Thyroid hormone therapy of hypothyroidism in pregnancy

Shan, Zhongyan; Wang, Teng

doi:10.1007/s12020-019-02044-2

Cited by 20 publications

(11 citation statements)

References 63 publications

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“…(1,4,(6)(7)(8) If hypothyroidism is diagnosed during pregnancy, LT₄ medication is initiated with the usual dosage ranging between 50 and 100 µg/day (9). However, it is controversial whether subclinical hypothyroidism, diagnosed during pregnancy, should be treated with levothyroxine (1). Untreated overt hypothyroidism is associated with various well-known complications both for the pregnant woman and her unborn child.…”

Section: Introductionmentioning

confidence: 99%

Hypothyroidism and the increased risk of preeclampsia – interpretative factors?

Lintula

Keski‐Nisula

Sahlman

2020

Hypertension in Pregnancy

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Objective: To evaluate the causes behind the association between hypothyroidism and the risk of preeclampsia. Methods: Checking of individual hospital and birth records from 149 levothyroxine users among 2,508 women in the preeclampsia case-control study (2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016). Results: There were significant association between levothyroxine medication and preeclampsia (OR 1.48, 95 th CI 1.06-2.07; p ≤ 0.022). The presence of comorbid diseases was associated with a significantly higher risk for the development of preeclampsia in women using levothyroxine. Conclusion: Levothyroxine use during pregnancy was associated with 1.5-times higher risk for preeclampsia, but it is also linked to the other comorbid risk factors.

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Section: Introductionmentioning

confidence: 99%

Hypothyroidism and the increased risk of preeclampsia – interpretative factors?

Lintula

Keski‐Nisula

Sahlman

2020

Hypertension in Pregnancy

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“…In recent years, many studies have suggested that the incidence of thyroid dysfunction in pregnant women is dramatically high and is related to changes in maternal and fetal physiological hormone metabolism during pregnancy (35,36). Thyroid dysfunction not only leads to pregnancy-induced hypertension, diabetes, anemia, and other diseases in pregnant women, but also affects the development of the fetal nervous system to some extent (37). During pregnancy, timely detection of thyroid dysfunction and coordinated control by appropriate planning are helpful for reducing the occurrence of adverse pregnancy outcomes.…”

Section: Discussionmentioning

confidence: 99%

Systematic review and meta-analysis on the influence of thyroid dysfunction in early pregnancy on pregnancy outcomes under ultrasound guidance

Geng¹,

Chen²,

et al. 2022

Ann Palliat Med

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Background: Thyroid dysfunction during pregnancy has a certain impact on pregnancy outcomes and neonatal growth, but there is no systematic evaluation of the influence of thyroid dysfunction during early pregnancy under ultrasound guidance on pregnancy outcomes.Methods: PubMed, Web of Science, Springer, and Science Direct databases were used to screen clinical studies on the effect of thyroid dysfunction during pregnancy on pregnancy outcomes from January 2010 to June 2021. Meta-analysis of data was conducted using RevMan 5.3 software. Differences of indicators were compared between the normal and abnormal thyroid function groups, including the ratio of primiparas, anemia, intrauterine growth restriction, perinatal fetal death, preterm delivery, fetal distress syndrome, cesarean section, preeclampsia, placental abruption, postpartum hemorrhage, and neonatal complications.Heterogeneity of results was assessed by chi-square test and I 2 test in RevMan5.3.Results: A total of 788,867 pregnant women were included in 13 studies. Cochrane scores were grade B or above, and Jadad scale scores were higher than 3. Anemia [odds ratio (OR) =0.

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“…(1,3,27-28) Aunque los estudios que han evaluado el efecto del tratamiento en el neurodesarrollo de la descendencia no han mostrado beneficios, cabe destacar que estos iniciaron el tratamiento posterior al periodo embrionario. (5,11,21)…”

Section: 1hipotiroidismo Clínicounclassified

“…(2) Sin embargo, estos porcentajes varían según el corte de hormona estimulante de la tiroides (TSH) utilizado para el diagnóstico, edad, región geográfica, ingesta de yodo y etnia materna. (3)(4)(5) Particularmente, la deficiencia de yodo tiene una mayor influencia sobre la prevalencia de hipotiroidismo subclínico en comparación con la de hipotiroidismo clínico. (5) El embarazo es un estado que conduce a un aumento de los requerimientos de la glándula tiroides, lo que explica la aparición de la patología tiroidea durante el periodo gestacional en pacientes con factores predisponentes.…”

Section: Introductionunclassified

Hipotiroidismo Durante El Embarazo

Rodríguez

Figueroa

Vindas

2021

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Resumen Las enfermedades tiroideas están entre los trastornos endocrinos más frecuentemente reportados durante el embarazo, en parte debido a los cambios fisiológicos que ocurren principalmente en el primer trimestre. En pacientes embarazadas, el hipotiroidismo clínico tiene una prevalencia de 0.3-1.9%, mientras que el hipotiroidismo subclínico de 1.5-5%. Estos porcentajes dependen de diferentes variables como la ingesta de yodo. Se ha visto que el hipotiroidismo generalmente representa un riesgo para la unidad materno-fetal, por lo que se debe tener en cuenta el rango de referencia trimestral de TSH según la población para realizar un diagnóstico apropiado. El tratamiento consiste en levotiroxina oral, según las metas establecidas. Además, la captación de aquellas pacientes que presenten factores de riesgo, así como aquellas con diagnóstico previo de hipotiroidismo permite darles el seguimiento adecuado. Por lo anterior, es necesario que los diferentes servicios cuenten con bases de datos a nivel regional o nacional para establecer rangos de referencia trimestrales específicos para la población.

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Thyroid hormone therapy of hypothyroidism in pregnancy

Cited by 20 publications

References 63 publications

Hypothyroidism and the increased risk of preeclampsia – interpretative factors?

Hypothyroidism and the increased risk of preeclampsia – interpretative factors?

Systematic review and meta-analysis on the influence of thyroid dysfunction in early pregnancy on pregnancy outcomes under ultrasound guidance

Hipotiroidismo Durante El Embarazo

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