Thyroid hormones promote differentiation of oligodendrocyte progenitor cells and improve remyelination after cuprizone-induced demyelination

Franco, Paula; Silvestroff, Lucas; Soto, Eduardo F.; Pasquini, Juana M.

doi:10.1016/j.expneurol.2008.04.039

Cited by 133 publications

(120 citation statements)

References 41 publications

Supporting

Mentioning

110

Contrasting

Order By: Relevance

“…PLP gene encodes the myelin protein PLP indicating increased rate of differentiation of OPCs into mature OLGs induced by treatment of T3 in acute phase of demyelination. However, myelin formation as indicated by MBP immunonohistochemistry was not significantly increased in T3 treated group after one week of cuprizone withdrawal to the contrary of Franco et al (2008) who reported that T3 treatment induced significant increase of MBP immunohistochemistry after one week of cuprizone withdrawal. In this study, MBP immunonohistochemistry became significantly higher in T3 treated group compared to animals recovering spontaneously after three weeks of T3 treatment indicating enhanced remyelination.…”

Section: Discussioncontrasting

confidence: 58%

“…However, Franco et al (2008) observed that maximum demyelination was detected histologically one week after cuprizone withdrawal with significant decrease in MBP expression.…”

Section: Discussionmentioning

confidence: 92%

“…Group IV (triiodothyronine treated = T3 treated) (n = 18): rats were fed on standard rodent chow mixed with cuprizone 0.6% (w/w) for 2 weeks then returned to a normal diet with standard rodent chow. On the third week the rats were treated with three subcutaneous injections of triiodothyronine (T3) (Sigma Aldrich) 20 g/100 g body weight day after day (Franco et al, 2008). The animals of this group were divided into two subgroups sacrificed at the end of the third week (n = 12) and the fifth week (n = 6).…”

Section: Experimental Designmentioning

confidence: 99%

“…There is strong evidence supporting that thyroid hormone (TH) acts directly on oligodendrocytes differentiation and maturation processes which has been extensively studied during brain development (Franco et al, 2008). However, TH can also modify the proliferative activity and maturation of OPCs in mature brain (Fernandez et al, 2004) suggesting that OPCs in adult brain are still sensitive to signaling molecules known to regulate oligodendrogenesis during development (Franco et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…However, TH can also modify the proliferative activity and maturation of OPCs in mature brain (Fernandez et al, 2004) suggesting that OPCs in adult brain are still sensitive to signaling molecules known to regulate oligodendrogenesis during development (Franco et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

The effect of triiodothyronine on maturation and differentiation of oligodendrocyte progenitor cells during remyelination following induced demyelination in male albino rat

et al. 2016

View full text Add to dashboard Cite

a b s t r a c tDemyelination was induced by two weeks cuprizone treatment. Rats of +ve control and triiodothyronine (T3) then received three subcutaneous injections of either saline or T3 day after day and sacrificed at the end of the third and fifth weeks. Animals in −ve control group received only standard rodent chow. After one week of cuprizone withdrawal the corpus callosum in +ve control and T3 treated rats was still demyelinated as revealed by MBP immunohistochemistry. The assay of PLP gene showed significant increase of T3 treated group compared to both the −ve control and +ve control groups. After three weeks, significant improvement in myelination was detected in T3-treated group compared to +ve control as detected by both MBP immunohistochemistry and electron microscopy. After one week of cuprizone withdrawal, PDGFR␣ positive cells and gene expression showed significant increase in +ve control and T3-treated groups as compared to −ve control with insignificant difference in between the former two groups. After three weeks of cuprizone withdrawal, PDGFR␣ positive cells in T3-treated and +ve control groups decreased to the control levels. These results suggest that T3 was effective in improving remyelination when administered during acute phase and might direct progenitor lineage toward oligodendrocytes.

show abstract

Section: Discussioncontrasting

confidence: 58%

“…However, Franco et al (2008) observed that maximum demyelination was detected histologically one week after cuprizone withdrawal with significant decrease in MBP expression.…”

Section: Discussionmentioning

confidence: 92%

Section: Experimental Designmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The effect of triiodothyronine on maturation and differentiation of oligodendrocyte progenitor cells during remyelination following induced demyelination in male albino rat

et al. 2016

View full text Add to dashboard Cite

show abstract

Role of the Thyroid System in Myelination and Neural Connectivity

Calzà

Fernández

Giardino

2015

Comprehensive Physiology

View full text Add to dashboard Cite

The role of thyroid hormone on brain development is dramatically illustrated by "cretinism," a severe mental retardation due to iodine deficiency and maternal hypothyroidism during gestation. In the last decades, the molecular bases of the cellular action of thyroid hormone in the nervous tissue have been at least partially elucidated, and the emerged picture is much more complex than expected. In this article, the main mechanisms determining thyroid hormone availability, nuclear and membrane receptor occupancy and downstream action, gene expression, and nongenomic mechanism are reviewed, focusing on myelination and myelin turnover.

show abstract

G protein‐coupled receptor 30 contributes to improved remyelination after cuprizone‐induced demyelination

Hirahara

Matsuda

Yamada

et al. 2012

Glia

View full text Add to dashboard Cite

Estrogen exerts neuroprotective and promyelinating actions. The therapeutic effect has been shown in animal models of multiple sclerosis, in which the myelin sheath is specifically destroyed in the central nervous system. However, it remains unproven whether estrogen is directly involved in remyelination via the myelin producing cells, oligodendrocytes, or which estrogen receptors are involved. In this study, we found that the membrane-associated estrogen receptor, the G protein-coupled receptor 30 (GPR30), also known as GPER, was expressed in oligodendrocytes in rat spinal cord and corpus callosum. Moreover, GPR30 was expressed throughout oligodendrocyte differentiation and promyelinating stages in primary oligodendrocyte cultures derived from rat spinal cords and brains. To evaluate the role of signaling via GPR30 in promyelination, a specific agonist for GPR30, G1, was administered to a rat model of demyelination induced by cuprizone treatment. Histological examination of the corpus callosum with oligodendrocyte differentiation stage-specific markers showed that G1 enhanced oligodendrocyte maturation in corpus callosum of cuprizone-treated animals. It also enhanced oligodendrocyte ensheathment of dorsal root ganglion (DRG) neurons in co-culture and myelination in cuprizone-treated animals. This study is the first evidence that GPR30 signaling promotes remyelination by oligodendrocytes after demyelination. GPR30 ligands may provide a novel therapy for the treatment of multiple sclerosis.

show abstract

Thyroid hormones promote differentiation of oligodendrocyte progenitor cells and improve remyelination after cuprizone-induced demyelination

Cited by 133 publications

References 41 publications

The effect of triiodothyronine on maturation and differentiation of oligodendrocyte progenitor cells during remyelination following induced demyelination in male albino rat

The effect of triiodothyronine on maturation and differentiation of oligodendrocyte progenitor cells during remyelination following induced demyelination in male albino rat

Role of the Thyroid System in Myelination and Neural Connectivity

G protein‐coupled receptor 30 contributes to improved remyelination after cuprizone‐induced demyelination

Contact Info

Product

Resources

About