Thyroid Malignancy in Multi Nodular Goiter;

Nadeem, K.; Akhtar, Naveed; Tarar, Javed Mirdad

doi:10.29309/tpmj/2013.20.04.1098

Cited by 9 publications

(3 citation statements)

References 3 publications

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“…23 Yong et al (2017) observed this frequency to be 14.3% in Singapore while Fama et al (2018) reported it to be 12.1% in Italy. 31,30 The current study adds to the body of locally and globally published research evidence on the subject. The present study's tight exclusion criteria and large sample size of 84 cases were its strongest points.…”

Section: Discussionmentioning

confidence: 91%

Frequency of Thyroid Carcinoma in Multi Nodular Goiter

Khan¹,

Khan²,

Jogezai³

et al. 2023

PJMHS

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Objective: The objective of this study was to determine the frequency of thyroid carcinoma in patients presenting with multinodular goiter in BMCH. Study Settings: Research was conducted at Department of General Surgery, Bolan Medical Complex Hospital Quetta. Material and Methods: Eighty four patients from both the genders with age between 20-75 years presenting with multinodular goiter since 3 months and meeting inclusion criteria were included in this study after taking informed written consent. All the thyroidectomies were done by consultant general surgeon of the hospital. Post-operatively all the patients were managed as per hospital protocol. Post thyroidectomy specimen was sent for histopathology for diagnosis of thyroid malignancy as per operational definition. All the other findings of study variables such as age, gender, place of residence, BMI (weight in Kg/Height in m2), family history of malignancy, diabetes, hypertension, smoking (>5 cigarettes/day for 2 years) and duration of goiter were noted in a predesigned proforma. Results: The mean age of the patients was 37.4±14.0 years. Majority (n=48, 57.1%) of the patients were aged between 25-50 years, followed by 23 (27.4%) patients aged <25 years and 13 (15.5%) patients aged >50 years. There were 17 (20.2%) male and 67 (79.8%) female patients with a male to female ratio of 1:4. Family history of thyroid malignancy was positive in 11 (13.1%) patients. Thyroid carcinoma was detected in 12 (14.3%) patients with multinodular goiter. When stratified, the frequency of thyroid carcinoma was significantly higher among smokers (29.2% vs. 8.3%; p-value=0.014) and those with positive family history of thyroid cancer (36.4% vs. 11.0%; p-value=0.047). However, no statistically significant difference was observed across various subgroups of patients based on age (p-value=0.978), gender (p-value=1.000), BMI (p-value=1.000), duration of goiter (p-value=0.928), place of residence (p-value=1.000), diabetes (p-value=0.928) and hypertension (p-value=0.858). Conclusion: In the present study, we observed that a substantial proportion of patients with multinodular goiter had concealed thyroid carcinoma particularly smokers and those with positive family history which warrants careful pre-operative evaluation of such patients for thyroid malignancy so that it may be identified well in time and appropriate management may be initiated to improve outcomes in future practice. Keywords: Multinodular Goiter, Thyroid Carcinoma, Positive Family History, Smoking

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Section: Discussionmentioning

confidence: 91%

Frequency of Thyroid Carcinoma in Multi Nodular Goiter

Khan¹,

Khan²,

Jogezai³

et al. 2023

PJMHS

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“…Ghadhban et al reported an increased malignancy rate of 21.7% in cases with MNG, with papillary carcinoma accounting for 80% and follicular carcinoma accounting for 19.2% of the lesions [ 13 ]. According to another study by Nadeem et al, the incidence of cancer in MNG is 10.2% [ 20 ]. Thus, our findings were consistent with the published research.…”

Section: Discussionmentioning

confidence: 99%

Frequency and Type of Thyroid Carcinoma in Patients With Multinodular Goiter

Amin¹,

Amjad²,

Farman³

et al. 2023

Cureus

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BackgroundThis study aimed to investigate the incidence and subtype of thyroid cancer in multinodular goitre (MNG) patients who underwent total thyroidectomy. MethodologyA cross-sectional study was conducted at the Khyber Teaching Hospital, screening 207 MNG patients who received complete thyroidectomies between July and December 2022. The senior consultant diagnosed thyroid cancer based on a complete history, physical examination, and laboratory and radiological studies. Ultrasound-guided fine-needle aspiration cytology was performed by a senior consultant radiologist. Bethesda categories for all lesions were recorded. All patients underwent thyroidectomy, and the diagnosis of thyroid cancer was confirmed on histopathology. ResultsA total of 207 patients were included in the study, with a mean age of 45.55 ± 8.75 years. Out of 207 patients, 24 (11.59%) were diagnosed with thyroid cancer. Out of 62 male patients, 15 (7.25%) had thyroid cancer. Out of 145 female patients, only nine had cancer (p < 0.001). Nine patients with thyroid cancer had a body mass index (BMI) below 18, compared to only five patients with a BMI of more than 30 kg/m 2 . The difference in age distribution was not significant in our study (p = 0.102). ConclusionIn conclusion, our study sheds light on the frequency and potential risk factors associated with thyroid cancer in patients with multinodular goiter. Our findings reveal that papillary thyroid carcinoma is the most commonly observed form of thyroid cancer in this patient population, with around 12 percent of patients diagnosed with thyroid cancer. Notably, our study highlights that male patients and those with a lower BMI may have a greater risk of developing thyroid cancer in the context of multinodular goiter. The findings of this study have important implications for the care and follow-up of MNG patients who receive total thyroidectomy. Further research is needed to investigate the type and prognosis of thyroid cancer in patients with MNG.

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“…Goiter is caused mainly by iodine deficiency in the diet or by high concentrations of goitrogens, radiation, and environmental factors with a resultant increment of thyroid-stimulating hormone (TSH) that causes enhanced follicular cell hyperplasia. [1][2][3][4][5][6][7][8] The presence of thyroid nodules can be associated with compression of the esophagus, hoarseness of voice, dysphagia, cosmetic and psychologic impact, and, of course, carcinoma. 3 As a result, proper preoperative assessment and surgical therapeutic solutions should be standard procedures in patient care.…”

Section: Introductionmentioning

confidence: 99%

Thyroid Malignancy in Patients Who Underwent Thyroidectomy for Multinodular Goiter and Solitary Thyroid Nodule

Gedamu,

Shimels,

Kassie

et al. 2024

JCO Glob Oncol

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PURPOSE Worldwide, incidence of thyroid malignancy is increasing. The purpose of this study was to evaluate the pattern and magnitude of nodule types. METHODS A cross-sectional retrospective study was performed at Saint Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia, among patients who underwent thyroidectomy from May 2018 to June 2022. Data were extracted using a structured format. Descriptive statistics were performed using SPSS version 26 software. Results were presented in terms of percentages and frequencies. RESULTS During a 4-year period, 1,476 patients had thyroidectomies and histopathologic information of 212 malignant cases was studied. Within multinodular goiter (MNG), thyroid cancer accounted for 69.8% (n = 148) of patients, whereas in solitary nodules, it accounted for 30.2%. From the total, 160 participants (75.5%) were female, and the female:male ratio was 3.1 (mean, 41.72; ± standard deviation [SD], 16.44) years, and age range of 12-88 years versus men, who have a mean of 44.71 (±SD, 14.91) years and an age range of 21-78 years. The mean age of male cases with solitary nodule and MNG was 40.6 and 46.5 years, respectively. The most frequent cancer in both types of nodules, accounting for 59% of patients, was papillary carcinoma, which was found in 64% of solitary nodules and 57.4% of multinodular nodules. Overall, 14.1% of tumors had multiple centers (17.4% in multinodular nodules and 6.9% in solitary nodules). In 7.1% of patients, microcarcinoma (<1 cm) was found, with papillary carcinoma accounting for 91.7% of the total. CONCLUSION Compared with men, women with cancer typically manifested at a younger age. Males with malignancy in solitary nodules had a lower mean age than those with MNGs. The most frequent and significant cause of multicentric presentation is papillary carcinoma.

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Thyroid Malignancy in Multi Nodular Goiter;

Cited by 9 publications

References 3 publications

Frequency of Thyroid Carcinoma in Multi Nodular Goiter

Frequency of Thyroid Carcinoma in Multi Nodular Goiter

Frequency and Type of Thyroid Carcinoma in Patients With Multinodular Goiter

Thyroid Malignancy in Patients Who Underwent Thyroidectomy for Multinodular Goiter and Solitary Thyroid Nodule

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