking and anxiety.…”

Section: Introductionmentioning

confidence: 99%

Gonadal Hormone Correlates of Sensation Seeking and Anxiety in Healthy Human Females

Balada

Torrubia²,

Arqué³

1993

Neuropsychobiology

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The present study focused on exploring the relationship between a number of personality measures (Sensation Seeking Scale, SSS; State-Trait Anxiety Inventory, STAI; and Susceptibility to Punishment Scale, SP) and some parameters of the pituitary-gonadal axis (FSH, LH and 17β-estradiol). The study was carried out with a group of 37 female volunteers. The subjects were physically and mentally fit. None of them had a personal history of psychiatric or endocrine illness. All subjects were studied at the beginning of the follicular phase. The most relevant results showed an ‘inverted U shape’ relationship between sensation seeking and plasma FSH levels. Lower Thrill and Adventure Seeking (TAS) scores were also found in subjects with higher levels of 17β-estradiol.

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Thyroid Hormone Correlates of Sensation Seeking and Anxiety in Healthy Human Females

Cited by 14 publications

References 16 publications

Performance and subjective effects of diazepam and d-amphetamine in high and low sensation seekers

Performance and subjective effects of diazepam and d-amphetamine in high and low sensation seekers

Neurotransmitters, Neuroendocrine Correlates of Sensation-Seeking Temperament in Normal Humans

Gonadal Hormone Correlates of Sensation Seeking and Anxiety in Healthy Human Females

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