Thyroid hormone levels are associated with metabolic components: a cross-sectional study

Abstract

Aim To analyze the association of thyroid function and hormone levels with metabolic syndrome (MetS) and its components. Methods This cross-sectional population-based study involved 2183 Croatian individuals with no history of thyroid disease, hypertension, diabetes, and hyperlipidemia. MetS was diagnosed according to the National Cholesterol Education Program’s Adult Treatment Panel III criteria. Results We found no association between thyroid function groups and the prevalence of MetS and its components. Clinically hypothyroid participants showed significantly higher triceps skinfold measurements than subclinically hypothyroid and euthyroid participants. Furthermore, clinically hypothyroid participants had higher abdominal skinfold thickness than subclinically hypothyroid participants. Otherwise, suprailiac and abdominal skinfold measurements were higher in the subclinically and clinically hyperthyroid group of participants compared with euthyroid and subclinically hypothyroid participants. A strong positive association of thyroid-stimulating hormone (TSH) and strong negative association of free triiodothyronine (fT3) and free thyroxine (fT4) levels with HOMA-IR and cholesterol levels were found. Furthermore, the fT4 level also showed a strong negative association with HDL and triceps skinfold thickness. Conclusions This study supports the standing that TSH, fT3, and fT4 levels are important variables to determine the association of thyroid function with MetS.

Exploring associations of anthropometric parameters and serum triglycerides with serum thyroid hormones in young women

“…The absence of significant differences in TSH concentrations in subsequent BMI ranges in healthy young women does not support the common opinion of a direct association between hypothyroidism and obesity or between hyperthyroidism and weight loss 3 . However, the results can demonstrate local involvement of fT3 and fT3/fT4 ratio in the regulation of body weight and confirm another opinion that changes in the serum concentrations of these hormones may be a consequence rather than the cause of changes in the body weight 10 , 35 . Free triodothyronine (fT3) is the active form, converted from free thyroxine (fT4) in peripheral tissues, and the degree of conversion is reflected in the fT3/fT4 ratio.…”

The Impact of Subclinical Hypothyroidism on Lipid Profile in Jeddah

“…A recent study found a signi cant positive association between TSH and Homeostatic Model Assessment of insulin resistance [22]. On the other hand, a recent systematic review found no association between subclinical hypothyroidism and incident diabetes [23]. It should be noted that in spite of not reaching a diabetic level, HbA1c was signi cantly higher among patients with subclinical hypothyroidism in our sample.…”