Thyroid-Stimulating Hormone, Thyroglobulin, and Thyroid Hormones and Risk of Differentiated Thyroid Carcinoma: The EPIC Study

Rinaldi, Sabina; Plummer, Martyn; Biessy, Carine; Tsilidis, Konstantinos K.; Østergaard, Jane Nautrup; Overvad, Kim; Tjønneland, Anne; Halkjær, Jytte; Boutron‐Ruault, Marie‐Christine; Clavel‐Chapelon, Françoise; Dossus, Laure; Kaaks, Rudolf; Lukanova, Annekatrin; Boeing, Heiner; Trichopoulou, Antonia; Λάγιου, Παγώνα; Trichopoulos, Dimitrios; Palli, Domenico; Agnoli, Claudia; Tumino, Rosario; Víneis, Paolo; Panico, Salvatore; Bueno-de-Mesquita, H. Bas; Peeters, Petra H.; Weiderpass, Elisabete; Lund, Eiliv; Quirós, J. Ramón; Agudo, Antonio; Molina, Esther; Larrañaga, Nerea; Navarro, Carmen; Ardanáz, Eva; Manjer, Jonas; Almquist, Martin; Sandström, Maria; Hennings, Joakim; Khaw, Kay‐Tee; Schmidt, Julie Kathrine; Travis, Ruth C.; Byrnes, Graham; Scalbert, Augustin; Romieu, Isabelle; Gunter, Marc J.; Riboli, Elio; Franceschi, Silvia

doi:10.1093/jnci/dju097

Cited by 101 publications

(109 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…10 The present study confirms that the simultaneously increased levels of both Tg and TSH are not useful in predicting thyroid malignancy in the preoperative period. By contrast, Tg levels were significantly lower in patients with DTC.…”

Section: Discussionsupporting

confidence: 68%

“…Some studies showed an increased risk of malignancy in a thyroid nodule with high serum TSH, 6,7,30,31 whereas others reported no relationship. 10,[33][34][35] In a meta-analysis including over 5000 cancer preoperatively, an increased level of serum Tg or TSH appear w not to be useful to predict malignant thyroid disorders. However, TSH:Tg ratio was found to be significantly increased in patients with thyroid cancer but it was not shown to be an independent predictor.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Which is the best predictor of thyroid cancer: thyrotropin, thyroglobulin or their ratio?

Yazici¹,

Mihmanlı²,

Bozkurt³

et al. 2016

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Which is the best predictor of thyroid cancer: thyrotropin, thyroglobulin or their ratio?

Yazici¹,

Mihmanlı²,

Bozkurt³

et al. 2016

View full text Add to dashboard Cite

“…Although hypothyroidism and hyperthyroidism have been hypothesised to be associated with thyroid cancer risk, the evidence has been somewhat inconsistent 28 29. Low thyroid stimulating hormone levels are thought to be associated with future thyroid cancer risk;30 however, laboratory studies in rats found that malathion was associated with increased thyroid stimulating hormone secretion 31. In agricultural areas, nitrate exposure via diet and drinking water has been associated with thyroid cancer and hypothyroidism;32 we were not able to control for nitrate intake in our analyses.…”

Section: Discussionmentioning

confidence: 88%

Organophosphate insecticide use and cancer incidence among spouses of pesticide applicators in the Agricultural Health Study

et al. 2015

View full text Add to dashboard Cite

Objectives Organophosphates (OP) are among the most commonly used insecticides. OPs have been linked to cancer risk in some epidemiologic studies, which have been largely conducted in predominantly male populations. We evaluated personal use of specific OPs and cancer incidence among female spouses of pesticide applicators in the prospective Agricultural Health Study cohort. Methods At enrollment (1993–1997) spouses provided information about ever use of specific pesticides, including ten OPs, demographic information, reproductive health history, and other potential confounders. We used Poisson regression to estimate relative risks (RRs) and 95% confidence intervals (95% CIs) for all cancers diagnosed through 2010 for North Carolina and 2011 for Iowa. Results Among 30,003 women, 25.9% reported OP use, and 718 OP-exposed women were diagnosed with cancer during the follow-up period. Any OP use was associated with an elevated risk of breast cancer (RR = 1.20, 95% CI: 1.01, 1.43). Malathion, the most commonly reported OP, was associated with increased risk of thyroid cancer (RR = 2.04, 95% CI: 1.14, 3.63) and decreased risk of non-Hodgkin lymphoma (RR = 0.64, 95% CI: 0.41, 0.99). Diazinon use was associated with ovarian cancer (RR = 1.87, 95% CI: 1.02, 3.43). Conclusions We observed increased risk with OP use for several hormonally-related cancers, including breast, thyroid, and ovary, suggesting potential for hormonally-mediated effects. This study represents the first comprehensive analysis of OP use and cancer risk among women, and thus a need for further evaluation.

show abstract

“…Some studies have found that alcohol intake have an effect on thyroid volume, thyroid function and the responsiveness of hypothalamic-pituitary-thyroid axis [60–62], which subsequently lead to the change of peripheral thyroid hormone concentrations. However, the influence is elusive with regarding to the peripheral thyroid hormone concentrations on thyroid cancer risk [63–65]. Third, alcohol could also potentially influence thyroid cancer risk by altering sex steroid hormone levels [66–68].…”

Section: Discussionmentioning

confidence: 99%

A meta-analysis of alcohol consumption and thyroid cancer risk

Wang

Cheng

et al. 2016

Oncotarget

View full text Add to dashboard Cite

BackgroundIt is still inconclusive whether alcohol consumption affects the risk of thyroid cancer. We conducted a meta-analysis of available epidemiological data to address this issue.ResultsCompared with nondrinkers, the pooled relative risks (RRs) and corresponding 95% confidential intervals (CIs) of thyroid cancer were 0.80 (95% CI 0.71-0.90) for any drinkers, 0.81 (95% CI 0.70-0.93) for light and 0.71 (95% CI 0.63-0.79) for moderate drinkers. The dose–response analysis suggested that there is no evidence of a dose-risk relationship between alcohol intaking and thyroid cancer risk (P = 0.112).MethodsEligible studies were identified by searching PubMed and EMbase databases. A total of 24 studies, included 9,990 cases with thyroid cancer, were included in this meta-analysis. We defined light alcohol intake as ≤ one drink/day and moderate as >one drink/day. The summary risk estimates were calculated by the random effects model. A dose-response analysis was also conducted for modeling the dose-risk relation.ConclusionThis meta-analysis confirmed an inverse association between alcohol consumption and thyroid cancer risk. Further studies are needed to better understand the potential mechanisms underlying this association.

show abstract

Thyroid-Stimulating Hormone, Thyroglobulin, and Thyroid Hormones and Risk of Differentiated Thyroid Carcinoma: The EPIC Study

Abstract: High Tg levels precede by up to 8 years the detection of TC, pointing to a long sojourn time of the disease. Low TSH levels may predispose to TC onset. Neither marker has sufficient accuracy to be a screening test.

Cited by 101 publications

References 29 publications

Which is the best predictor of thyroid cancer: thyrotropin, thyroglobulin or their ratio?

Which is the best predictor of thyroid cancer: thyrotropin, thyroglobulin or their ratio?

Organophosphate insecticide use and cancer incidence among spouses of pesticide applicators in the Agricultural Health Study

A meta-analysis of alcohol consumption and thyroid cancer risk

Contact Info

Product

Resources

About