Thyroid Neoplasia Following Radiation Therapy for Hodgkin's Lymphoma

McHenry, Christopher R.; Jarosz, H; Calandra, D; McCall, Anne R.; Lawrence, A. M.; Paloyan, Edward

doi:10.1001/archsurg.1987.01400180066012

Cited by 14 publications

(6 citation statements)

References 12 publications

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“…Few reports appear in the literature documenting the association between thyroid and thymic malignancy [ 1 1,121. Only a single report of two cases linking these synchronous cancers to childhood irradiation was discovered in our literature search [9] and in exhaustive reviews by others [ 1,3,4,[6][7][8][9]131. Occasional reports have noted nonmalignant tumors of the two glands [12,14] speculated to be due to similar endodermal tissues of origin [ 1 1 , 1 6 1 61.…”

Section: Discussionmentioning

confidence: 99%

“…Very few cases of post irradiation invasive thymoma have been documented [ 141, although experimentally, radiation-induced mouse thymomas are used for study [21]. Childhood radiation followed by development of papillary cancer of the thyroid is well known and well documented [1][2][3][4][5][6][7][8][9]131. Both low-dose and high-dose radiation appear to induce later carcinomas [ 1,4].…”

Section: Discussionmentioning

confidence: 99%

“…Childhood radiation followed by development of papillary cancer of the thyroid is well known and well documented [1][2][3][4][5][6][7][8][9]131. Both low-dose and high-dose radiation appear to induce later carcinomas [ 1,4]. Low-CONCLUSION A woman received radiation to her mediastinurn at 6 months of age for an enlarged thymus and later developed invasive thymoma and papillary cancer of her thyroid.…”

Section: Discussionmentioning

confidence: 99%

“…Debulking of the mediastinal tumor mass through a dose radiation has been used in the past for pediatric problems, such as enlarged thymus or tonsils, hemangioma, and acne [5]. High-dose radiation has been used more recently for Hodgkin's or pediatric head and neck tumors [3,4]. In all groups, increased rates of thyroid tumors and thyroid cancers were identified, with an average latency period of 17-39 years [2,4].…”

Section: Case Reportmentioning

confidence: 99%

“…The patient who presented to our facility had her first thyroid cancer diagnosed at 37 years of age. The object lesson to be learned is that if aggressive surgical management (total thyroidectomy) had been carried out initially, as others suggest [4,6], perhaps the unfortunate circumstance of widespread disease could have been avoided. This is important to remember because the observed higher incidence of nodal metastases in radiation-induced papillary thyroid cancer suggests a more aggressive behavior [ 131.…”

Section: Case Reportmentioning

confidence: 99%

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Thyroid and thymic malignancy following childhood irradiation

Jensen

Antonenko

1992

Journal of Surgical Oncology

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Synchronous thyroid and thymic malignancy following childhood thymic irradiation has only been reported in two known cases previously, with a third case identified here. A rationale is presented for following these radiated patients as they age with thyroglobulin and thyroid-stimulating hormone (TSH) levels as a measure of risk of the development of nodular thyroid disease and, if such occurs, for an aggressive surgical approach. There exists a growing population at risk attributable to the success of radiation treatment of Hodgkin's and pediatric head and neck tumors. The question is raised regarding the theoretical benefits of thyroid suppressive therapy in this group at risk. With the instructive case presented, radical surgery for either thymic or thyroid carcinoma and careful monitoring for decades-late local recurrences of thymoma are suggested.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

See 3 more Smart Citations

Thyroid and thymic malignancy following childhood irradiation

Jensen

Antonenko

1992

Journal of Surgical Oncology

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Papillary carcinoma of the thyroid

Cady¹

1991

Seminars in Surgical Oncology

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The clinical behavior and mortality rate of papillary carcinoma of the thyroid varies widely, and clinically insignificant microscopic foci of the disease are frequently found. Dietary iodine and radiation to the head and neck in childhood play a role in etiology. Needle aspiration cytology provides a highly accurate diagnosis. Ultrasound, radioactive iodine, and technetium scans are not specific and should only be used to complete diagnostic studies when aspiration cytology is negative for papillary carcinoma. The most important aspect of prognosis of an individual patient with papillary carcinoma of the thyroid is the age at which the disease is diagnosed, with an excellent prognosis, even in advanced primary disease or extensive lymph node involvement, in children and young adults. A multifactorial clinical risk group definition (AMES) is easy to use and reliably separates patients into low risk and high risk. Since 90% of patients with this disease rarely have metastases or late complications from the cancer, total or subtotal thyroidectomy is necessary in only 10% of cases for later use of postoperative radioactive iodine. More conservative surgical procedures are advised in low-risk patients. Papillary carcinoma incidentally found during operation for other conditions such as Graves disease or thyroiditis and reported first on the permanent pathology reports are always clinically insignificant and completely cured by removal; total thyroidectomy should be completely avoided. Postoperatively, thyroid hormone supplementation may be unnecessary after relatively conservative surgery in selected low-risk patients. Thyroid hormone must be maintained permanently after total or subtotal thyroidectomy.

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Follicular cell-derived thyroid carcinomas

Grebe¹,

Hay²

1997

Cancer Treatment and Research

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Thyroid Neoplasia Following Radiation Therapy for Hodgkin's Lymphoma

Cited by 14 publications

References 12 publications

Thyroid and thymic malignancy following childhood irradiation

Thyroid and thymic malignancy following childhood irradiation

Papillary carcinoma of the thyroid

Follicular cell-derived thyroid carcinomas

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