Thyroid profile and LDH Isoenzymes as prognostic biomarkers for diabetic and/or obese subjects

Johari, Turki Y; Ghoneim, Magdy A.; Moselhy, Said S

doi:10.4314/ahs.v18i3.28

Cited by 16 publications

(14 citation statements)

References 20 publications

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“…HDL was significantly lowest in DM-OB group, followed by NDM-OB group, followed by DM-NOB group and highest in NDM-NOB group. These results are in full agreement with the study of Johari et al [17] which has similar design to our study and found corresponding results.…”

Section: Discussionsupporting

confidence: 94%

Study of interleukin-18 ( IL18 ) and high sensitive C - reactive protein ( CRP ) in type 2 diabetes ( T2D ) with or without obesity

Kamel*

El-Baz

Emam

et al. 2020

Arab Journal of Nuclear Sciences and Applications

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Both diabetes and obesity are associated with chronic low-grade inflammation. IL-18 is a cytokine that stimulates various cell types and has pleiotropic functions. It is elevated in obesity, metabolic syndrome and type 2 diabetes (T2D).The hypothesis that serum level of IL-18 and high sensitive C-reactive protein can be used as markers for presence of chronic low-grade inflammation in type 2 diabetes more than in obesity per se was tested. The study recruited 80 subjects. They comprised 20 diabetic obese cases (DM-OB group), 20 diabetic non-obese cases (DM-NOB group), : 20 non-diabetic obese cases (NDM-OB group) and 20 non-diabetic non-obese subjects (NDM-NOB group). All participants were submitted to careful history taking, through clinical investigations and laboratory assessment. It was found that hs-CRP was significantly high in DMOB group (3.4±0.5 mg/dl) followed by NDM-OB group (2.9±0.4 mg/dl) then DM-NOB group (2.3±0.3 mg/dl) and least in NDM-NOB (0.8±0.3 mg/dl). It was also found that serum IL-18 was significantly highest in DMOB group (397.8±33.9 pg/mL) followed by NDM-OB (368.8±26.7 pg/mL) group followed by DM-NOB group (335.9±18.4 pg/mL) and least in NDM-NOB group (281.1±22.9 pg/mL). Serum IL-18 levels are directly correlated with BMI, waist circumference, hip circumference and waist/hip ratio in all the studied groups and with HbA1c in the diabetic groups. It could be concluded that Serum IL-18 and hs-CRP are related to diabetes and obesity. They are associated with dyslipidemia, poor glycemic control, insulin resistance and impaired liver and renal functions

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Section: Discussionsupporting

confidence: 94%

Study of interleukin-18 ( IL18 ) and high sensitive C - reactive protein ( CRP ) in type 2 diabetes ( T2D ) with or without obesity

Kamel*

El-Baz

Emam

et al. 2020

Arab Journal of Nuclear Sciences and Applications

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show abstract

“…There are some supporting results in the literature showing that HFD did not increase total cholesterol in all rat studies [36]. Furthermore, it is known that some obese patients have healthy lipid profile [37][38][39]. Thus, obesity likely leads to dyslipidemia, but not necessarily in all obese subjects.…”

Section: Discussionmentioning

confidence: 59%

Glomerular Collagen Deposition and Lipocalin-2 Expression Are Early Signs of Renal Injury in Prediabetic Obese Rats

Bukosza¹,

Kaucsár²,

Godó³

et al. 2020

Preprint

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Rats fed a high-fat diet with a single streptozotocin (STZ) injection developed obesity, prediabetes, cardiac hypertrophy and diastolic dysfunction. Here we aimed to explore the renal consequences of prediabetes in the same groups of rats. Male Long-Evans rats were fed normal chow (CON; n = 9) or high-fat diet containing 40% lard and were administered STZ at 20 mg/kg (i.p.) at week four (prediabetic rats, PRED, n = 9). At week 21 cardiac functions were examined (Koncsos et al., 2016) and blood and urine samples were taken. Kidney samples were collected for histology, immunohistochemistry and for analysis of gene expression. High-fat diet and streptozotocin increased body weight gain and visceral adiposity, and plasma leptin, elevated fasting blood glucose levels, impaired glucose and insulin tolerance, despite hyperleptinemia, plasma C-reactive protein concentration decreased in PRED rats. Immunohistochemistry revealed elevated collagen IV protein expression in the glomeruli, and Lcn2 mRNA expression increased, while Il-1β mRNA expression decreased in both the renal cortex and medulla in PRED vs. CON rats. Kidney histology, urinary protein excretion, plasma creatinine, glomerular Feret diameter, desmin protein expression and cortical and medullary mRNA expression of TGF-β1, Nrf2, PPARγ were similar in CON and PRED rats. Reduced AMPKα phosphorylation of the autophagy regulator Akt was the first sign of liver damage, while serum lipid and liver enzyme levels were similar. In conclusion, glomerular collagen deposition and increased lipocalin-2 expression were the early signs of kidney injury, while most biomarkers of inflammation, oxidative stress and fibrosis were negative in the kidneys of obese, prediabetic rats with mild heart and liver injury.

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“…There are some supporting results in the literature showing that HFD did not increase total cholesterol in all rat studies [36]. Furthermore, it is known that some obese patients have healthy lipid profile [37,38,39]. Thus, obesity likely leads to dyslipidemia, but not necessarily in all obese subjects.…”

Section: Discussionmentioning

confidence: 68%

Glomerular Collagen Deposition and Lipocalin-2 Expression Are Early Signs of Renal Injury in Prediabetic Obese Rats

Bukosza

Kaucsár

Godó

et al. 2019

IJMS

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Feeding rats with high-fat diet (HFD) with a single streptozotocin (STZ) injection induced obesity, slightly elevated fasting blood glucose and impaired glucose and insulin tolerance, and caused cardiac hypertrophy and mild diastolic dysfunction as published before by Koncsos et al. in 2016. Here we aimed to explore the renal consequences in the same groups of rats. Male Long-Evans rats were fed normal chow (CON; n = 9) or HFD containing 40% lard and were administered STZ at 20 mg/kg (i.p.) at week four (prediabetic rats, PRED, n = 9). At week 21 blood and urine samples were taken and kidney and liver samples were collected for histology, immunohistochemistry and for analysis of gene expression. HFD and STZ increased body weight and visceral adiposity and plasma leptin concentration. Despite hyperleptinemia, plasma C-reactive protein concentration decreased in PRED rats. Immunohistochemistry revealed elevated collagen IV protein expression in the glomeruli, and Lcn2 mRNA expression increased, while Il-1β mRNA expression decreased in both the renal cortex and medulla in PRED vs. CON rats. Kidney histology, urinary protein excretion, plasma creatinine, glomerular Feret diameter, desmin protein expression, and cortical and medullary mRNA expression of TGF-β1, Nrf2, and PPARγ were similar in CON and PRED rats. Reduced AMPKα phosphorylation of the autophagy regulator Akt was the first sign of liver damage, while plasma lipid and liver enzyme concentrations were similar. In conclusion, glomerular collagen deposition and increased lipocalin-2 expression were the early signs of kidney injury, while most biomarkers of inflammation, oxidative stress and fibrosis were negative in the kidneys of obese, prediabetic rats with mild heart and liver injury.

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Thyroid profile and LDH Isoenzymes as prognostic biomarkers for diabetic and/or obese subjects

Cited by 16 publications

References 20 publications

Study of interleukin-18 ( IL18 ) and high sensitive C - reactive protein ( CRP ) in type 2 diabetes ( T2D ) with or without obesity

Study of interleukin-18 ( IL18 ) and high sensitive C - reactive protein ( CRP ) in type 2 diabetes ( T2D ) with or without obesity

Glomerular Collagen Deposition and Lipocalin-2 Expression Are Early Signs of Renal Injury in Prediabetic Obese Rats

Glomerular Collagen Deposition and Lipocalin-2 Expression Are Early Signs of Renal Injury in Prediabetic Obese Rats

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