Thyroid uptake of 67Ga-citrate is associated with thyroid autoimmunity and hypothyroidism in patients with sarcoidosis

Antonelli, Alessandro; Fazzi, P; Fallahi, Poupak; Ferrari, Silvia; Grosso, M; Boni, Giuseppe; Ferrannini, Ele; Mariani, Giuliano

doi:10.1007/s00259-008-0932-9

Cited by 6 publications

(5 citation statements)

References 31 publications

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“…20 Data derived from larger studies have not shown positive TRAbs in sarcoidosis. 12 However, our findings show a significantly higher frequency of TRAbs in sarcoidosis patients compared to gendermatched controls. Moreover, in our study the presence of TRAbs was almost unequivocally associated with ultrasonographic signs of thyroid autoimmunity (dyshomogeneous thyroid parenchyma).…”

Section: Discussioncontrasting

confidence: 53%

“…8 Controversy also exists regarding the presence of thyroid antibodies in sarcoidosis patients, with studies pointing to increased prevalence of antithyroid peroxidase antibodies (TPOAbs) and antithyroglobulin antibodies (TGAbs) 10 in sarcoidosis patients, while others have failed to document any differences. 11 Data concerning TSH receptor antibodies (TRAbs) are rather scarce, most of them derived from case reports; meanwhile, in a prospective study by Antonelli et al 12 the authors failed to demonstrate increased TRAbs titles in sarcoidosis. Thus, currently no definite conclusions can be drawn regarding the association of sarcoidosis with thyroid disorders.…”

Section: Introductionmentioning

confidence: 99%

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Increased primary autoimmune thyroid diseases and thyroid antibodies in sarcoidosis: evidence for an under-recognised extrathoracic involvement in sarcoidosis?

Malli¹,

Bargiota²,

Theodoridou³

et al. 2012

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OBJEcTIVE AND DEsIGN: sarcoidosis has been associated with thyroid diseases. However, until today no definite conclusions have been drawn. We aimed to assess the frequency of thyroid disorders and the levels of thyroid hormones and thyroid antibodies in 68 sarcoidosis patients and 75 controls. Additionally, we performed ultrasonography and fine-needle aspiration. rEsULTs: In this prospective case control study conducted in the University Hospital of Larissa, Greece, overt thyroid disease was present in 29.4% of patients and 16.1% of patients presented clinical autoimmune thyroid disease. sarcoidosis patients had a significantly higher frequency of serological autoimmunity. Female patients had significantly increased frequency of positive TsH receptor antibodies (TrAbs) and antithyroid peroxidase antibodies (TPOAbs) when compared to gender-matched controls (40% vs 0%, p<0.001, and 28.8% vs 11.86%, p=0.029, respectively). The hypoechoic pattern of the thyroid was more frequent in female patients vs controls (p<0.001). Male patients had a higher frequency of TrAbs and hypoechoic pattern of the thyroid gland (43.4% vs 0%, p=0.002, and 39.1% vs 6.25%, p=0.021, respectively). Indices of thyroid autoimmune disease were significantly more frequent in sarcoidosis patients vs gender-matched controls. Increased TPOAbs were significantly associated with clinical autoimmune disease in sarcoidosis. cONcLUsIONs: Overall, the findings derived from this study suggest that thyroid disorders are frequent in sarcoidosis. This association may potentially be the result of increased thyroid antibodies.

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Section: Discussioncontrasting

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Increased primary autoimmune thyroid diseases and thyroid antibodies in sarcoidosis: evidence for an under-recognised extrathoracic involvement in sarcoidosis?

Malli¹,

Bargiota²,

Theodoridou³

et al. 2012

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“…In addition, she had elevated thyroid peroxidase antibodies which is also well documented in various studies. [ 9 10 ] While the hypothyroid and euthyroid state in Hashimoto's thyroiditis is well known and such a diagnosis has therapeutic and prognostic implications; complete thyroid function tests done were, however, normal. The patient was explained regarding her basic disease predispositions and advised close follow-up for the recurrence of primary disease and development of other autoimmune manifestations.…”

Section: Discussionmentioning

confidence: 99%

A rare case of eyelid sarcoidosis presenting as an orbital mass

Gaspar

Gupta

Singh

2016

Indian J Ophthalmol

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Intraorbital sarcoidosis presenting externally as a solitary eyelid mass has been described in the literature as isolated case reports. We describe a rare case of asymptomatic sarcoidosis with orbital mass as the presenting feature in a young woman. The lesion was excised with the clinical possibility of a thrombosed varix. On histology, the lesion was characterized by numerous nonnecrotizing epithelioid cell granulomas with several multinucleated giant cells containing abundant asteroid bodies and oxalate crystals. No tubercular bacilli were detected. A diagnosis of sarcoidosis was rendered and on further clinical work-up, she was detected to have hilar lymphadenopathy. Sarcoidosis should be considered in the differential diagnosis of orbital mass as it could be the initial manifestation of the disease process.

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“…To assess the association of Ga-67 citrate thyroid uptake with thyroid disorders in S patients, 84 subjects were evaluated by ultrasonography, serum thyroid hormones and antithyroid antibodies, and FNA ( 11 ).…”

Section: Thyroid Autoimmunity and Sarcoidosismentioning

confidence: 99%

“…Sarcoidosis is associated with autoimmunity such as autoimmune thyroid disorders (AITDs) ( 10 , 11 ).…”

Section: Introductionmentioning

confidence: 99%

Sarcoidosis and Thyroid Autoimmunity

2017

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Most of the studies have shown a higher risk for subclinical and clinical hypothyroidism, antithyroid autoantibodies [overall antithyroid peroxidase antibodies (TPOAb)], and in general, thyroid autoimmunity, overall in the female gender in patients with sarcoidosis (S). A significantly higher prevalence of clinical hypothyroidism and Graves’ disease was also described in female S patients with respect to controls. Gallium-67 (Ga-67) scyntigraphy in S patients, in the case of thyroid uptake, suggests the presence of aggressive autoimmune thyroiditis and hypothyroidism. For this reason, ultrasonography and thyroid function should be done in the case of Ga-67 thyroid uptake. In conclusion, thyroid function, TPOAb measurement, and ultrasonography should be done to assess the clinical profile in female S patients, and the ones at high risk (female individuals, with TPOAb positivity, and hypoechoic and small thyroid) should have periodically thyroid function evaluations and suitable treatments.

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Thyroid uptake of 67Ga-citrate is associated with thyroid autoimmunity and hypothyroidism in patients with sarcoidosis

Abstract: (67)Ga thyroid uptake is associated with the presence of aggressive autoimmune thyroiditis and hypothyroidism in S patients; thyroid function and ultrasonography should be performed in the presence of (67)Ga thyroid uptake.

Cited by 6 publications

References 31 publications

Increased primary autoimmune thyroid diseases and thyroid antibodies in sarcoidosis: evidence for an under-recognised extrathoracic involvement in sarcoidosis?

Increased primary autoimmune thyroid diseases and thyroid antibodies in sarcoidosis: evidence for an under-recognised extrathoracic involvement in sarcoidosis?

A rare case of eyelid sarcoidosis presenting as an orbital mass

Sarcoidosis and Thyroid Autoimmunity

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