Thyroid hormone resistance and enlargement of the sella turcica during pregnancy

Siristatidis, Charalambos; Mastorakos, George; Vitoratos, N.; Gregoriou, O.; Iakovidou, Helen; Salamalekis, E.; Creatsas, George

doi:10.1007/s00404-002-0455-8

Cited by 7 publications

(3 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a large series of patients reported by Brucker-Davis and cols., we found the first report on the association between thyroid cancer and RTH syndrome (8). More recently, four other cases were described (13)(14)(15)(16). Table 1 summarizes the clinical and molecular characteristics of our case and previously reported ones.…”

Section: Discussionmentioning

confidence: 61%

“…Except for our case, all patients tested for thyroid peroxidase antibody showed to be negative. All reports highlighted the difficulties of managing post-surgical hypothyroidism, and the need for higher than usual doses of levothyroxine (~3 µg/kg) to get near-normal TSH levels (13,14,16). A fascinating observation is that, despite the chronic TSH stimulation characteristic of RTH, disease presentation at diagnosis and follow-up of these patients suggests non-aggressive tumor behavior (13,14,16).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Is there a role for inherited TR βmutation in human carcinogenesis?

Weinert

Ceolin

Romitti

et al. 2012

Arq Bras Endocrinol Metab

View full text Add to dashboard Cite

SUMMARYResistance to thyroid hormone (RTH) is a rare autosomal dominant inherited disorder characterized by end-organ reduced sensitivity to thyroid hormone. This syndrome is caused by mutations of the thyroid hormone receptor (TR) β gene, and its clinical presentation is quite variable. Goiter is reported to be the most common finding. A close association of TRβ mutations with human cancers has become apparent, but the role of TRβ mutants in the carcinogenesis is still undefined. Moreover, higher TSH levels, described in RTH syndrome, are correlated with increased risk of thyroid malignancy, whereas TSH receptor stimulation is likely to be involved in tumor progression. We report here an illustrative case of a 29 year-old patient with RTH caused by a mutation in exon 9 (A317T) of TRβ gene, who presented multicentric papillary thyroid cancer. We review the literature on this uncommon feature, and discuss the potential role of this mutation on human tumorigenesis, as well as the challenges in patient follow-up. Arq Bras Endocrinol Metab. 2012;56(1):67-71 SUMÁRIO A síndrome da resistência aos hormônios tireoidianos (RHT) é caracterizada por redução da sensibilidade aos hormônios da tireoide. A apresentação clínica é variável, sendo a presença de bócio a manifestação mais frequentemente descrita. A associação de mutação no receptor β e neoplasias em humanos vem sendo demonstrada recentemente, porém o mecanismo pelo qual a mutação desse receptor está envolvida na carcinogênese não está completamente definido. Além disso, níveis elevados de TSH sérico, descritos na RHT, estão associados a aumento do risco de câncer de tireoide, e o estímulo do TSH está provavelmente envolvido na patogênese desses carcinomas. Este artigo relata o caso de um homem de 29 anos com RHT, com análise molecular demonstrando mutação no éxon 9, códon 317, e carcinoma papilar de tireoide. Revisamos a literatura dos casos relatados os quais descrevem associação entre RHT e câncer de tireoide e discutimos os desafios do tratamento e seguimento desses pacientes. Arq Bras Endocrinol Metab. 2012;56(1):67-71

show abstract

Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Is there a role for inherited TR βmutation in human carcinogenesis?

Weinert

Ceolin

Romitti

et al. 2012

Arq Bras Endocrinol Metab

View full text Add to dashboard Cite

show abstract

“…RTH has been reported in patients with primary hyperparathyroidism (15). Surprisingly, only about three cases of papillary thyroid carcinoma and RTH have been described in the literature (8)(9)(10).…”

Section: Discussionmentioning

confidence: 97%

Differentiated Thyroid Cancer in Two Patients with Resistance to Thyroid Hormone

Paragliola

Lovicu

Locantore

et al. 2011

Thyroid

View full text Add to dashboard Cite

Patients with thyroid carcinoma and RTH are a unique model of thyroid cancer in which follow-up likely occurs in the setting of constantly elevated serum TSH concentrations. The concern in these patients is that their persistent elevation of serum TSH may have an adverse effect on their thyroid cancer, and management choices in terms of the dose of LT(4) that provides the optimum lowering of serum TSH without toxicity are difficult, particularly in the situation wherein, as was the case with one of our patients, there is cardiac disease.

show abstract