1992
DOI: 10.1210/endo.130.2.1733724
|View full text |Cite
|
Sign up to set email alerts
|

Thyroid hormones and 5'-deiodinase activity in neonatal undernourished rats.

Abstract: Undernutrition was induced in rats submitted to food restriction from the fetal stage, and malnutrition was continued after birth until 70 days of life. Body weight was decreased to less than 50%. Plasma T4 and T3 and pituitary TSH content were determined between 8-70 days of life. In control rats, plasma T4 and T3 reached a maximum at 14 and 35 days of life, respectively, and TSH pituitary content at 45 days of life. In undernourished rats, after 8 days of life, plasma T4 and T3 and pituitary TSH content were… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
3
0

Year Published

2000
2000
2016
2016

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 9 publications
(3 citation statements)
references
References 15 publications
0
3
0
Order By: Relevance
“…A relevant fact to consider in the thyroid axis regulation in undernutrition and diabetes, is the presence oflow circulating TSH levels along with reduced thyroid hormones (1,13,26,30,34) contrary to what occurs in hypothyroidism. Pituitary TSH levels depends mainly on a balance between the stimulatory action of TRH on TSH synthesis and secretion and the inhibitory role of T3 on TSH secretion and TRH synthesis (4,10).…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…A relevant fact to consider in the thyroid axis regulation in undernutrition and diabetes, is the presence oflow circulating TSH levels along with reduced thyroid hormones (1,13,26,30,34) contrary to what occurs in hypothyroidism. Pituitary TSH levels depends mainly on a balance between the stimulatory action of TRH on TSH synthesis and secretion and the inhibitory role of T3 on TSH secretion and TRH synthesis (4,10).…”
Section: Discussionmentioning
confidence: 99%
“…Among all "euthyroid sick syndromes", undernutrition and diabetes show a common pattern at the cellular level: cell starvation due to the lack of nutrients or to their reduced utilization by the absence of insulin. Both, undernutrition and diabetes, considered as "low T3 syndromes", induce a significant reduction of serum T3 and T4, together with a fall in pituitary and plasma TSH (1,13,26,30,34) as opposed to the usual increase in plasma TSH observed in hypothyroidism. Pituitary a and~TSH and GH mRNA levels are decreased in restricted feeding, fasting and diabetes in rats (29).…”
mentioning
confidence: 99%
See 1 more Smart Citation