Thyroid hormones regulate cardiac repolarization and QT-interval related gene expression in hiPSC cardiomyocytes

Ulivieri, Alessandra; Lavra, Luca; Magi, Fiorenza; Morgante, Alessandra; Calò, Leonardo; Polisca, Patrizio; Salehi, Leila; Sciacchitano, Salvatore

doi:10.1038/s41598-021-04659-w

Cited by 6 publications

(4 citation statements)

References 80 publications

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“…Thyroid dysfunctions have a known influence on cardiomyocytes with increased cardiac contractility and rate, and risk of proarrhythmic effects. 32 This study shows the ECG changes in TDs that make it easier for physicians to apply in routine clinics. Moreover, it tries to link the pathophysiological changes in ECG changes with TD.…”

Section: Discussionmentioning

confidence: 83%

Assessment of Electrocardiographic Changes and Associated Factors Among Thyroid Dysfunction Patients Attending Jimma Medical Center, Southwest Ethiopia: A Cross-Sectional Study

Zeleke,

Badanie,

Asefa

et al. 2023

IJGM

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Background Thyroid dysfunction (TD) is a metabolic manifestation related to either excessive or inadequate production of thyroid hormones. It has been widely proven to have comorbidities like cardiovascular disease. An electrocardiograph is a simple investigative instrument used to assess cardiac status to prevent complications in the later stages of the disease. Objective To assess electrocardiogram (ECG) changes and associated factors among TD patients. Methods An institution-based cross-sectional study was conducted among 273 TD patients attending Jimma Medical Center from October 11 to December 11, 2021. An ECG tool with 12 leads was used to assess the cardiac status, and a semi-structured questionnaire was used to assess sociodemographic, behavioral, and comorbidity variables. Bodyweight, height, waist circumference (WC), hip circumference (HC), and blood pressure variables were recorded, and body mass index (BMI) and waist-to-hip ratio (WHR) were calculated. Results Out of a total of 273 analyzed and interpreted ECG results by the cardiologists, 185 (67.8%) had ECG alterations. The most common types of ECG changes were arrhythmia 153 (56%), followed by myocardial infarction 74 (27.1%), ventricular hypertrophy [left 20 (7.3%) and right 15 (5.5%)], left atrial enlargement 3 (1%), axis deviation, and other abnormalities 24 (8.8%) and 18 (6.6%), respectively. The identified predictor variables for the ECG changes were the age group of 41 to 60 years old [AOR = 2.5, 95% CI: 1.25, 5.05], being female [AOR = 2.7, 95% CI: 1.28, 5.59], having diabetes mellitus [AOR = 4.25, 95% CI: 1.6, 11.2], and not starting the treatment [AOR = 8.6, 95% CI: 3.45, 21.6]. Conclusion This study revealed that the prevalence of ECG changes was high among TD patients. The most common type of ECG change observed was arrhythmia followed by myocardial infarction. The age range of 41–60 years old, being female, having diabetes mellitus, and not starting the treatment were significantly associated with the ECG changes. Implementing an efficient noninvasive screening of cardiac status can detect unrecognized and asymptomatic cardiac impairment in TD patients.

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Section: Discussionmentioning

confidence: 83%

Assessment of Electrocardiographic Changes and Associated Factors Among Thyroid Dysfunction Patients Attending Jimma Medical Center, Southwest Ethiopia: A Cross-Sectional Study

Zeleke,

Badanie,

Asefa

et al. 2023

IJGM

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“…In the vandetanib Phase 3 trial for MTC patients, more study subjects in the vandetanib group developed QTc prolongation compared to the placebo group (35% vs. 3%) [ 8 ]. Physicians should carefully monitor patients′ thyroid function, as hypothyroidism could be associated with QTc prolongation [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Initial Experiences of Selective RET Inhibitor Selpercatinib in Adults with Metastatic Differentiated Thyroid Carcinoma and Medullary Thyroid Carcinoma: Real-World Case Series in Korea

Baek

et al. 2023

Current Oncology

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Recently, selpercatinib, a highly selective inhibitor of RET receptor tyrosine kinase, has been used for RET-altered thyroid cancer. We present four cases of patients with advanced thyroid cancer who were treated with selpercatinib. The first patient was a 63-year-old male with advanced medullary thyroid cancer (MTC) treated with vandetanib. Six months ago, he had an intracranial hemorrhage and swallowing difficulty. He started selpercatinib with percutaneous endoscopic gastrostomy (PEG). For 11 months, a partial response (PR) was observed stably with PEG administration without any more cardiovascular events. The second patient was a 67-year-old female with advanced MTC treated with vandetatib. After selpercatinib treatment, a PR was observed for most metastatic sites, including choroidal metastasis. The third patient was a 32-year-old female with advanced papillary thyroid cancer (PTC) without history of systematic treatment. For six months, a PR was observed at her metastatic site with manageable adverse events. The last patient was a 59-year-old female with advanced PTC treated with lenvatinib. She suffered from a panic disorder and pleural pain due to metastasis during lenvatinib treatment. After selpercatinib treatment, her pain and panic symptoms were improved. Facing varying clinical obstacles of the real world, selpercatinib safely proved remarkable therapeutic efficacy regardless of previous treatment or metastatic site.

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“…[76] Ulivieri et al proved that thyroid hormones T3 and T4 regulate the repolarization of the QT-interval. [101] Additionally, glucocorticoids represent a group of hormones that play a key role in myofibril alignment and construction improving the overall maturity of iPSC-CM. [102] The major sources of energy for CM in vivo are glucose and fatty acids.…”

Section: Biochemical Stimulationmentioning

confidence: 99%

Advancing Cardiomyocyte Maturation: Current Strategies and Promising Conductive Polymer‐Based Approaches

Elkhoury,

Kodeih,

Enciso‐Martínez

et al. 2024

Adv Healthcare Materials

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Cardiovascular diseases are a leading cause of mortality and pose a significant burden on healthcare systems worldwide. Despite remarkable progress in medical research, the development of effective cardiovascular drugs has been hindered by high failure rates and escalating costs. One contributing factor is the limited availability of mature cardiomyocytes (CMs) for accurate disease modeling and drug screening. Human induced pluripotent stem cell‐derived CMs offer a promising source of CMs; however, their immature phenotype presents challenges in translational applications. This review focuses on the road to achieving mature CMs by summarizing the major differences between immature and mature CMs, discussing the importance of adult‐like CMs for drug discovery, highlighting the limitations of current strategies, and exploring potential solutions using electro‐mechano active polymer‐based scaffolds based on conductive polymers. However, critical considerations such as the trade‐off between three‐dimensional systems and nutrient exchange, biocompatibility, degradation, cell adhesion, longevity, and integration into wider systems must be carefully evaluated. Continued advancements in these areas will contribute to a better understanding of cardiac diseases, improved drug discovery, and the development of personalized treatment strategies for patients with cardiovascular disorders.This article is protected by copyright. All rights reserved

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Thyroid hormones regulate cardiac repolarization and QT-interval related gene expression in hiPSC cardiomyocytes

Cited by 6 publications

References 80 publications

Assessment of Electrocardiographic Changes and Associated Factors Among Thyroid Dysfunction Patients Attending Jimma Medical Center, Southwest Ethiopia: A Cross-Sectional Study

Assessment of Electrocardiographic Changes and Associated Factors Among Thyroid Dysfunction Patients Attending Jimma Medical Center, Southwest Ethiopia: A Cross-Sectional Study

Initial Experiences of Selective RET Inhibitor Selpercatinib in Adults with Metastatic Differentiated Thyroid Carcinoma and Medullary Thyroid Carcinoma: Real-World Case Series in Korea

Advancing Cardiomyocyte Maturation: Current Strategies and Promising Conductive Polymer‐Based Approaches

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