Thyroid incidentalomas detected on 18F-fluorodeoxyglucose-positron emission tomography/computed tomography: Thyroid Imaging Reporting and Data System (TIRADS) in the diagnosis and management of patients

Yoon, Jung Hyun; Cho, Arthur; Lee, Hye Sun; Kim, Min Jung; Moon, Hee Jung; Kwak, Jin Young

doi:10.1016/j.surg.2015.03.017

Cited by 25 publications

(24 citation statements)

References 18 publications

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“…Also in patients with the clinical risk factors mentioned in Table 1 and with the high pretest likelihood for thyroid cancer associated with these features, FNA at sizes lower than those recommended can be considered [1, 13]. PET positive nodules have a higher incidence of malignancy ~40–45 % and FNA is recommended in nodules > 1 cm [1, 57, 58]. …”

Section: Diagnosis and Evaluation Of Thyroid Nodulesmentioning

confidence: 99%

Thyroid nodule update on diagnosis and management

Tamhane

Gharib

2016

Clin Diabetes Endocrinol

129

109

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Thyroid nodules are common. The clinical importance of thyroid nodules is related to excluding malignancy (4.0 to 6.5% of all thyroid nodules), evaluate their functional status and assess for the presence of pressure symptoms. Incidental thyroid nodules are being diagnosed with increasing frequency in the recent years with the use of newer and highly sensitive imaging techniques. The high prevalence of thyroid nodules necessitates that the clinicians use evidence-based approaches for their assessment and management. New molecular tests have been developed to help with evaluation of malignancy in thyroid nodules. This review addresses advances in thyroid nodule evaluation, and their management considering the current guidelines and supporting evidence.

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Section: Diagnosis and Evaluation Of Thyroid Nodulesmentioning

confidence: 99%

Thyroid nodule update on diagnosis and management

Tamhane

Gharib

2016

Clin Diabetes Endocrinol

129

109

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“…Five comparatively small studies included 238 participants (272 nodules), 105 participants (nodules not reported), 100 participants (157 nodules), 100 participants (nodules not reported), and 84 participants (87 nodules) [17-19, 22,23]. A total of 9,010 participants (10,611 nodules) were reported from all studies [14][15][16][17][18][19][20][21][22][23][24][25]. The proportion of participants who were male (nodules from male participants) reported from studies ranged from 14% to 33% (20-29%) [15][16][17][18][19]22,23].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…A total of 9,010 participants (10,611 nodules) were reported from all studies [14][15][16][17][18][19][20][21][22][23][24][25]. The proportion of participants who were male (nodules from male participants) reported from studies ranged from 14% to 33% (20-29%) [15][16][17][18][19]22,23]. The mean age of all participants was relatively consistent and reported to be 46-59 years [15,16,[18][19][20]23].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The proportion of participants who were male (nodules from male participants) reported from studies ranged from 14% to 33% (20-29%) [15][16][17][18][19]22,23]. The mean age of all participants was relatively consistent and reported to be 46-59 years [15,16,[18][19][20]23]. One study reported the mean age only for participants with benign and malignant nodules: 42 and 43 years, respectively [17].…”

Section: Study Characteristicsmentioning

confidence: 99%

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Ultrasound Classification of Thyroid Nodules: A Systematic Review

Mistry¹,

Hillyar²,

Nibber³

et al. 2020

Cureus

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Ultrasound (US) based classification systems exist for the stratification of thyroid nodules based on the risk for malignancy. This systematic review aimed to assess the evidence for the performance of US-based thyroid nodule classification systems through correlation with fine needle aspiration biopsy (FNAB). PubMed and Scopus were searched using keywords that included 'ultrasound classification', 'thyroid nodules', 'fine needle aspiration', and 'malignancy'. Inclusion criteria were as follows: studies/reviews reporting on US imaging for the classification of thyroid nodules. Exclusion criteria were as follows: no comparison between US imaging findings and histology reports based on FNAB, no full English text available/accessible. The database searches identified 66 publications. After evaluation, 12 studies met the inclusion criteria. Two US-based classification systems for thyroid nodules were assessed: the Thyroid Imaging Reporting and Data System (TIRADS) and the American Thyroid Association (ATA) guidelines. For TIRADS, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) ranged from 70.6% to 97.4%, 29.3% to 90.4%, 23.3% to 64.3%, and 87.1% to 99.0%, respectively. The median sensitivity, specificity, PPV, and NPV for TIRADS was 90.0%, 57.4%, 49.0%, and 91.0%, respectively. One study comparing TIRADS with the ATA guidelines demonstrated that TIRADS was superior in terms of sensitivity, whereas the ATA guidelines were superior in terms of specificity and PPV. The high sensitivity and NPV of the US-based TIRADS classification system have excellent utility for correctly classifying nodules as positive for malignant disease and for predicting the absence of malignant disease. The paucity of studies assessing the ATA guidelines highlights avenues for further research comparing TIRADS with other systems of thyroid nodule classification.

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“…18 F-FDG PET/CT-positive thyroid nodules tend to have higher rates of malignancy, which should be further investigated by thyroid ultrasonography to enlightment for the features of thyroid nodules. ultrasonography are hypoechogenicity, taller than wider appearance, irregular margins, hypervascularity, and microcalcifications (7). Many authorities, including the American Thyroid Association (ATA), recommend fine needle aspiration biopsy (FNAB) for exclusion of malignancy in thyroid nodules (8).…”

Section: Introductionmentioning

confidence: 99%

Hounsfield unit value has null effect on thyroid nodules at 18F-FDG PET/CT scans

Haydardedeoğlu¹,

Bağır²,

Torun³

et al. 2018

Archives of Endocrinology and Metabolism

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Objectives: Detection rate of thyroid nodules is increasing with the use of new imaging modalities, especially in screening for malignancies. Positron emission tomography/computed tomography (PET/ CT)-positive thyroid nodules should be differentiated for malignancy to avoid unnecessary operations and further follow-up. Most trials evaluate the role of SUV max , but there is no definitive information about the utility of Hounsfield unit (HU) values for prediction of malignancy. This study aimed to evaluate the HU values beside SUV max for detecting malignancy risk of PET/CT-positive thyroid nodules. Subjects and methods: Results of 98 cancer patients who had fine needle aspiration biopsy (FNAB) for thyroid nodules detected on PET/CT between January 2011 and December 2015 were assessed. The FNABs and surgical pathological results were recorded. Results: FNABs revealed benign results in 32 patients (32.7%), malignant in 18 (18.4%), non-diagnostic in 20 (20.4%), and indeterminate in 28 (28.5%). Twenty-four patients underwent thyroidectomy. The mean HU values were not significantly different in benign and malignant nodules (p = 0.73). However, the mean SUV max was significantly higher (p < 0.001) in malignant ones. Area under curve (AUC) was 0.824 for SUV max ; the cutoff value was over 5.55 (p < 0.001), with 80% sensitivity, 84.5% specificity. Conclusions: Our current study demonstrated that HU value does not add any additional valuable information for discriminating between malignant and benign thyroid nodules. We also defined a SUV max cutoff value of 5.55 for malignant potential of thyroid nodules detected on PET/CT.

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Thyroid incidentalomas detected on 18F-fluorodeoxyglucose-positron emission tomography/computed tomography: Thyroid Imaging Reporting and Data System (TIRADS) in the diagnosis and management of patients

Cited by 25 publications

References 18 publications

Thyroid nodule update on diagnosis and management

Thyroid nodule update on diagnosis and management

Ultrasound Classification of Thyroid Nodules: A Systematic Review

Hounsfield unit value has null effect on thyroid nodules at 18F-FDG PET/CT scans

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