Thyroid Papillary Carcinoma in a 3-year-old American Boy with a Family History of Thyroid Cancer

Khara, Lovedeep; Silverman, Adam P.; Bethel, Colin; D'Cruz, Cyril; Sun, Xinlai

doi:10.1097/mph.0b013e3181c97c57

Cited by 11 publications

(12 citation statements)

References 18 publications

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“…Until reliable genetic testing becomes available, obtaining a detailed family history is of great importance for recognition of any familial link to FPTC. Recently, Khara et al reported a 3-year-old boy with familial PTC [ 16 ]. Since the patients in the second generation are frequently younger than the first generation counterparts, preoperative screening should be conducted at the age of 18 years according to expert consensus.…”

Section: Discussionmentioning

confidence: 99%

Single-center study of familial papillary thyroid cancer in China: surgical considerations

Lei

Wang

et al. 2015

World J Surg Onc

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BackgroundWhether familial papillary thyroid cancer (FPTC) is more aggressive than sporadic counterpart remains elusive, and the optimal clinical approach for FPTC is yet to be established. In this study, we investigated familial occurrence of PTC in China and reviewed our experience of its surgical treatment.MethodsThe clinical records of 248 consecutive patients with an established diagnosis of PTC who were admitted to Nanfang Hospital for thyroidectomy between January 2011 and June 2013 were analyzed in this study. Patients included 66 males and 182 females, aged 11 to 76 years.ResultsTwenty-two patients (8.9%) with a positive family history were confirmed. Patients with FPTC had a predilection for female subjects and tended to be younger than other patients, but the difference was not significant (P = 0.0514 and P = 0.168). They were more likely to present large tumors (P = 0.0024), multifocality (familial vs. sporadic: 54.50% vs. 26.50%; P < 0.006), local invasion (81.8% vs. 23.9%; P < 0.001), and malignant lymph nodes (63.6% vs. 33.6%; P = 0.005). Univariate and multivariate analyses identified that a positive family history was an independent risk factor for local invasion (OR: 5.683; 95% CI: 2.056 to 15.707; P = 0.001), malignant lymph nodes (OR: 3.005; 95% CI: 1.046 to 8.630; P = 0.041) in FPTC patients. Kaplan-Meier survival curves revealed that an aggressive surgical strategy was associated with a better relapse-free survival than conventional one (P = 0.032).ConclusionsFPTC is more likely to possess aggressive features than sporadic counterparts. Thus, screening of at-risk families is essential to aid in earlier recognition. An aggressive surgical strategy appeared to be the more effective therapy. However, sufficient detailed interrogation and long-term follow-up of the patients and their family are necessary for providing individualized recommendations for clinical management.

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Section: Discussionmentioning

confidence: 99%

Single-center study of familial papillary thyroid cancer in China: surgical considerations

Lei

Wang

et al. 2015

World J Surg Onc

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“…Since patients were frequently younger in the second generation as compared to first generation, screening should start at the age of 18 years. Recently, Khara et al reported a 3-year-old boy with familial PTC [30]. As soon as suspicious lesions are detected by ultrasound, total thyroidectomy seems to be the procedure of choice with regard to an often multifocal tumor growth of FNMTC.…”

Section: Recommendations For Treatment and Screening Of Fnmtcmentioning

confidence: 98%

Familial nonmedullary thyroid carcinoma—clinical relevance and prognosis. A European multicenter study

Hillenbrand

Varhaug

Brauckhoff

et al. 2010

Langenbecks Arch Surg

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“…The fPTC occurs most commonly, but it has also been described in other types of well-differentiated thyroid carcinoma (Ito et al, 2008). Khara et al (2010) described the appearance of fPTC in the case of a 3-year-old boy. Although the genes involved in the inheritance of the familial form of medullary thyroid carcinoma have been identified, the hereditary patterns of the fPTC are still unknown.…”

Section: Discussionmentioning

confidence: 99%

A case–control study of papillary thyroid cancer in children and adolescents

Živaljević

Tausanovic

Šipetić-Grujičić³

et al. 2013

European Journal of Cancer Prevention

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Thyroid carcinomas in children and adolescents are rare tumors and the most common among them is papillary thyroid cancer (PTC). Its etiology is still under research and has not been clearly defined thus far, especially in young individuals. The aim of this case-control study was to determine potential risk factors for the development of PTC in children and adolescents. This type of study has not been carried out previously in this age group. A case-control study was carried out during a 15-year period, between 1995 and 2009. The case group included 75 patients with PTC younger than 20 years of age, with the youngest patient being 6.5 years old; 45 patients were female and 30 were male. The control group included the same number of participants, and the cases were individually matched by sex, age, and place of residence. Conditional univariate and multivariate logistic regression methods were applied in data analysis. According to univariate logistic regression analysis, PTC in children and adolescents was significantly related to the following factors: family history of thyroid cancer, family history of residence in an endemic-goiter area, family history of benign thyroid disease, and family history of nonthyroid malignant tumors. According to the multivariate logistic regression method, PTC in children and adolescents was independently related to a family history of thyroid cancer (odds ratio=4.5, 95% confidence interval=1.2-19.8) and a family history of nonthyroid malignant tumors (odds ratio=3.8, 95% confidence interval=1.4-8.7). In conclusion, all of the factors associated with the development of PTC in children and adolescents were related to their family history.

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Thyroid Papillary Carcinoma in a 3-year-old American Boy with a Family History of Thyroid Cancer

Cited by 11 publications

References 18 publications

Single-center study of familial papillary thyroid cancer in China: surgical considerations

Single-center study of familial papillary thyroid cancer in China: surgical considerations

Familial nonmedullary thyroid carcinoma—clinical relevance and prognosis. A European multicenter study

A case–control study of papillary thyroid cancer in children and adolescents

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