Thyroid hormones and atrial natriuretic hormone secretion: study in hyper- and hypothyroid patients

Rolandi, E; Santaniello, B; Bagnasco, Marcello; Cataldi, A.; Garibaldi, Cristina; Franceschini, R.; Barreca, T

doi:10.1530/acta.0.1270023

Cited by 10 publications

(6 citation statements)

References 17 publications

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“…After thyroid replacement these concentrations have increased in some reports (Kohno et al 1987, Zimmerman et al 1987, Woolf & Moult 1988, Rolandi et al 1992, Bernstein et al 1997 but not in others (Weissel et al 1986, Ladenson et al 1987. One of the possible explanations for these discrepancies may lie in the comparability of the groups, since in most studies the mean age of the hypothyroid patients is higher than that of the control group.…”

Section: Discussionmentioning

confidence: 94%

“…In patients with hypothyroidism, plasma ANH concentrations have been reported to be low (Kohno et al 1987, Zimmerman et al 1987, Woolf & Moult 1988, Widecka et al 1990, Barna et al 1994, Ota et al 1994 or normal (Ladenson et al 1987, Rolandi et al 1992. After thyroid replacement these concentrations have increased in some reports (Kohno et al 1987, Zimmerman et al 1987, Woolf & Moult 1988, Rolandi et al 1992, Bernstein et al 1997 but not in others (Weissel et al 1986, Ladenson et al 1987.…”

Section: Discussionmentioning

confidence: 98%

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Water metabolism disturbances at different stages of primary thyroid failure

Villabona¹,

Rosel²,

Navarro³

et al. 2001

Journal of Endocrinology

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The aim of the present study was to study salt and water metabolism in thyroid deficiency.We performed an oral water loading test (OWL) and a hypertonic 5% saline infusion test (HSI) in 16 patients with overt primary hypothyroidism before replacement treatment (PRE group) and after, in eight patients with subclinical hypothyroidism (SUB group) and in 16 normal individuals (CG group).In the PRE group, a lower free water clearance was detected in the OWL (P<0·022), with lower plasma osmolality (OWL: P<0·005; HSI: P<0·001) and arginine vasopressin (AVP) (OWL: P<0·001; HSI: P<0·001) than the CG group, across both tests; they normalized with the replacement treatment. The same plasma abnormalities were detected in the SUB group with the HSI. Although the AVP and thirst thresholds did not differ between the groups, the lag between them was lower in the PRE (4·1 3·2 mOsm/kg) and SUB group (2·6 2·1 mOsm/ kg) than in the CG group (13·3 9·2 mOsm/kg) (P<0·05). There were no differences in atrial natriuretic hormone (ANH), plasma renin activity (PRA) and plasma aldosterone among the groups.These results indicate that plasma hypo-osmolality and low levels of AVP are present in primary hypothyroidism, and indeed are already present in the subclinical phase of the disease. An overlap between the thresholds of thirst and AVP seem to play a role in these abnormalities, but ANH, PRA and plasma aldosterone do not appear to contribute.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 98%

Water metabolism disturbances at different stages of primary thyroid failure

Villabona¹,

Rosel²,

Navarro³

et al. 2001

Journal of Endocrinology

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“…The majority of pertinent studies have shown that ANP levels in patients with untreated hyperthyroidism and hypothyroidism were significantly different from those of normal subjects 18,19,26,[28][29][30][31] and returned to normal after appropriate treatment. However, at least in one study different results were detected 22 .…”

Section: Discussionmentioning

confidence: 99%

“…Furthemore, human studies revealed that plasma ANP levels are significantly higher in hyperthyroid and lower in hypothyroid patients compared to euthyroid controls (17)(18)(19)(20)(21) . ANP levels return to normal following appropriate treatment.…”

Section: Introductionmentioning

confidence: 99%

Normalization of thyroid hormone levels in patients with either hyper- or hypothyroidism results in a profound change of atrial natriuretic peptide (ANP) levels

Koukoulis¹,

Polymeris²,

Tzavara³

et al. 2002

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Atrial Natriuretic Peptide (ANP) is a hormone produced by cardiac atrial myocytes. Thyroid hormones may affect its release. The aim of this study was to analyze the effect of hyper and hypothyroidism on the secretion of ANP and its relationship with the changes of the renin-angiotensinaldosterone system. Plasma ANP concentration as well as plasma renin activity (PRA) and aldosterone (ALDO) were measured in 21 patients with hyperthyroidism, 12 patients with hypothyroidism and 29 normal controls. Moreover, in 5 hyperthyroid and 8 hypothyroid patients hormones measurements were performed at diagnosis and 15, 30, 45 and 60 days after starting the appropriate therapy. Statistical analysis was performed employing the Wilcoxon two sample test to compare the ANP levels in normal and hyper or hypothyroid patients while the pairwise comparisons were evaluated using the Spermans rank correlation. Partial correlation and regression models were used to examine the joint effects of multiple predictors on ANP. ANP levels were significantly higher in hyperthyroid (mean±SEM, 17±1.7pmol/L, p<0.001) and lower in hypothyroid patients (6.18±1.14pmol/L, p<0.01) compared to normals (10.35±0.59pmol/L). In the hyperthyroid patients following treatment with antithyroid drugs plasma ANP levels reached normal values after 15 days and remained stable thereafter. In the hypothyroid patients, ANP levels increased gradually following initiation of treatment with thyroxine, reaching values comparable to controls at day 45. PRA was significantly higher only in hyperthyroid patients compared to controls. ALDO concentrations were not different in all groups studied. No correlation was found between plasma ANP levels and T3, T4, TSH, PRA and ALDO levels in the individual groups, while a positive correlation for T3 (r=0.610, p<0.01), T4 (r=0.653, p<0.01) and pulse rate (r=0.704, p<0.01) and negative correlation with TSH (r=-0.519, p<0.01) was found when all groups were pooled together. In conclusion, our data indicate that thyroid hormones affect positively ANP secretion from cardiac myocytes. This effect may be, at least in part, indirect via hemodynamic alterations.

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“…Human studies have shown that plasma ANP secretion is affected by thyroid hormones, being higher in hyperthyroid patients compared to euthyroid controls [10–12] and returning to normal levels after appropriate treatment [13]. There is a strong positive relationship between circulating thyroid hormones and both atrial and ventricular ANP mRNA contents [14, 15], supporting the hypothesis that ANP synthesis and/or secretion from atrial cardiomyocytes remain under thyroid hormone control.…”

Section: Introductionmentioning

confidence: 99%

Acute Experimental Hyperthyroidism Does Not Affect Basal and Volume-Induced Atrial Natriuretic Peptide Secretion in Healthy Subjects

Giamouzis

Pappas

Simeonidis

et al. 2011

Cardiology Research and Practice

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Background. Excess circulating thyroid hormones are associated with increased cardiac atrial natriuretic peptide (ANP) secretion but the exact mechanisms involved have not been fully elucidated in vivo. Methods. To examine whether thyroid hormone regulation of ANP secretion is the result of a direct action on the myocardium and/or of an indirect action through alterations in the peripheral circulation, plasma ANP levels (baseline and volume expansion-induced) were evaluated in 14 healthy men, before and after triiodothyronine (T3) administration. Results. T3 administration was followed by a significant increase in serum T3 levels and a significant decrease in serum TSH levels, without significantly affecting ANP levels. Systemic vascular resistance, plasma rennin activity (PRA), and aldosterone (ALDO) levels, as well as indices of left atrial function, were not significantly altered, despite a significant increase in cardiac output. Plasma volume expansion, induced by a 1500 ml normal saline (NSal) infusion, both before and after T3 administration, was followed by a significant decrease in PRA and ALDO and a significant increase in plasma ANP levels, without significantly affecting the mean blood pressure (BP) and heart rate (HR) in each study period. The NSal-induced response, measured as the integrated area under the curve corrected for baseline values (-AUC), was not different after T3 administration for ANP, ALDO, PRA, HR, and mean BP. Conclusion. In vivo thyroid hormone-induced myocardial ANP secretion is the result of an indirect action mainly through hemodynamic changes that increase atrial stretch.

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Thyroid hormones and atrial natriuretic hormone secretion: study in hyper- and hypothyroid patients

Cited by 10 publications

References 17 publications

Water metabolism disturbances at different stages of primary thyroid failure

Water metabolism disturbances at different stages of primary thyroid failure

Normalization of thyroid hormone levels in patients with either hyper- or hypothyroidism results in a profound change of atrial natriuretic peptide (ANP) levels

Acute Experimental Hyperthyroidism Does Not Affect Basal and Volume-Induced Atrial Natriuretic Peptide Secretion in Healthy Subjects

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