Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis

Zhang, Ying; Xue, Yuanyuan; Cao, Chunwei; Huang, Jiaojiao; Hong, Qianlong; Hai, Tang; Jia, Qitao; Wang, Xianlong; Qin, Guosong; Yao, Jing; Zheng, Qiantao; Zhang, Rui; Li, Yongshun; Luo, A-Li; Zhang, Nan; Shi, Guizhi; Wang, Yanfang; Ying, Hao; Z, Liu; Wang, Hongmei; Meng, Anming; Zhou, Qi; Wei, Hong; Liu, Feng; Zhao, Jianguo

doi:10.1182/blood-2017-05-783043

Cited by 48 publications

(45 citation statements)

References 49 publications

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“…Irrespective of AVP deficiency, patients with cDI generally have other factors influencing haematopoiesis, for example anterior pituitary deficiency with or without replacement therapy. Although there is evidence that thyroid hormones 18,19 and glucocorticosteroids 20‐22 have an impact on erythropoiesis, we did not find any association of hypothalamic‐pituitary‐thyroid hormone or HPA axis deficiency and altered haemoglobin levels in cDI patients. This is most likely explained by the euthyroid and euadrenal state of our patients under replacement therapy.…”

Section: Discussioncontrasting

confidence: 92%

Low arginine vasopressin levels in patients with diabetes insipidus are not associated with anaemia

Winzeler

Morin

Refardt

et al. 2020

Clinical Endocrinology

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Objective Arginine vasopressin (AVP) is released upon osmotic stimulation or hypovolaemia in order to maintain water balance. A recent study showed a role of AVP in haematopoiesis by stimulating red blood cell precursors, suggesting a higher risk of anaemia in patients with AVP deficiency. The objective was to explore the effect of low AVP levels in patients with central diabetes insipidus (cDI) and primary polydipsia (PP) on haemoglobin and the prevalence of anaemia. Methods A total of 164 patients with either cDI (70, 43%) or PP (94, 57%) and 30 healthy volunteers from two prospective diagnostic studies performed in Switzerland, Germany and Brazil were studied. A standardized clinical and biochemical (eg copeptin, full blood count) assessment was performed. Haemoglobin and haematocrit levels and prevalence of anaemia (defined as haemoglobin values of <120 g/L in women and <130 g/L in men) were analysed. Results Mean copeptin values were 2.63 pmol/L (±1.08) and 3.91 pmol/L (±4.28) in patients with cDI and PP and 24.76 pmol/L (±5.75) in healthy volunteers, P = .02. The prevalence of anaemia was low in all participants with 7.1%, 2.2% and 10% in cDI, PP and in healthy volunteers, P = .15. Mean haemoglobin values were similar in all groups: 139 g/L (±15.85), 140 g/L (±13.16) and 139 g/L (±13.05) in patients with cDI, PP and healthy volunteers, P = .90, as were mean haematocrit values with 41% in all groups (P = .85). Conclusion Chronic low AVP levels in patients with cDI and PP do not affect haemoglobin levels and prevalence of anaemia.

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Section: Discussioncontrasting

confidence: 92%

Low arginine vasopressin levels in patients with diabetes insipidus are not associated with anaemia

Winzeler

Morin

Refardt

et al. 2020

Clinical Endocrinology

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“…Fatigue, one of the most common and debilitating symptoms in MPN patients, is reported in upwards of 93% of MPN patients, and is thought to be the largest contributor to reduced quality of life [2, 7]. Additionally, disease-related psychosocial sequelae, such as depression, are often refractory and undertreated [8, 9].…”

Section: Introductionmentioning

confidence: 99%

Online yoga in myeloproliferative neoplasm patients: results of a randomized pilot trial to inform future research

Huberty

Eckert

Dueck

et al. 2019

BMC Complement Altern Med

114

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Background Myeloproliferative neoplasm (MPN) patients suffer from significant symptoms, inflammation and reduced quality of life. Yoga improves these outcomes in other cancers, but this hasn’t been demonstrated in MPNs. The purpose of this study was to: (1) explore the limited efficacy (does the program show promise of success) of a 12-week online yoga intervention among MPN patients on symptom burden and quality of life and (2) determine feasibility (practicality: to what extent a measure can be carried out) of remotely collecting inflammatory biomarkers. Methods Patients were recruited nationally and randomized to online yoga (60 min/week of yoga) or wait-list control (asked to maintain normal activity). Weekly yoga minutes were collected with Clicky (online web analytics tool) and self-report. Those in online yoga completed a blood draw at baseline and week 12 to assess inflammation (interleukin-6, tumor necrosis factor- alpha [TNF-α]). All participants completed questionnaires assessing depression, anxiety, fatigue, pain, sleep disturbance, sexual function, total symptom burden, global health, and quality of life at baseline, week seven, 12, and 16. Change from baseline at each time point was computed by group and effect sizes were calculated. Pre-post intervention change in inflammation for the yoga group was compared by t-test. Results Sixty-two MPN patients enrolled and 48 completed the intervention (online yoga = 27; control group = 21). Yoga participation averaged 40.8 min/week via Clicky and 56.1 min/week via self-report. Small/moderate effect sizes were generated from the yoga intervention for sleep disturbance (d = − 0.26 to − 0.61), pain intensity (d = − 0.34 to − 0.51), anxiety (d = − 0.27 to − 0.37), and depression (d = − 0.53 to − 0.78). A total of 92.6 and 70.4% of online yoga participants completed the blood draw at baseline and week 12, respectively, and there was a decrease in TNF-α from baseline to week 12 (− 1.3 ± 1.5 pg/ml). Conclusions Online yoga demonstrated small effects on sleep, pain, and anxiety as well as a moderate effect on depression. Remote blood draw procedures are feasible and the effect size of the intervention on TNF-α was large. Future fully powered randomized controlled trials are needed to test for efficacy. Trial registration This trial was retrospectively registered with clinicaltrials.gov (ID: NCT03503838 ) on 4/19/2018.

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“…We have successfully established a systematic three-generation ENU mutagenesis porcine program and screened a large scale of mutants with a broad range of phenotypes that could be potentially developed into models for human diseases (Hai et al, 2017a, 2017b; Zhang et al, 2017). Forward genetic screening is an important method that can be used to establish human disease models and to facilitate studies of gene function (Hrabé de Angelis and Balling, 1998) due to the advantages like high throughput and identification of novel molecular signal pathways without prior hypothesis (de Bruijn et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

A harlequin ichthyosis pig model with a novel ABCA12 mutation can be rescued by acitretin treatment

Wang

Cao

et al. 2019

Journal of Molecular Cell Biology

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Harlequin ichthyosis (HI) is a severe genetic skin disorder and caused by mutation in the ATP-binding cassette A12 (ABCA12) gene. The retinoid administration has dramatically improved long-term survival of HI, but improvements are still needed. However, the ABCA12 null mice failed to respond to retinoid treatment, which impedes the development of novel cure strategies for HI. Here we generated an ethylnitrosourea mutagenic HI pig model (named Z9), which carries a novel deep intronic mutation IVS49-727 A>G in the ABCA12 gene, resulting in abnormal mRNA splicing and truncated protein production. Z9 pigs exhibit significant clinical symptom as human patients with HI. Most importantly, systemic retinoid treatment significantly prolonged the life span of the mutant pigs via improving epidermal maturation, decreasing epidermal apoptosis, and triggering the expression of ABCA6. Taken together, this pig model perfectly resembles the clinical symptom and molecular pathology of patients with HI and will be useful for understanding mechanistic insight and developing therapeutic strategies.

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Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis

Cited by 48 publications

References 49 publications

Low arginine vasopressin levels in patients with diabetes insipidus are not associated with anaemia

Low arginine vasopressin levels in patients with diabetes insipidus are not associated with anaemia

Online yoga in myeloproliferative neoplasm patients: results of a randomized pilot trial to inform future research

A harlequin ichthyosis pig model with a novel ABCA12 mutation can be rescued by acitretin treatment

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