Thyroid hormone receptors and ligands, tissue distribution and sexual behavior

Carosa, Eleonora; Lenzi, Andrea; Jannini, Emmanuele A.

doi:10.1016/j.mce.2017.11.006

Cited by 36 publications

(15 citation statements)

References 141 publications

(185 reference statements)

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“…In addition, several studies showed at least partial resolution of sexual dysfunction symptoms after treatment of thyroid disease, which is compatible with research confirming the presence of thyroid hormone receptors in the male and female genitalia. 3 When treating patients with sexual dysfunction, physicians should consider endocrine causes such as hyper and hypothyroidism. 48 However, more research is needed to fully understand the relationship between thyroid and sexual dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…However, recent studies have identified the presence of thyroid hormone receptors in both the male and female genitalia including the testis, corpora cavernosa, ovary, and vagina. 3 Sexual dysfunction is composed of a constellation of often overlapping disorders and symptoms 4 . The International Index of Erectile Function (IIEF) was developed in 1997, and assesses five domains of sexual function-erectile function, orgasmic function, sexual desire, intercourse satisfaction, and overall satisfaction.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Thyroid Hormone Derangements on Sexual Function in Men and Women

Bates

Kohn

Pastuszak

2020

Sexual Medicine Reviews

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Introduction: Sexual dysfunction affects many people, with 33-60% of women reporting sexual dysfunction and 8-52% of men with erectile dysfunction (ED) or premature ejaculation (PE). In an effort to determine the constellation of factors responsible for sexual dysfunction, the effect of thyroid hormone derangements has been of recent interest. Aim: To investigate the associations between thyroid hormones and sexual dysfunction in women and men. Methods: Review of the literature examining effects of hypo-and hyperthyroidism on sexual function. Main Outcome Measures: Summary of effects of thyroid dysfunction on domains of sexual functioning. Results: Most studies demonstrate that hypothyroid and hyperthyroid men have increased rates of sexual dysfunction, including erectile dysfunction (ED) in hypothyroid men. However, studies vary on the strength of correlation between hormonal derangement and level of sexual dysfunction. In both hyper-and hypothyroid men, treatment of thyroid disorder at least partially reverses sexual dysfunction. In contrast, the current literature provides no consensus on the effect of hypothyroidism, hyperthyroidism, or Hashimoto's thyroiditis on female sexual function. In studies that observed increased rates of sexual dysfunction in women with thyroid disorders, correction of the thyroid derangement resulted in resolution of some sexual dysfunction. Studies are also conflicted on whether there is a relationship between degree of sexual dysfunction and degree of hormone derangement in women. However, prior work has demonstrated a relationship between thyroid autoantibodies and sexual dysfunction in women.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Thyroid Hormone Derangements on Sexual Function in Men and Women

Bates

Kohn

Pastuszak

2020

Sexual Medicine Reviews

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“…One component of the Wnt signaling pathway, TCF7L1, controlled pluripotent stem cell (such as primordial germ cell) self-renewal and lineage differentiation [40]. Similarly, THRB was a receptor for the thyroid hormone TH, and TH involved in controlling the proliferation and differentiation of Sertoli cells and Leydig cells during testicular development in mammals [41]. As genes often function together, synergistic expression changes of distinct genes might be phenotypically relevant [24,27].…”

Section: Discussionmentioning

confidence: 99%

Identification and characterization of male reproduction-related genes in pig (Sus scrofa) using transcriptome analysis

et al. 2020

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Background: The systematic interrogation of reproduction-related genes was key to gain a comprehensive understanding of the molecular mechanisms underlying male reproductive traits in mammals. Here, based on the data collected from the NCBI SRA database, this study first revealed the genes involved in porcine male reproduction as well their uncharacterized transcriptional characteristics. Results: Results showed that the transcription of porcine genome was more widespread in testis than in other organs (the same for other mammals) and that testis had more tissue-specific genes (1210) than other organs. GO and GSEA analyses suggested that the identified test is-specific genes (TSGs) were associated with male reproduction. Subsequently, the transcriptional characteristics of porcine TSGs, which were conserved across different mammals, were uncovered. Data showed that 195 porcine TSGs shared similar expression patterns with other mammals (cattle, sheep, human and mouse), and had relatively higher transcription abundances and tissue specificity than low-conserved TSGs. Additionally, further analysis of the results suggested that alternative splicing, transcription factors binding, and the presence of other functionally similar genes were all involved in the regulation of porcine TSGs transcription. Conclusions: Overall, this analysis revealed an extensive gene set involved in the regulation of porcine male reproduction and their dynamic transcription patterns. Data reported here provide valuable insights for a further improvement of the economic benefits of pigs as well as future treatments for male infertility.

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“…The mechanism of action through which thyroid diseases induce SD is not known: the most reliable hypotheses are related either to the dysfunction of the hypothalamic thyroid axis which alters prolactin levels (25) or to a direct effect related to the levels of circulating thyroid hormones (30). This second hypothesis can be supported on the basis of the presence of thyroid hormone receptors in the genitals (36,37).…”

Section: Hyperthyroidismmentioning

confidence: 99%

MANAGEMENT OF ENDOCRINE DISEASE: Female sexual dysfunction for the endocrinologist

Carosa

Sansone

Jannini

2020

European Journal of Endocrinology

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Sexual function is an important component of either general health and quality of life in both genders. Many studies have focused on the different risk factors for sexual dysfunctions, proving an association with several medical conditions. Endocrine disorders have been often mentioned in the pathogenesis of female and male sexual dysfunctions; however, particularly in women, sexual function is rarely addressed during clinical, in general, and endocrinological, in particular, consultations. As a thorough diagnosis is required in order to provide an adequately tailored treatment, knowing how each endocrine dysfunction can impair sexual health is of the utmost importance, considering the high prevalence of conditions such as disorders of pituitary, thyroid, adrenal, gonads, as well as metabolic disorders. We performed a thorough review of existing literature on the different mechanisms involved in the pathogenesis of female sexual dysfunctions secondary to endocrine disorders in order to provide an up-to-date reference.

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Thyroid hormone receptors and ligands, tissue distribution and sexual behavior

Cited by 36 publications

References 141 publications

Effect of Thyroid Hormone Derangements on Sexual Function in Men and Women

Effect of Thyroid Hormone Derangements on Sexual Function in Men and Women

Identification and characterization of male reproduction-related genes in pig (Sus scrofa) using transcriptome analysis

MANAGEMENT OF ENDOCRINE DISEASE: Female sexual dysfunction for the endocrinologist

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