2021
DOI: 10.1016/j.pnpbp.2021.110402
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Thyroid hormones in persons with schizophrenia: A systematic review and meta-analysis

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Cited by 38 publications
(28 citation statements)
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“…Deviations from the norm in the group of patients with schizophrenia are widely described in the literature. According to a meta-analysis from 2021, an increased level of TSH was observed in patients with multiple psychotic episodes in relation to healthy people, while in patients in the first psychosis, a reduction in TSH and FT3 levels and an increase in FT4 levels compared to the control group were observed [61]. The authors of the quoted study point out the need to understand the mechanisms of HPT axis deviations in patients with schizophrenia.…”
Section: Discussionmentioning
confidence: 99%
“…Deviations from the norm in the group of patients with schizophrenia are widely described in the literature. According to a meta-analysis from 2021, an increased level of TSH was observed in patients with multiple psychotic episodes in relation to healthy people, while in patients in the first psychosis, a reduction in TSH and FT3 levels and an increase in FT4 levels compared to the control group were observed [61]. The authors of the quoted study point out the need to understand the mechanisms of HPT axis deviations in patients with schizophrenia.…”
Section: Discussionmentioning
confidence: 99%
“…A systematic review analyzing the function of thyroid hormones, which enrolled 19 studies, demonstrated that the level of TSH might be abnormal in either first-episode schizophrenia patients or multiple-episode schizophrenia patients. Moreover, the level of TSH was fluctuating along with the course of schizophrenia ( 19 ).…”
Section: Introductionmentioning
confidence: 99%
“…Less frequently, persistent headaches, gait disturbances, isolated nystagmus, opsoclonus-myoclonus syndrome, parkinsonian syndromes, spastic paraparesis, fatigue syndrome, sleep disturbances or visual and auditory hallucinations have been reported [ 60 , 61 ]. Patients treated for many years for schizophrenia, depressive disorders, Alzheimer’s disease or drug-resistant epilepsy have been described, in whom HE was finally diagnosed and corticosteroid therapy resulted in complete resolution of symptoms [ 82 , 85 ]. On the other hand, when analyzing the relationship between psychiatric disorders and thyroid diseases, Hashimoto’s thyroiditis, even in euthyroid state, increases the risk of their occurrence [ 86 ].…”
Section: Resultsmentioning
confidence: 99%