Thyroid Status and Nephron Loss - A study in Patients with Chronic Renal Failure, End Stage Renal Disease and/or on Hemodialysis

Giordano, Cinzia; Ng, De Santo; Carella, Carlo; Capodicasa, G; Amato, Giovanni; Nuzzi, F; Mioli,; Bazzato, G; Simone, De; Tarchini, A

doi:10.1177/039139888400700303

Cited by 8 publications

(3 citation statements)

References 8 publications

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“…Low T3 had been reported by Ramirez et al, Hegedus et al, Beckett et al, Singh et al, Iglesias et al and many others. [3][4][5][6][7] Ramirez and Spector et al study showed linear correlation between mean serum T3 and T4 and severity of renal failure which was similar to this study. 3,8 The TSH values in our study ranged from 0.01-30.13 micro IU/ml, the mean value being 4.69.…”

Section: Discussionsupporting

confidence: 87%

“…Kayima, et a1 and Giordano, et al have showed 90 studies regarding effect of dialysis on CKD patients with thyroid dysfunction. 5,14 These studies showed no significant improvement in thyroid profile after repeated haemodialysis. But in the patients who had undergone renal transplant surgery, most of the thyroid function parameters returned to normal with TSH below normal.…”

Section: Discussionmentioning

confidence: 90%

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Occurrence of subclinical and overt hypothyroidism among chronic kidney disease patients

et al. 2020

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Background: Chronic kidney disease (CKD) is one of the vital health problems worldwide leading to increased global morbidity and mortality. Thyroid dysfunction including hypothyroidism, hyperthyroidism and non-thyroidal illness has been reported in CKD patients. This study was conducted to determine the prevalence of subclinical and overt hypothyroidism among chronic kidney disease patients. This study also tried to correlate thyroid function abnormalities with severity of renal failure.Method: In this observational and cross sectional study, 100 patients of CKD who were admitted in Department of Medicine, Rajendra institute of medical sciences, Ranchi were studied for thyroid function abnormalities. Result: This study found that glomerular filtration rate (GFR) is positively correlated with serum T3 and T4 level (i.e. with decreasing renal function both T3 and T4 levels decreased). Serum creatinine levels were negatively correlated with serum T3 and T4 level.Conclusions: From this study it was established that CKD is associated with thyroid dysfunction characterized by low serum fT3 and fT4 with high TSH in some cases.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 90%

Occurrence of subclinical and overt hypothyroidism among chronic kidney disease patients

et al. 2020

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“…while T 4 is less affected; 46,47 however, some patients with end-stage renal disease are also diagnosed with hypothyroidism. 48 It has also been reported that other metabolic routes may be enhanced, resulting in higher T 3 sulphate concentrations.…”

Section: Renally Impaired Patientsmentioning

confidence: 99%

A Review of the Pharmacokinetics of Levothyroxine for the Treatment of Hypothyroidism

Colucci¹,

Yue²,

Ducharme³

et al. 2010

European Endocrinology

133

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Thyroxine hormone has been recognised since the early part of the nineteenth century and levothyroxine has been available since the mid-nineteenth century as a replacement for deficient thyroid hormones. While levothyroxine remains the staple treatment for hypothyroidism even to this day, its optimal use can be challenging. As is often the case with older drugs, the pharmacokinetics of levothyroxine is often under-appreciated or misunderstood and many factors influence the optimal dosing of levothyroxine. This article will review the pharmacokinetics of levothyroxine in the treatment of hypothyroidism and highlight major concepts that should aid both clinicians and researchers.

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Thyroid Function in Children on CAPD

Santo¹,

Carella²,

Fine³

et al. 1985

CAPD in Children

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Thyroid Status and Nephron Loss - A study in Patients with Chronic Renal Failure, End Stage Renal Disease and/or on Hemodialysis

Cited by 8 publications

References 8 publications

Occurrence of subclinical and overt hypothyroidism among chronic kidney disease patients

Occurrence of subclinical and overt hypothyroidism among chronic kidney disease patients

A Review of the Pharmacokinetics of Levothyroxine for the Treatment of Hypothyroidism

Thyroid Function in Children on CAPD

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