Thyroid Profile and Factors Associated with Hypothyroidism Among Multidrug-Resistant Tuberculosis Patients Attending Saint Peter’s Specialized Hospital Addis Ababa, Ethiopia

Abstract

Background:The emergence of MDR-TB is a global public health problem. Hypothyroidism is one of the severe adverse drug reactions (ADRs) in MDR-TB patients on treatment. Representative data on hypothyroidism and its associated factors among MDR-TB patients are lacking. Objective: To determine thyroid profiles and associated risk factors among multidrugresistant TB patients during therapy with anti-MDR-TB regimen in Saint Peter Specialized Hospital Addis Ababa, Ethiopia from January to November 2020. Methods: A cross-sectional study was conducted in MDR-TB patients in Addis Ababa, Ethiopia. A total of 162 patients, who were older than 18 years, had bacteriologically confirmed MDR-TB and on treatment for more than one month were enrolled consecutively from the TB registration book. However, critically sick patients and those who were receiving additional drugs known to cause severe ADRs were excluded. Simple descriptive statistics were used to present the socio-demographic and clinical characteristics of the patients. A logistic regression model was used to assess the association between independent and dependent variables. A p-value <0.05 was considered as statistically significant in all analyses. Results: Mean age of the study participant was 35.9 ± 13.6 years. The prevalence of hypothyroidism was 32 (19.8%). The presence of co-morbidity, being underweight, and prothionamide use were significantly associated with hypothyroidism in MDR-TB patients on treatment. Conclusion: Hypothyroidism occurs commonly among MDR-TB patients. Presence of comorbidity, being underweight, and prothionamide drug use are the factors associated with hypothyroidism. Monitoring of thyroid function test during MDR-TB treatment and factors associated with hypothyroidism require attention to prevent complication.

Association between Sputum Culture Conversion and Body Mass Index among Multidrug- Resistant Tuberculosis Patients in Punjab, Pakistan: A multicenter retrospective study

“…The association between BMI and treatment outcomes in MDR-TB has been a subject of interest in the literature, with con icting results reported in various studies. (43)(44)(45) The results underscore the necessity for thorough assessments that encompass various factors like comorbidities, smoking habits, socioeconomic status, and adherence to treatment. These comprehensive evaluations are crucial for better comprehension of the intricate treatment outcomes in MDR-TB patients.…”

Hypothyroidism induced by antituberculosis drugs

“…Concomitent s-a constatat, că 17,3% dintre pacienții cu TB-MDR au avut hipotiroidism subclinic și 2,5%hipotiroidism manifest. Mai multe studii au raportat o proporție de hipotiroidism subclinic de la 7,8 la 40%, iar hipotiroidism manifest de la 2,4% la 38% [2].…”

“…Dezvoltarea tuberculozei multirezistente (TB-MDR) și a tuberculozei cu rezistență extinsă (TB-XDR) la medicamente devine o problem de sănătate publică globală datorită naturii contagioase a bolii, dificultăților de diagnostic și tratament. Rezistentă Mycobacterium tuberculosis la izoniazidă și rifampicină a constituit în 2019 circa 3,3% din cazurile noi și 18% din cele de TBC tratate anterior [2].…”

“…Monitorizarea TSH-ului la pacienții cu TB-MDR este esențială pentru gestionarea efectelor secundare ale medicamentelor antituberculoase utilizate înTB-MDR. [2].…”

“…Incidența hipotiroidismului în rândul pacienților cu TB-MDR sub tratament, ar putea varia din cauza diferitor factori, precum starea de nutriție a populației. Astfel, un studiu specific dintr-o anumită zonă geografică ar putea explica factorii de risc asociați cu incidența hipotiroidismului la pacienţii cu TB-MDR [1,2].…”