Thyroid-like follicular carcinoma of the kidney - Case report

Thyroid-like follicular carcinoma of the kidney: A Case report

“…Primary thyroid-like follicular carcinoma of the kidney(TLFCK) is a least-frequent and least-studied variant of renal tumor, named purely from the light microscopic appearance, with well-circumscribed pseudocapsules resembling to thyroid follicular carcinoma microscopically but negative for the thyroid-specific markers [2,3,15]. In all reported cases, there were no significant distinguish from other types of renal tumor on location and clinical performance.…”

“…Morphologically, TLFCK consists of different sized follicular structures containing abundant eosinophilic colloid resembling to the well-differentiated follicular thyroid carcinoma, as a comparison, TLFCK show a obviously different morphological features from other types of renal carcinoma [6]. Immunohistocemically, TLFCK has a typical negative performance of thyroid immunohistochemical markers, like thyroid transcription factor-1(TTF1) and thyroglobulin(TG), respectively, the staining of CD10 and CK17 is variable [1,3,5,7]. In this case, Immunohistochemical results show a positive result of CK7, and negative result of TTF1, TG, P504S, CD117, meeting the diagnostic criteria of TLFCK.…”

“…TLFCK is a kind rare pathological type of renal tumor, which is potentially considered origining in the renal parenchymal urinary tubule epithelial system [1]. This unique histopathological type of RCC(renal cell carcinoma), described firstly in 1996 by Angell et al, had not been recorded in the 2004 world health organization in account of the lack of sufficient clinical evidence that only 28 cases reported in the English literature to date [2][3][4][5][6][7][8][9][10][11][12][13][14][15]. TLFCK has a similar feature with the follicular carcinoma of the thyroid in morphology.…”

Thyroid follicular carcinoma-like renal tumor

“…Clinical data [1,3–29] showed more female patients than male patients were affected by this type of tumor (27/12 cases), and the age of onset was 19 to 83 years, with a mean age of 43 years and a median age of 39 years, of which 33 patients were in the range of 19 to 60 years, suggesting that the tumors often occur in young and middle-aged populations. Most cases were incidentally discovered (23 cases); some were associated with urinary system symptoms, mainly hematuria and flank pain (16 cases), and 1 case was discovered in autopsy.…”

“…Regarding treatment and prognosis, surgical resection is the main treatment method for TFCLRT. According to the literature, [1,3–29] most tumors with diameters of more than 4 cm or associated with invasive growth or distant metastasis are treated mainly with radical nephrectomy, combined with the corresponding regional lymph node dissection; tumors with diameters of < 6 cm, a complete capsule, and no metastasis are mainly treated with partial nephrectomy or tumor enucleation. The available data suggest that TFCLRT is a type of tumor with a low degree of malignancy, a low recurrence rate (1 case of suspected recurrence [24] ), and a low rate of metastasis (5/40 cases) and has minimal progression after surgery.…”