Thyroid hormones, iodine and iodides, and antithyroid drugs

Ling, Hua; Patel, Anuj; Park, Jonathan; Bhave, Vishakha

doi:10.1016/bs.seda.2019.07.019

Cited by 1 publication

(2 citation statements)

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“…Antithyroid drugs, which operate by inhibiting thyroid hormone synthesis, are intended for the treatment of hyperthyroidism (2,29). Thioamides, which are represented by methimazole (MMI), carbimazole and propylthiouracil (PTU), act by inhibiting thyroid peroxidase, which is responsible for iodine organification and synthesis of thyroid hormones (29,30). These drugs cannot, however, affect the liberation of already synthetized hormones or interact with exogenously administered levothyroxine (31,32).…”

Section: Indication and Dosagementioning

confidence: 99%

“…MMI and PTU are the most commonly available, whereas carbimazole (methimazole prodrug) is available only in some countries (33). Both MMI and PTU are equally effective; however, MMI is more commonly used due to a better safety profile and favorable pharmacokinetics (2,29). These drugs are used for the management of hyperthyroidism, including the treatment of Graves' disease and thyrotoxicosis (only PTU in cases of excessive hormones release, since it inhibits the peripheral conversion of T4 to T3); amelioration of hyperthyroidism in preparation for surgical treatment; an adjunct to radioactive iodine therapy; in juvenile hyperthyroidism, to delay ablative therapy and to manage thyrotoxic crisis (only PTU) (31,32,34).…”

Section: Indication and Dosagementioning

confidence: 99%

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Role of pharmacists in management of patients with thyroid disorders

Homšek¹,

Roganović²,

Kovačević³

et al. 2022

Arhiv za farmaciju

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Thyroid dysfunction is one of the most prevalent endocrine disorders, especially common in female patients. If patients are not diagnosed in time or adequately treated, the patients' quality of life can be significantly impaired and additional health problems may occur, considering the key roles of thyroid hormones in the body. Therefore, it is necessary to raise awareness about the importance of recognition of symptoms that may indicate a potential problem with the thyroid gland and help to identify possible causes. For patients who are already being treated with levothyroxine (hypothyroidism), or thiamazole, carbimazole or propylthiouracil (hyperthyroidism), it is necessary to point out the necessity of proper, regular use of the drugs and implementation of accompanying nonpharmacological measures, as well as the potential for the occurrence of adverse reactions and interactions with other drugs or food. A significant role in the mentioned activities should be played by the pharmacist, as the most accessible member of the health team, who can, if necessary, refer the patient to a doctor for diagnosis, monitor the effectiveness and safety of the therapy, and provide appropriate patient counseling.

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Section: Indication and Dosagementioning

confidence: 99%

Section: Indication and Dosagementioning

confidence: 99%