Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: Case report and literature review

Oishi, Naoki; Kondo, Tetsuo; Nakazawa, Tadao; Mochizuki, Kazuki; Kasai, Kazunari; Inoue, Tomohiro; Yamamoto, Takanori; Watanabe, Hiroyuki; Hatsushika, Kyousuke; Masuyama, Keisuke; Katoh, Ryohei

doi:10.1016/j.prp.2014.04.020

Cited by 33 publications

(32 citation statements)

References 19 publications

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“…The most common IHC pattern of TL-LGNPPA tumour cells is TTF-1 positivity and TG negativity, which is negative for TTF-1 and diffusely positive for TG in PTC. Such finding has been reported in all previously reported cases of TL-LGNPPA as well as our patient 2–9. These two neoplasms have some similar IHC patterns including CK7 expression and vimentin 2.…”

Section: Discussionsupporting

confidence: 89%

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Thyroid-like low-grade papillary adenocarcinoma of nasopharynx

Sourati

Malekzadeh²,

Rakhshan

2019

BMJ Case Rep

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We report a 35-year-old woman with complaints of nasal obstruction and mild post-nasal drip for 6 months. She did not improve with medical treatment. Clinical examination had no positive finding. She was evaluated with a CT scan and MRI that revealed a polypoid mass lesion in nasopharynx without any adhesion to adjacent tissue. Endoscopic examination of nasopharynx revealed an exophytic nasopharyngeal mass in anterior wall of nasopharynx that complete macroscopic transnasal endoscopic resection was performed. The histopathological examination reported thyroid-like low-grade nasopharyngeal papillary adenocarcinoma that was confirmed on immunohistochemical staining. After complete macroscopic resection of the mass, patient was regularly followed-up for 6 years and there was no evidence of recurrence. This example has the educational tips of the optimal therapeutic strategies for primary nasopharyngeal adenocarcinomas with long follow-up.

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Section: Discussionsupporting

confidence: 89%

“…Thyroid-like LNPPA is an extremely rare tumour of nasopharynx with only a limited number of cases reported in the literature 2–9. NPPA includes 0.38%–0.48% of all malignant nasopharyngeal neoplasms 10.…”

Section: Discussionmentioning

confidence: 99%

Thyroid-like low-grade papillary adenocarcinoma of nasopharynx

Sourati

Malekzadeh²,

Rakhshan

2019

BMJ Case Rep

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“…Only 12 cases of TL-LGNPPA have been reported to date (3–12). In a review of the clinical characteristics of these tumours described in the previously published cases, Oishi et al (11) reported that the age of the patients ranged from 9 to 68 years (median, 34 years), with a male:female ratio of 1:1. TL-LGNPPA predominantly occurs in the roof of the nasopharynx and at the posterior edge of the nasal septum.…”

Section: Discussionmentioning

confidence: 99%

Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: A case report

Horino¹,

Ichii

Hamada‐Ode³

et al. 2016

Molecular and Clinical Oncology

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Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is a rare neoplasm characterized by morphological analogy to papillary thyroid carcinoma and abnormal expression of thyroid transcription factor-1 (TTF-1). We herein report a rare case of TL-LGNPPA with a review of its clinical, morphological and immunohistochemical characteristics. The patient was a 25-year-old Japanese woman complaining of a 2-year history of fever of unknown origin. There were no remarkable physical findings and the laboratory tests, including C-reactive protein levels, were normal. Laryngoscopy, magnetic resonance imaging and fluorodeoxyglucose-positron emission tomography identified a pedunculated mass at the roof of the nasopharynx. Histologically, the tumour exhibited papillary growth of cuboidal or columnar epithelium. Tubular architecture and a spindle cell component were also observed focally. Some tumour cells exhibited intranuclear cytoplasmic inclusions. Immunohistochemically, the neoplastic cells were positive for TTF-1, cytokeratin 7 and vimentin, but were negative for thyroglobulin. The Ki-67 labelling index (MIB-1 index) reached 5% in the most concentrated spot. The patient had neither local recurrence nor distant metastasis 3 years after removal of the tumour. In conclusion, TL-LGNPPA should be included it in the differential diagnosis of fever of unknown origin.

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“…Однако наличие лимфоцитов в опухолевом узле, как правило, не влияет на выбор тактики лечения [12][13][14]. Наличие лимфоцитарной инфильтрации, возможно, послужит началом разработки новых методов лечения НФК, [15,16]. Нами была проведена дифференциальная диагностика НФК с другими злокачественными новообразованиями носоглотки, которая отражена в таблице иммунофенотипирования (табл.…”

Section: результаты и обсуждениеunclassified

“…Кроме того, следует проводить дифференциальную диагностику с другими назофарингеальными опухолями, например с лимфомой (неходжкинской), аденокарциномой (из слизистых желез подслизистой оболочки) и лимфоидным кистозным раком (из малых слюнных желез носоглотки). Последние виды рака чаще встречаются в полости носа или ротовой полости [13][14][15].…”

Section: результаты и обсуждениеunclassified

The specific immunophenotypic features of nasopharyngeal carcinoma

Demyashkin

Кастыро

Сидорин³

et al. 2018

Vestn. otorinolaringol.

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Назофарингеальная карцинома (НФК, рак носоглотки) является одной из самых сложных опухолей с точки зрения правильной постановки диагноза на начальном этапе из-за отсутствия специфических назальных симптомов. Кроме того, НФК является сравнительно редкой опухолью. Так, в России удельный вес рака носоглотки состав-ляет около 0,1-0,2% в структуре онкологической заболеваемости. У мужчин заболеваемость НФК достигает 0,55 случая на 100 000 населения (в европейских странах -0,9), у женщин -0,29 (в европейских странах -0,26) [1]. В Япо-https://doi.

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Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: Case report and literature review

Cited by 33 publications

References 19 publications

Thyroid-like low-grade papillary adenocarcinoma of nasopharynx

Thyroid-like low-grade papillary adenocarcinoma of nasopharynx

Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: A case report

The specific immunophenotypic features of nasopharyngeal carcinoma

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