Thyroid Pathology

Baloch, Zubair W.; LiVolsi, Virginia A.

doi:10.1007/978-3-540-68043-7_10

Cited by 3 publications

(3 citation statements)

References 338 publications

(315 reference statements)

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“…Interestingly enough, the number of foci was found to be higher in the tall cell variant, a feature that to the best of our knowledge has never been presented [1]. We can hypothesize, though, that the fact may be attributed to the much worse N status of these tumors in our series, which may indirectly be associated with the number of foci.…”

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confidence: 39%

Multifocal Versus Solitary Papillary Thyroid Carcinoma: Reply

Kiriakopoulos

Linos

2016

World j. surg.

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Thank you very much for your interest in our recent publication 'Multifocal versus Solitary Papillary Carcinoma.' In regard to your queries:1. Ten MFC cases (4.15% of all MFC cases) were truly incidental as the tumors were discovered postoperatively after the pathologic examination. In these cases, we had absolutely no clue about their existence in the preoperative setting, whereas these tumors were discovered by the meticulous study done by our dedicated pathologist. Interestingly enough, from the rest of the MFC cases, identification of at least two foci was accomplished successfully in the vast majority of patients. Whether our dedicated, specialized ultrasonographers were equally able to identify more than two foci on the preoperative setting is something that is open to a new study, but at this time we have no data on that. Nevertheless, specialized ultrasound examiners constitute an absolute requirement in the preoperative investigation of the Papillary Thyroid Carcinoma since according to our policy, identification of mutlifocality calls for a total thyroidectomy. 2. In our study, the correlation of the number of the foci was found to be significant:• with older age (it proved to be significant only at the level of 10% (p value = 0.097 \ 0.10) • male gender (p = 0.014) and • presence of N1a/N1b disease (p = 0.019) Foci number was not correlated with the gland weight and advanced local disease T3/4 status (p = 0.111). Interestingly enough, the number of foci was found to be higher in the tall cell variant, a feature that to the best of our knowledge has never been presented [1]. We can hypothesize, though, that the fact may be attributed to the much worse N status of these tumors in our series, which may indirectly be associated with the number of foci.3. We have no data on the accurate rate of mutlifocality before this study in our series. Admittedly, though, the percentage of the patients that harbored multifocal disease was high enough to warrant a study on the subject. 4. Even though we do follow up our patients, postoperative management is left on a team of dedicated endocrinologists/nuclear radiologists. To that end, we have limited data on the postoperative TG levels since our role kicks in again, whenever we are called for. Our study did not include relative postoperative data, but we reassure that the radioiodine doses do not differ between these patient groups. 5. Furthermore, we did not perform/include any genetic/mutational studies that may offer invaluable information on the subject of mutlifocality versus multicentricity. Nevertheless, these suggestions do serve as distinct guides for future refinement of our study, and from this point of view, we do feel honored for evoking such comments for our study on the subject of Multifocal Thyroid Papillary Carcinoma.

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confidence: 39%

Multifocal Versus Solitary Papillary Thyroid Carcinoma: Reply

Kiriakopoulos

Linos

2016

World j. surg.

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“…11,12 Disseminated metastases from follicular carcinoma at the time of diagnosis in a young patient Thyroid carcinoma is the second most common malignancy diagnosed during pregnancy 13 with breast cancer representing the first. Several studies have looked at the role of various reproductive and hormonal factors in the development and progression of thyroid carcinoma, yielding mixed results.…”

Section: Discussionmentioning

confidence: 99%

Follicular carcinoma of the thyroid with aggressive metastatic behavior in a pregnant woman: Report of a case and review of the literature

Parlea

Fahim²,

Muñoz³

et al. 2006

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Distant metastases as initial presentation of follicular carcinoma of the thyroid is rare, especially in young patients. We report the clinical and pathological features of a 33-year old pregnant patient with follicular carcinoma of the thyroid who presented with widespread bone and lung metastases at the time of diagnosis. the resected tumor had a focal insular component that showed extensive vascular invasion spreading beyond the thyroid capsule, and was associated with widespread bone and lung metastases. Despite its aggressive behavior, the tumor had low mitotic activity and Ki-67 nuclear labeling index. tumor cells showed high microvascular density and down-regulation of E-cadherin, a calcium-dependent trans-membrane epithelial protein molecule known to promote intercellular adhesion. We suggest that architectural differentiation of the tumor and cell proliferation rate are not reliable markers of metastatic behavior in this particular thyroid neoplasm. Microvascular density and down-regulation of E-cadherin expression in the tumor should be included among histologic hallmarks of metastatic potential. the role of pregnancy in the aggressive behavior of this tumor is discussed along with a literature review.

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“…Thyroid gland swellings may involve one lobe or have bilateral involvement. Thyroid gland swellings usually result from benign process, from malignant changes, or a process of unknown origin [12].…”

Section: Introductionmentioning

confidence: 99%

Surgical management of thyroid gland swellings in 22 May Hospital, Aden, Yemen

Bin-Gadeem

2021

Univ. Aden J. Nat. and Appl. Sc.

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Thyroid gland swellings are common clinical presentation of thyroid disorders of various etiologies, to which thyroidectomy is often carried out. The study aimed at analyzing demographic, clinical and pathologic features of patients with thyroid gland swellings, presented to 22 May Hospital and operated during the study period.as well as studying the types of operation used and their complications. This is a retrospective study. All patients who presented to 22 May Hospital from 1st March 2018 to 28th February 2020 and operated were included in the study. Patients with cervical lymphadenopathy, retrosternal goiter, and extrathyroidal tumor invasion were excluded from the study. Relevant data were collected and processed. For statistical analysis, SPSS software vs.17 was used. The Freeman and Halton extension of Fischer exact test was completed using Vassarstat. P-value of ≤0.05 was considered statistically significant. The study included 117 patients. Female preponderance was noted (91.5%). The average age group was 39.4 yrs, with SD ±13.8. Patients had an average duration of complain 50.3 months with SD ± 67.8. Most patients were euthyroid (88.1%) and had no previous thyroid operation (94%). The overall cancer detection rate on histopathology exam was 12% and papillary thyroid cancer was the most frequent histopathologiccancer type (92.8%). Statistically significant difference was found in the cancer detection rate in the different forms of thyroid swellings, the highest rate was found in solitary thyroid nodule (33.3%). Incidental thyroid cancer was found in 2.5% of the research population, but the histopathologic examination of their completed thyroidectomy specimen showed no cancer remnant. The total thyroidectomy was the most frequently practiced thyroidectomy procedure (45.8% of operations). No statistically significant difference was found in the major complications of thyroidectomy procedures of different resection extent. It could be concluded from this study that cancer detection rate in solitary thyroid nodule is significant, therefore, it needs to be carefully identified and investigated thoroughly.

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Thyroid Pathology

Cited by 3 publications

References 338 publications

Multifocal Versus Solitary Papillary Thyroid Carcinoma: Reply

Multifocal Versus Solitary Papillary Thyroid Carcinoma: Reply

Follicular carcinoma of the thyroid with aggressive metastatic behavior in a pregnant woman: Report of a case and review of the literature

Surgical management of thyroid gland swellings in 22 May Hospital, Aden, Yemen

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