Thyroid-like follicular carcinoma of the kidney: a case report and review of the literature

Ghaouti, Merieme; Roquet, Laurence; Barón, M González; Pfister, Christian; Sabourin, Jean‐Christophe

doi:10.1186/s13000-014-0186-8

Cited by 17 publications

(14 citation statements)

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“…Hemorrhagic and necrotic areas are common and may present as intratumoral “cysts” (2, 8, 9). Histologically there are macro and microfollicles filled with amorphous eosinophilic colloid-like material (5, 10), similar to TFCC. The follicles are lined with cuboidal cells with scant eosinophilic cytoplasm, round/oval nuclei and evenly distributed chromatin.…”

Section: Discussion and Future Perspectivesmentioning

confidence: 96%

“…PET (+).Biopsy + P nephrectomy/ 21 months NED.Wang 2017 (2)25 FSevere hypertension (normal post-operative)Normal thyroid (I/F), normal ovaries (I)R MP 30(CT) inhomogenous enhancement, calcifications. Ovaries normal (imaging).P/ 2 years NED.Ghaouti 2014 (10)68 FIncidentalNormal thyroid (I/F), normal ovaries (I)R MP 11(MRI) Cystic, no enhancementP/ no FU reportedVolavsek 2013 (11)34 ?IncidentalNephrolithiasis,polycystic disease, adult type.L LP 50 mmHyperechogenic cystT/ 6 months NED.Sterlacci 2008 (6)28 FIncidental L MP 44(CT) Heterogeneous, no capsule infiltration, displacement of blood vessels. Left lung nodule.Thyroidectomy (presumed metastatic thyroid cancer, despite normal imaging).…”

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

“…Mitotic activity is absent or scarce. There may be focal areas of papillary differentiation, patchy lymphoid aggregates, calcifications (2, 3, 10-12) and cholesterol crystals (12). Fibrous septa presenting muscle and a fibrous pseudocapsule have been described (7, 12).…”

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

“…Tubular deposits of Tamm-Horsfall glicoprotein are probably the explanation for the colloidal aspect in kidney tumors, including TLCK (5, 10). …”

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

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Thyroid-like follicular carcinoma of the kidney presenting on a ten year-old prepubertal girl

et al. 2019

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The very rare thyroid-like carcinoma of the kidney (TLCK) is microscopically similar to thyroid follicular cell carcinoma (TFCC). Differential diagnosis with secondary thyroid tumors depends on non-reactivity to immunohistochemical (IHC) markers for TFCC (thyroglobulin - TG and TTF1). We herein describe the fourth Pediatric case in literature and extensively review the subject. Only 29 cases were published to the moment. Most cases were asymptomatic and incidentally detected. Most tumors are hyperechoic and hyperdense with low grade heterogenous enhancement on CT and MRI. Most patients were treated with radical nephrectomy, but partial nephrectomy was used in some cases, apparently with the same results. Metastases are uncommon and apparently do not change prognosis, but follow-ups are limited. Up to the moment, TLCK presents as a low grade malignancy that may be treated exclusively with surgery and frequently with partial kidney renal preservation. A preoperative percutaneous biopsy is a common procedure to investigate atypical tumors in childhood and adult tumors. To recognize the possibility of TLCK is fundamental to avoid unnecessary thyroidectomies in those patients, supposing a primary thyroid tumor.

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Section: Discussion and Future Perspectivesmentioning

confidence: 96%

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

“…Tubular deposits of Tamm-Horsfall glicoprotein are probably the explanation for the colloidal aspect in kidney tumors, including TLCK (5, 10). …”

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

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Thyroid-like follicular carcinoma of the kidney presenting on a ten year-old prepubertal girl

et al. 2019

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“…TLFCK is a kind rare pathological type of renal tumor, which is potentially considered origining in the renal parenchymal urinary tubule epithelial system [1]. This unique histopathological type of RCC(renal cell carcinoma), described firstly in 1996 by Angell et al, had not been recorded in the 2004 world health organization in account of the lack of sufficient clinical evidence that only 28 cases reported in the English literature to date [2][3][4][5][6][7][8][9][10][11][12][13][14][15]. TLFCK has a similar feature with the follicular carcinoma of the thyroid in morphology.…”

Section: Introductionmentioning

confidence: 99%

Thyroid-like follicular carcinoma of the kidney: A Case report

Pang¹,

Song²,

Guo³

et al. 2018

The Great Imposture: Eosinophilic Cholangitis

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Primary thyroid-like follicular carcinoma of the kidney (TLFCK) is a least-frequent and least-studied variant of renal tumor which is rich in follicular structures of colloidal substances, otherwise, it is typically negative for the thyroid immunohistochemical markers. We report a 44-year-old patient with mild anemia, who was found a right kidney occupying lesion incidentally during the medical examination. The microfollicular and macro-follicular structures under the microscope and typical negative performance of thyroid immunohistochemical markers is in line with the diagnosis of TLFCK. To our knowledge this is the first report of TLFCK with anemia. Brief review of previously published TLFCs, we discuss the clinical and histopathological features of limited cases.

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