Thyroid hormones, lipid profile and anthropometric changes after programmed weight loss in Palestinian obese adult females

Mwafy, Saleh; Yassin, Maged M.; Mousa, Raed

doi:10.1016/j.dsx.2017.12.009

Cited by 10 publications

(9 citation statements)

References 26 publications

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“…In this study, FGF21 was shown to reduce BW in obese minipigs, mainly by reducing food intake, but the fact that EE was not measured is a major limitation. These data are in line with the lack of UCP‐1‐mediated EE in this species; however, interestingly, a 0.3 mg/kg dose of FGF21 increased both total and free T3, which may have prevented a potential down‐regulation of EE as observed during weight loss in humans . The data are also in agreement with data from one of the studies on UCP‐1 knockout mice in which FGF21 lowered body weight by decreasing food intake .…”

Section: Discussionsupporting

confidence: 88%

“…These data are in line with the lack of UCP-1-mediated EE in this species; however, interestingly, a 0.3 mg/kg dose of FGF21 increased both total and free T3, which may have prevented a potential down-regulation of EE as observed during weight loss in humans. 35 The data are also in agreement with data from one of the studies on UCP-1 knockout mice in which FGF21 lowered body weight by decreasing food intake. 17 The appetite-reducing effect of FGF21 is not well described, but an activation of FGF21 receptors in the area postrema, 27 which is well known to regulate appetite, may be involved.…”

Section: Discussionsupporting

confidence: 85%

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FGF21 decreases food intake and body weight in obese Göttingen minipigs

Christoffersen¹,

Straarup²,

Lykkegaard³

et al. 2018

Diabetes Obesity Metabolism

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Aims The aim of this study was to assess the effect of FGF21 on food intake, body weight, body composition, glucose homeostasis, bone mineral density (BMD), cortisol and growth hormone (GH) in obese minipigs. The pig is a unique model for studying FGF21 pharmacology as it does not express UCP1, unlike mice and humans. Methods Twelve obese Göttingen minipigs with a mean body weight of 91.6 ± 6.7 kg (mean ± SD) received subcutaneously either vehicle (n = 6) or recombinant human FGF21 (n = 6) once daily for 14 weeks (0.1 mg/kg for 9.5 weeks and 0.3 mg/kg for 4.5 weeks). Results Treatment of obese minipigs with FGF21 led to a 50% reduction in food intake and a body weight loss of, on average, 18 kg compared to the vehicle group after 14 weeks of dosing. Glucose tolerance and insulin sensitivity, evaluated by intravenous glucose tolerance test, were significantly improved in the FGF21 group compared to the vehicle group at the end of the study. The plasma cortisol profile was unaffected by FGF21, whereas a small decrease in peak GH values was observed in the FGF21‐treated animals after 7 to 9.5 weeks of treatment compared to the vehicle group. Whole‐body BMD was not affected by 13 weeks of FGF21 dosing. Conclusion Despite a lack of UCP‐1 in obese minipigs, FGF21 treatment induced a significant weight loss, primarily a result of reduction in food intake, with no adverse effect on BMD or plasma cortisol.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 85%

FGF21 decreases food intake and body weight in obese Göttingen minipigs

Christoffersen¹,

Straarup²,

Lykkegaard³

et al. 2018

Diabetes Obesity Metabolism

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“…(2017) have reported that there was no significant differences in TSH hormone value of short-term eccentric exercises. In another study, it was stated that diet and six-month exercise program increased the TSH value in Palestinian obese women, and T3 and T4 levels decreased significantly compared to the pre-study period (Mwafy, Yassin & Mousa, 2018). Çolak, Kıyıcı, Eroğlu, Ağırbaş, Ağgön & Uçan (2015) have reported that high intensity acute sauna and wrestling exercises had significant changes in thyroid hormone metabolism.…”

Section: Discussionmentioning

confidence: 99%

The Effect of High Intensity Interval Training Applied with Vitamin E Reinforcement on Thyroid Hormone Metabolism

Akbulut

Çınar

Erdoğan

2019

RREM

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The aim of the present research was to investigate the effect of vitamin E supplement applied with high intensity interval trainings (HIIT) on the thyroid hormone values. The research group consisted of 12 voluntary male sportsman; High intensity interval training and supplement groups (HIIT+V). HIIT group was participated only tabata model training program 3 days for 8 weeks. The HIIT+ V group was taken the vitamin e in addition to the trainings. Blood samples were taken two times from the participants in the resting situation baseline and after the trainings session. Thyroid hormones were analyzed in the serum values taken from obtained the bloods of individuals. SPSS program was used in order to the data. Analysis results demonstrated that, There were no significant differences in comparison the groups (p>0,05). Within group analysis; T3, T4 and TSH was different in the HIIT+V group, while it found significant change only in TSH level in the HIIT group. Conclusion, it was found that the 8weeks of HIIT and Vitamin E reinforcement affect the thyroid hormones levels. It could said that interval trainings may lead to changes in thyroid hormones levels and may more effective when applied with vitamin E.

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“…It is known that thyroid hormones have an active role in many metabolic events besides lipid and glucose metabolism. With the effect of thyroid hormones on lipid metabolism, it can lower cholesterol levels in the organism and helps in the regulation of endocrine disorders, preventing cardiovascular disorders by providing improvement in lipid profile (Chi et al, 2013;Dillmann, 2010;Mask and Barnwal, 2016;Mwafy et al, 2018;Pascual and Aranda, 2013;Song et al, 2011;Teixeira et al, 2017;Yehuda-Shnaidman et al, 2013). It is known that thyroid hormone metabolism is affected with the exercises, and when the structural and functional properties of the thyroid are taken into consideration, it has been revealed that it is associated with rare elements (Calcium, Magnesium, Sodium, Chromium, Cobalt, Iodine, Iron, Selenium, Manganese, Zinc).…”

Section: Introductionmentioning

confidence: 99%

Effects of Endurance Workouts on Thyroid Hormone Metabolism and Biochemical Markers in Athletes

Erdoğan

2020

BRAIN

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Objective: Exercises can create differences in the organism by affecting the hormonal system and hemostasis. Evaluation of hormonal changes along with physical activity, many factors such as physical and physiological state of athletes, environmental factors and nutritional status are effective and affect the performance. In this study, as a result of endurance workouts, chronic changes in athletes' thyroid hormone metabolism and biochemical markers were evaluated. Method: 16 male athletes formed the research group. The athletes participating in the study received endurance training for 60 minutes a day, three days a week for 12 weeks. Blood samples were taken from the athletes before the session and after the session. The levels of Thyroid hormones, iron, iron binding capacity, UIBC, erythrocyte, leukocyte and platelet were determined in blood samples. Data were considered by using SPSS statistical package software. Findings: A significant difference was observed in athletes' thyroid hormone values as a result of the training sessions: Thyroid Stimulating Hormone (TSH), Thyroxine (T4) and Triiodothyronine (T3) levels were detected to be statistically different in pre-post test (p <0,05). As a result of the applied workouts changes were observed in the erythrocyte, leukocyte and platelet values of the athletes, and a significant difference was seen in general (p <0,05). Results: Applied regular and long-term endurance training created differences in athletes' thyroid hormone metabolism and biochemical markers. It is thought that these findings will positively affect the fight against the stress experienced by athletes during their competitions and increase their performance.

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Thyroid hormones, lipid profile and anthropometric changes after programmed weight loss in Palestinian obese adult females

Cited by 10 publications

References 26 publications

FGF21 decreases food intake and body weight in obese Göttingen minipigs

FGF21 decreases food intake and body weight in obese Göttingen minipigs

The Effect of High Intensity Interval Training Applied with Vitamin E Reinforcement on Thyroid Hormone Metabolism

Effects of Endurance Workouts on Thyroid Hormone Metabolism and Biochemical Markers in Athletes

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