Thyroid hormones and erythrocyte indices in a cohort of euthyroid older subjects

Schindhelm, Roger K.; Boekel, Edwin ten; Heima, Nathalie E.; Schoor, Natasja M. van; Şimşek, Suat

doi:10.1016/j.ejim.2012.12.004

Cited by 29 publications

(26 citation statements)

References 28 publications

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“…However, the authors did not observe any correlation between TSH and erythrocyte indices. [29] The present study agrees with the reported findings of Bremner et al as there was a significant decrease in erythrocyte indices in the abnormal thyroid group compared to control and there was a significant positive correlation of serum FT4 with the RBC count, hemoglobin concentrations, PCV, and MCH. The present findings support the hypothesis that FT4 plays an important role in the regulation of erythropoiesis.…”

Section: Discussionsupporting

confidence: 82%

“…[30] Thyroid hormones were also shown to regulate the gene expression of transferrin; hence, it has been suggested that the thyroid hormones regulate the iron metabolism. [29][30][31][32] On the other hand, several other studies have demonstrated that iron deficiency could be a risk factor for the development of thyroid abnormalities. A recent experimental study reported that iron deficiency prior to pregnancy in female rats led to maternal hypothyroxinemia during gestation.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence and characteristics of anemia associated with thyroid disorders in non-pregnant Saudi women during the childbearing age: A cross-sectional study

Refaat¹

2015

Biomed J

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Background:Little is known about the prevalence of thyroid disorders and their associated anemia in the Kingdom of Saudi Arabia. The aim of the current study was to measure the prevalence and types of thyroid disorders and their relationship with anemia frequency and types in non-pregnant Saudi females during the childbearing age. Methods:Blood samples were collected from 600 non-pregnant females (between ≥18 and ≤45 years) with no history of thyroid dysfunction, chronic diseases, and/or anemia to measure serum thyroid stimulating hormone (TSH), free T4, erythrocyte indices, and iron parameters. Results:Thyroid disorders were detected in 118 participants (19.6%), and occult hypothyroidism was the most prevalent type (70/118) followed by overt hypothyroidism (38/118) and hyperthyroidism (10/118). Anemia was detected in 52 females with abnormal thyroid (44%) and the prevalence was significantly higher (p < 0.05) compared to euthyroid (14.3%). The red blood cell (RBC) count, hemoglobin, hematocrit value, serum iron, and serum ferritin were significantly lower in thyroid disorder compared to euthyroid group (p < 0.05). Erythrocyte indices correlated significantly with serum free T4, while iron parameters correlated with serum TSH (p < 0.05). Conclusion: Thyroid disorders are common in non-pregnant females in the Western province of Saudi Arabia, and they are associated with an increase in the prevalence of both anemia and iron deficiency. Further studies are needed to determine the underlying mechanism (s) contributing to the development of thyroiditis-induced anemia in the kingdom and the role of thyroid hormones in iron metabolism. (Biomed J 2015;38:307-316)

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Prevalence and characteristics of anemia associated with thyroid disorders in non-pregnant Saudi women during the childbearing age: A cross-sectional study

Refaat¹

2015

Biomed J

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“…The non-transcriptional effects are induced by the effect of TH on various ion channels. 35,36 All these cardiac effects, along with low peripheral vascular resistance and increase in total blood volume, lead to a high cardiac output state (often called ''high-output heart failure''). However, ''heart failure'' is not really the appropriate term because cardiac output is increased, although congestive circulation is present ( Table 3).…”

Section: Special Considerations Heart Failure In Hyperthyroidismmentioning

confidence: 99%

Effects of thyroid hormones on the heart

Vargas‐Uricoechea

Bonelo-Perdomo

Sierra‐Torres

2014

Clínica e Investigación en Arteriosclerosis

115

101

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“…[3] The most frequently encountered type of anemia is normochromic normocytic anemia. The most frequent reason of this is the bone marrow repression due to thyroid hormone deficiency which also causes defective erythropoietin production.…”

Section: Introductionmentioning

confidence: 99%