Thyroid hormone status in Ghanaian patients with chronic kidney disease

Aryee, Nii Ayite; Tagoe, Emmanuel Ayitey; Anomah, Victor; Arko-Boham, Benjamin; Adjei, David Nana

doi:10.11604/pamj.2018.29.137.12992

Cited by 9 publications

(12 citation statements)

References 20 publications

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“…In the present study, 25/45 (55.5%) patients were female and 20/45 (20%) were male and the obtained results were in contrast with the study by Petimani and Adake that 77.7% of patients (35/45) were male and 22.2% of them (10/45) were female [ 45 ]. These results were in agreement with the study by Rashead and Aryee et al [ 46 , 47 ]. Low thyroid hormone levels (i.e., triiodothyronine) have been associated with adverse cardiovascular sequela in CKD and kidney failure, but these metrics are confounded by malnutrition, inflammation, and comorbid states and hence may signify nonthyroidal illness (i.e., thyroid functional test derangements associated with underlying ill health in the absence of thyroid pathology).…”

Section: Discussionsupporting

confidence: 94%

Bidirectional Interaction of Thyroid-Kidney Organs in Disease States

Amiri

2020

International Journal of Nephrology

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Purpose. Thyroid hormones play an important role in growth, development, and physiology of the kidney. The kidney plays a key role in the metabolism, degradation, and excretion of thyroid hormones and its metabolites. The aim of this study is to investigate the prevalence of disease states of thyroid-kidney organs and detecting the correlation between thyroid and kidney function abnormalities. Materials and Methods. In this retrospective study, a total of forty-five patients with thyroid and kidney dysfunction were investigated. Clinical features, laboratory data at initial presentation, management, and outcomes were collected. The paper has been written based on searching PubMed and Google Scholar to identify potentially relevant articles or abstracts. Median, percentage, mean ± standard deviation (SD), and the two-tailed t-test were used for statistical analyses. The correlation between variables was assessed by Pearson’s, Spearman’s correlation tests and regression analyses. Results. The mean ± SD of age of study patients was 48.2 ± 22.93 years (ranging from 1 to 90 years). There was no correlation between serum thyroid-stimulating hormone, free thyroxine levels with estimated glomerular filtration rate, and proteinuria. No association between antimicrosomal antibodies with estimated glomerular filtration rate was seen. Cardiovascular disease was the most common complication of overt hypothyroidism in kidney dysfunction patients. Conclusion. The present study showed more prevalence of primary hypothyroidism in comparison with other thyroid dysfunctions in patients with kidney dysfunction. Reduced mean values of thyroid function profiles after treatment suggest that this thyroid disease should be considered and ameliorated with thyroid hormone replacement therapy in patients with kidney disease.

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Section: Discussionsupporting

confidence: 94%

Bidirectional Interaction of Thyroid-Kidney Organs in Disease States

Amiri

2020

International Journal of Nephrology

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“…In chronic renal disease, there is significant reduction in kidney function accompanied by iodine retention, metabolic acidosis and alteration of thyroid function [ 13 ]. There are a number of observational studies that have reported various modifications of thyroid function test profile in chronic kidney disease patients [ 14 , 15 ]. Thyroid dysfunction ensues in chronic kidney disease with a significant decrease in total and free T4, total and free T3 and elevated TSH that is associated with increasing renal impairment and reduced GFR [ 14 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Cystatin C, Vitamin D and Thyroid Function Test Profile in Chronic Kidney Disease Patients

et al. 2021

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Background: The progression of chronic kidney disease (CKD) is concomitant with complications, including thyroid dysfunction, dyslipidemia and cardiovascular diseases. The aim of this study is to determine serum cystatin C levels, and the prevalence of vitamin D deficiency and thyroid dysfunction in CKD patients. Methods: A cross-sectional study was conducted involving 140 CKD patients (stages 1–5) that were referred to a renal clinic. Demographic data was collected and thyroid function tests, serum 25-OH-vitamin D, cystatin C levels, and routine biochemistry tests were determined using cobas 6000 analyzer. Results: 129 (92.1%) of CKD patients had elevated serum cystatin C levels and there was a stepwise increase from stage 1–5. Overt hypothyroidism was present in one patient and nine had subclinical hypothyroidism. There was a stepwise reduction in serum 25-OH-vitamin D levels from stage 2–5, 31 (22.1%) had vitamin D insufficiency and 31 (22.1%) presented with deficiency. Conclusions: 25-OH-vitamin D deficiency and thyroid disorders are exhibited in chronic kidney disease patients and the severity of the former rises with disease progression, as indicated by elevated cystatin C levels. Routine screening and timely intervention is recommended so as to reduce the risk of cardiovascular diseases.

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“…There was 1.7% of primary hyperthyroidism in patients with hyperglycaemia (MH and SH) and none among the good glycaemic controls. A similar study in Ghana by Tagoe et al 26 estimated 10.1% thyroid dysfunction in patients with hyperglycaemia and 5.1% among the good glycaemic controls. In a related study by Rai et al and Udiong et al 5,38 prevalence of thyroid dysfunction was found to be 46.5% among Nigerian diabetic patients.…”

Section: Discussionmentioning

confidence: 73%

Thyroid dysfunction and glycaemic control among Type 2 diabetes mellitus patients in Ghana: A comparative cross‐sectional study

Sakyi,

Ameyaw,

Laing

et al. 2023

Endocrino Diabet & Metabol

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IntroductionThyroid disorders and diabetes mellitus coexist and are prevalent endocrinopathies among adult population. Thyroid dysfunction contributes to metabolic imbalances, increase beta‐cell apoptosis and glucose intolerance. There is paucity of data and contradicting findings on how thyroid dysfunction influence glycaemic control. Therefore, we evaluated thyroid dysfunction and glycaemic control among Type 2 diabetes mellitus (T2DM) patients in Ghana.MethodsA comparative cross‐sectional study was conducted among 192 T2DM patients from Effia Nkwanta Regional Hospital. Three consecutive monthly fasting plasma glucose (FBG) and glycated haemoglobin (HbA1c) were analysed and the results were classified as, moderate hyperglycaemia (MH) (FBG = 6.1–12.0 mmol/L, HbA1c < 7%), severe hyperglycaemia (SH) (FBG ≥ 12.1 mmol/L, HbA1c > 7%) and good glycaemic controls (GC) (FBG = 4.1–6.0 mmol/L, HbA1c < 7%). Thyroid‐stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxine (FT4), body mass index (BMI) and other clinical parameters were measured. Data analysis was done using R language version 4.0.2 and p < .05 was considered statistically significant.ResultsThere were no significant differences in age (years) between patients in the various glycaemic groups (p = .9053). The overall prevalence of thyroid disorders was 7.8% among T2DM patients. The prevalence of thyroid disorders was higher in patients with SH (11.7%) followed by those with MH (7.5%) and then those with GC (5.4%). Serum levels of TSH and FT3/FT4 ratio were significantly lower in T2DM patients with SH compared to those with MH and the GC (p < .0001). However, FT4 was significantly higher in SH patients compared to the good glycaemic controls (p < .01). The first tertiles of TSH [aOR = 10.51, 95% CI (4.04–17.36), p < .0001] and FT3 [aOR = 2.77, 95% CI (1.11–6.92), p = .0290] were significantly and independently associated with increased odds of hyperglycaemia.ConclusionThe prevalence of thyroid dysfunction is high in T2DM and increases with hyperglycaemia. Reduced TSH and T3 may worsen glycaemic control. Periodic monitoring of thyroid function should be incorporated into management guidelines among T2DM patients in Ghana.

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Thyroid hormone status in Ghanaian patients with chronic kidney disease

Cited by 9 publications

References 20 publications

Bidirectional Interaction of Thyroid-Kidney Organs in Disease States

Bidirectional Interaction of Thyroid-Kidney Organs in Disease States

Cystatin C, Vitamin D and Thyroid Function Test Profile in Chronic Kidney Disease Patients

Thyroid dysfunction and glycaemic control among Type 2 diabetes mellitus patients in Ghana: A comparative cross‐sectional study

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