Thyroid Metastasis from Primary Breast Cancer

Patrizio, Armando; Ferrari, Silvia; Stoppini, Giulio; Palmisano, Elena; Elia, Giusy; Ragusa, Francesca; Paparo, Sabrina Rosaria; Balestri, Eugenia; Mazzi, Valeria; Botrini, Chiara; Proietti, Agnese; Famà, Fausto; Benvenga, Salvatore; Antonelli, Alessandro; Fallahi, Poupak

doi:10.3390/jcm12072709

Cited by 4 publications

(2 citation statements)

References 63 publications

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“… HT patients demonstrated a (x40–80) increased risk for developing PTL [ 2 , 35 ], especially Maltoma, whereas 78% of PTL patients had some evidence of HT subtype [ 1 , 3 , 4 , 5 , 12 , 15 , 32 , 35 ]. Dysthyroidism is common in long standing HT, and was exceptionally reported in cases of ATC ([ 36 ] or MTT [ 36 , 37 ] and in iatrogenic cases [ 38 ]. *Hypoparathyroidism was recently reported as due to concomitant thyroid and parathyroid gland metastasis [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

“…Dysthyroidism is common in long standing HT, and was exceptionally reported in cases of ATC ([ 36 ] or MTT [ 36 , 37 ] and in iatrogenic cases [ 38 ]. *Hypoparathyroidism was recently reported as due to concomitant thyroid and parathyroid gland metastasis [ 37 ]. CNB is a rapid and safe procedure with higher performance compared to FNAC in identifying the histotype CNB is a rapid and safe procedure with higher performance compared to FNAC in identifying the histotype of large and rapidly growing thyroid masses [ 35 , 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

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Fast Track Management of Primary Thyroid Lymphoma in the Very Elderly Patient

Marcy¹,

Bauduer

Thariat

et al. 2023

Current Oncology

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A rapid growing cervical mass mobile while swallowing is the most common clinical presentation of severe thyroid malignancy. A 91-year-old female patient with a history of Hashimoto thyroiditis presented with clinical compressive neck symptoms. The patient had gastric Maltoma diagnosed that was surgically resected thirty years ago. A straightforward process was needed to reach full histological diagnosis and initiate prompt therapy. Ultrasound (US) showed a 67 mm hypoechoic left thyroid mass with reticulated pattern without signs of locoregional invasion. Percutaneous trans isthmic US-guided 18G core needle biopsy (CNB) disclosed diffuse large B cell lymphoma of the thyroid gland. FDG PET revealed two distinct thyroid and gastric foci (both SUVmax 39.1). Therapy was initiated rapidly to decrease clinical symptoms in this aggressive stage III primitive malignant thyroid lymphoma. The prognostic nomogram was calculated by using a seven-item scale, which disclosed a one-year overall survival rate of 52%. The patient underwent three R-CVP chemotherapy courses, then refused further treatment and died within five months. Real-time US-guided CNB approach led to rapid patient’s management that was tailored to patient’s characteristics. Transformation of Maltoma into diffuse large B cell lymphoma (DLBCL) into two body areas is deemed to be extremely rare.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Fast Track Management of Primary Thyroid Lymphoma in the Very Elderly Patient

Marcy¹,

Bauduer

Thariat

et al. 2023

Current Oncology

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Thyroid gland: a rare site of metastasis

Orlandi,

Alcaraz,

Bielski

et al. 2024

Endocrine

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Purpose: Despite its rich vascularity, metastasis (MTS) to the thyroid tissue is unusual, ranging from 1 to 3%. This entity is not usually considered as differential diagnosis and is not included in the upfront approach in patients with thyroid nodules. Once diagnosed, treatment is controversial. The aim of this study was to evaluate diagnosis, treatment and outcome at the end of follow-up in patients with a diagnosis of MTS to the thyroid.Methods: A retrospective multicenter study was designed from 1985 to 2022; 29 patients with MTS to the thyroid gland were included in the analysis.Results: Clinical presentation included the presence of a thyroid nodule (65.5%), compression symptoms (17.2%), diffuse goiter (10.3%), and suspicious lymph nodes in the neck (7%). Primary tumor sites were: kidney (44.8%), breast (24.1%), lung (13.8%), neuroendocrine system (6.9%), colon (3.4%), cervix (3.4%), and ovary (3.4%). In 18/23 patients, suspicious ultrasound criteria for malignancy were described.Preoperative diagnosis was made in 23/27 patients by FNA, and con rmed in 18 cases by immunohistochemistry. Seventeen patients underwent surgery. At the end of follow-up, 19 patients had died of oncological disease, and 6 were alive (2/6 disease-free with isolated intra-thyroidal MTS).Conclusion: Renal carcinoma was the tumor that most frequently metastasized to the thyroid gland.Immunodiagnosis was a very useful tool for etiological con rmation. Patients with MTS to the thyroid gland as a unique site had a more favorable course compared to patients with multiple metastatic sites.Finally, outcomes and prognosis essentially depended on the biology of the primary tumor.

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Clinicopathological features and outcomes of rare lung adenocarcinoma metastasis to the thyroid gland: A single‐center, 11‐year experience

Gao,

Cao,

Diao

et al. 2024

Thoracic Cancer

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BackgroundMetastasis to the thyroid gland from lung adenocarcinoma is rare and challenging to diagnose due to similar histopathological features. This study aimed to analyze the clinicopathological characteristics of and treatment strategies for lung adenocarcinoma metastasis to the thyroid based on 11 years of institutional experience.MethodsA retrospective study included patients with lung adenocarcinoma metastasis to the thyroid at our center from 2010 to 2023. Clinicopathological features and clinical outcomes were analyzed.ResultsAmong 9714 lung adenocarcinoma patients, nine patients (five females, 55.6%) were diagnosed with thyroid metastasis, presenting primarily with cough symptoms. Most patients (88.9%) had synchronous tumors, whereas a minority (11.1%) had metachronous tumors. The median time from primary tumor diagnosis to metastasis was 4.8 months. Most patients developed bilateral thyroid metastases (88.9%). Diagnosis of thyroid metastasis was primarily through fine‐needle aspiration (FNA), with one case misdiagnosed as papillary thyroid carcinoma. Immunohistochemical staining revealed thyroid transcription factor‐1 (TTF‐1) and novel aspartic proteinase of pepsin family A (Napsin‐A) positivity and paired box 8 (PAX8) negativity. Genetic testing found epidermal growth factor receptor mutations in 71.4% of patients. The individualized comprehensive therapy included surgery, chemotherapy, immunotherapy, and targeted and supportive therapy. The median overall survival was 56.0 months, with a progression‐free survival of 12.7 months. Kaplan–Meier (K–M) analysis suggested improved survival with no advanced symptoms (p = 0.03) and targeted therapies (p = 0.05).ConclusionsLung adenocarcinoma metastasis to the thyroid is a rare disease, with an incidence of 0.1% among lung adenocarcinoma patients. Early treatment after symptom onset and personalized targeted therapies may improve prognosis. Despite rapid disease progression, favorable outcomes can be achieved with comprehensive treatment.

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Thyroid Metastasis from Primary Breast Cancer

Cited by 4 publications

References 63 publications

Fast Track Management of Primary Thyroid Lymphoma in the Very Elderly Patient

Fast Track Management of Primary Thyroid Lymphoma in the Very Elderly Patient

Thyroid gland: a rare site of metastasis

Clinicopathological features and outcomes of rare lung adenocarcinoma metastasis to the thyroid gland: A single‐center, 11‐year experience

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