Thyroid hormones and erythropoiesis: A complex relation?

Schindhelm, Roger K.; Boekel, Edwin ten; Heima, Nathalie E.; Schoor, Natasja M. van; Şimşek, Suat

doi:10.1016/j.ejim.2013.03.018

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…Methimazole or subsequent radioiodine therapy of patients with hyperthyroidism reduced erythrocytosis and thyroid function returned to normal, suggesting that thyroid hormone promotes erythrocytosis [ 44 ]. Moreover, recent population-based studies on euthyroid subjects revealed a significant positive association between thyroid hormones and erythrocyte indices, such as erythrocyte counts, and hemoglobin levels [ 45 ]; [ 46 ]. These association studies support the notion that thyroid hormones stimulate erythropoiesis.…”

Section: Discussionmentioning

confidence: 99%

Defective erythropoiesis caused by mutations of the thyroid hormone receptor α gene

et al. 2017

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Patients with mutations of the THRA gene exhibit classical features of hypothyroidism, including erythroid disorders. We previously created a mutant mouse expressing a mutated TRα1 (denoted as PV; Thra1PV/+ mouse) that faithfully reproduces the classical hypothyroidism seen in patients. Using Thra1PV/+ mice, we explored how the TRα1PV mutant acted to cause abnormalities in erythropoiesis. Thra1PV/+ mice exhibited abnormal red blood cell indices similarly as reported for patients. The total bone marrow cells and erythrocytic progenitors were markedly reduced in the bone marrow of Thra1PV/+ mice. In vitro terminal differentiation assays showed a significant reduction of mature erythrocytes in Thra1PV/+ mice. In wild-type mice, the clonogenic potential of progenitors in the erythrocytic lineage was stimulated by thyroid hormone (T3), suggesting that T3 could directly accelerate the differentiation of progenitors to mature erythrocytes. Analysis of gene expression profiles showed that the key regulator of erythropoiesis, the Gata-1 gene, and its regulated genes, such as the Klf1, β-globin, dematin genes, CAII, band3 and eALAS genes, involved in the maturation of erythrocytes, was decreased in the bone marrow cells of Thra1PV/+ mice. We further elucidated that the Gata-1 gene was a T3-directly regulated gene and that TRα1PV could impair erythropoiesis via repression of the Gata-1 gene and its regulated genes. These results provide new insights into how TRα1 mutants acted to cause erythroid abnormalities in patients with mutations of the THRA gene. Importantly, the Thra1PV/+ mouse could serve as a preclinical mouse model to identify novel molecular targets for treatment of erythroid disorders.

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Section: Discussionmentioning

confidence: 99%

Defective erythropoiesis caused by mutations of the thyroid hormone receptor α gene

et al. 2017

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“…Thyroid hormones exert a wide range of functions in several organs, including cardiovascular system, lipid metabolism, muscular function, erythropoiesis, and oxidative stress . They also exert various effects on nervous system.…”

Section: Introductionmentioning

confidence: 99%

Thyroid function in elderly people: The role of subclinical thyroid disorders in cognitive function and mood alterations

et al. 2018

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Thyroid hormones exert a wide range of functions in several organs, including cardiovascular system, 1,2 lipid metabolism, 3-5 muscular function, 6 erythropoiesis, 7 and oxidative stress. 8 They also exert various effects on nervous system. Overt thyroid disorders are associated with several forms of cognitive impairment, depression, anxiety disorders, and peripheral neuropathies. 9,10 Cognition consists of several and specific neuronal systems which include attention, perception, memory, language, psychomotor, and executive functions. All these aspects, together with mood decrements, may be deeply affected by thyroid disease. Overt hypothyroidism has been linked with negative effects to various aspects of cognition. Cognitive deficits have also been reported in overt hyperthyroidism, being poorer performance on tests of attention, memory, or mental alertness the cognitive deficits most frequently observed. 11,12 Thyroid function changes with age, and since cogni-DELITALA ET AL. AUTH O R ' S CO NTR I B UTI O N Alessandro P Delitala helped in article designing and drafting; Marta Manzocco and Federico G Sinibaldi provided support in data collection and article drafting; and Giuseppe Fanciulli did critical revision of the article. O RCI D Alessandro P. Delitala

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Thyroid hormones and erythropoiesis: A complex relation?

Cited by 2 publications

References 6 publications

Defective erythropoiesis caused by mutations of the thyroid hormone receptor α gene

Defective erythropoiesis caused by mutations of the thyroid hormone receptor α gene

Thyroid function in elderly people: The role of subclinical thyroid disorders in cognitive function and mood alterations

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