Thyroid Hormones, Oxidative Stress, and Inflammation

Mancini, Antonio; Segni, Chantal Di; Raimondo, Sebastiano; Olivieri, G.; Silvestrini, Andrea; Meucci, Elisabetta; Currò, Diego

doi:10.1155/2016/6757154

Cited by 374 publications

(299 citation statements)

References 139 publications

(144 reference statements)

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“…These conflicting results suggest that the effects of TH on neutrophil ROS generation cannot be entirely explained by direct effects of TH on these cells. The link between TH metabolism and oxidative stress that occurs outside innate immune cells has been reviewed elsewhere and is beyond the scope of this review (Mancini et al 2016).…”

Section: Effects Of Thyroid Hormones On Neutrophil Functionmentioning

confidence: 99%

Thyroid hormone metabolism in innate immune cells

Spek

Fliers

Boelen

2017

Journal of Endocrinology

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Thyroid hormone (TH) metabolism and thyroid status have been linked to various aspects of the immune response. There is extensive literature available on the effects of thyroid hormone on innate immune cells. However, only recently have authors begun to study the mechanisms behind these effects and the role of intracellular TH metabolism in innate immune cell function during inflammation. This review provides an overview of the molecular machinery of intracellular TH metabolism present in neutrophils, macrophages and dendritic cells and the role and effects of intracellular TH metabolism in these cells. Circulating TH levels have a profound effect on neutrophil, macrophage and dendritic cell function. In general, increased TH levels result in an amplification of the pro-inflammatory response of these cells. The mechanisms behind these effects include both genomic and non-genomic effects of TH. Besides a pro-inflammatory effect induced by extracellular TH, the cellular response to pro-inflammatory stimuli appears to be dependent on functional intracellular TH metabolism. This is illustrated by the fact that the deiodinase enzymes and in some cell types also thyroid hormone receptors appear to be crucial for adequate innate immune cell function. This overview of the literature suggests that TH metabolism plays an important role in the host defence against infection through the modulation of innate immune cell function.

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Section: Effects Of Thyroid Hormones On Neutrophil Functionmentioning

confidence: 99%

Thyroid hormone metabolism in innate immune cells

Spek

Fliers

Boelen

2017

Journal of Endocrinology

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“…4,5 The infection induces infiltration of polymorphonuclear that if nor cleared effectively, than replaced gradually by an immunologically-mediated, chronic, and latter induce pro-inflammatory cytokines production by local or systemic, 1,2-6 as aresult, gastric epthelium is not the only one target of H pylori pathologic manifestationbut also affected to some extradigestive conditions, including endocrine disorders, including autoimmune thyroid disorders (ATD) such as autoimmune atrophic thyroiditis and Hashimoto's thyroiditis, or thyroid mucosal associated lymphocyte tissue (MALT) lymphoma that has been epidemiologically proven,. 1,7,8 Even there have been controversial report about the link between H pylori infection and thyroid disorders, but some studies have been sucsesfully reported an increased prevalence of H pylori in people with ATD and relationship between H pylori infection and the presence of high titers of thyroid auto-antibodies, such as antithyroglobulin (anti-Tg) and anti-thyroperoxidase (anti-TPO) antibodies resulting in abnormalities of gastric secrtory fuction. 1 Other studies have been demonstrated that some bacteria and viruses are able to mimic the antigenic profile of the thyroid cell membrane, thereby playing an important role in the pathogenesis of autoimmune diseases.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the thyroid may be the target by autontibodies after H pylori infection. 1,7,8 Chronic inflammation that caused by H pylori can induces oxidative stress that has been shown to be associated with both hyperthyroidism and hypothyroidism. 8,9 however the mechanisms of oxidative stress generated in to hypothyroidism is low availability of antioxidants.…”

Section: Introductionmentioning

confidence: 99%

“…1,7,8 Chronic inflammation that caused by H pylori can induces oxidative stress that has been shown to be associated with both hyperthyroidism and hypothyroidism. 8,9 however the mechanisms of oxidative stress generated in to hypothyroidism is low availability of antioxidants. 9',10 Therefore, we conducted a cross-sectional study to investigate whether correlation between H. pylori infection and T3 serum level also thyroid-stimulating hormone serum level.…”

Section: Introductionmentioning

confidence: 99%

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Helicobacter Pylori is associated with decrease serum level of the thyroid hormonal in healthy elderly population

Suwarni¹,

Cilmiaty²,

Indarto³

et al. 2017

Bangladesh J Med Sci

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Background:Helicobacter pylori infection is the most prevalence infectious disease as it affects more than half of the world population and causes chronic cellular inflammatory response in the gastric mucosa. Helicobacter pylori infection has been epidemiologically proven to be linked to extra-digestive conditions and disease. It has been speculated that H.pylori infection may be responsible for various endocrine disorders. The thyroid may be one of the targets of Helicobacter pylori chronic inflammation. Here we sought too investigate whether H.pylori infections were associated with decrease level of the thyroid hormonal. Methods: This study involved elderly aged 50-90 years who had visited a health promotion center for elderly. A total 101 euthyroid subjects were been enrolled in this cross-sectional study. Diagnosed of Helicobacter.pylori infections by ELISA of Ig G antibodies of Helicobacter pylori. We examine serum T3 level and serum TSH level by ELEXIS. For statistical method we use Pearson bivariat analysis to determine the association of two variable,and linier regression to determine which variable is more influented by Helicobacter pylori. Results: Fourty-two (41,6 %) subjects had been diagnosed with H.pylori infections. Pearson bivariat analysis showed that Helicobacter pylori infection was significantly associated with decreased serum T3 level ( correlations coefficient r = -0,66 ,p< 0,001 ). The prevalence of Helicobacter pylori infection showed a increasing trend as serum TSH level decreased (correlations coefficient r = -0,53, p < 0,001). Linier regression analysis showed thatHelicobacter pylori infection was significantly associated with the risk of decreased thyroid hormonal fuction ( B = -0,272. R 2 = 0,676. P < 0.001 ). Conclusion: Our results suggested that H.pylori infections were significantly associated with the decreased serum level of T3 and TSH serum level in the healthy elderly population, whose thyroid functions were in the reference range.

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“…In this case, the key connection between the inflammatory and oxidative stress and the development of atherosclerosis is increased level of C-reactive protein (CRP) [8,11]. It was established that the increased activity of low-intensity inflammation, the most studied marker of which is CRP, is very important for the development of both inflammatory and non-inflammatory thyropathies of different genesis [4,7,9].…”

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confidence: 99%